|Year : 1958 | Volume
| Issue : 3 | Page : 55-60
Action of largactil on glaucoma
Yamunabai Nair Hospital, Bombay, India
|Date of Web Publication||8-May-2008|
A M Gokhale
Yamunabai Nair Hospital, Bombay
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Gokhale A M. Action of largactil on glaucoma. Indian J Ophthalmol 1958;6:55-60
The study of action of Largactil in reducing the intraocular tension in Glaucoma began quite accidentally.
A case of retinal detachment which was for operation was given preoperatively Lagactil as a sedative and antiemetic. Shortly after starting the operation it was found that the pupil (which was previously dilated) had contracted, and led thus to difficulty in observing the fundus.
This accidental finding of action of Largactil in contracting the pupil as well as its established sedative effect led me to try its action on glaucoma patients for reducing the tension.
Attached herewith is the preliminary report of about 30 cases on whom Largactil was tried and the figures show the diminution in mm. of mercury of the intraocular tension.
I was assisted by Dr. H. -K. Dordi for recording the tension.
Further investigation on the use of Largactil on raised intraocular tension is being continued.
| Conclusions|| |
In 20 cases (22 eyes) of primary congestive glaucoma, Largactil was found effective in bringing about a significant reduction of tension, whereas in 12 cases (14 eyes) of secondary glaucoma, the drop was not significant. Since Largactil was tried in only one case of chronic simple glaucoma (Case No. II) the drop cannot be considered conclusive
There was no conclusive difference in the mode of administration of the drug and the dosage, the drug not having acted uniformly in different subjects.
It may be preferred over Diamox in being much cheaper, sedative, antiemetic and analgesic.
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