|Year : 1962 | Volume
| Issue : 3 | Page : 73-75
A case of carcinoma of both upper lids
KN Mathur, Usha Kehar, PN Wahi, TP Agarwal
Departments of Ophthalmology and Pathology, S. N. Medical College, Agra, India
|Date of Web Publication||18-Mar-2008|
K N Mathur
Departments of Ophthalmology and Pathology, S. N. Medical College, Agra
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Mathur K N, Kehar U, Wahi P N, Agarwal T P. A case of carcinoma of both upper lids. Indian J Ophthalmol 1962;10:73-5
|How to cite this URL:|
Mathur K N, Kehar U, Wahi P N, Agarwal T P. A case of carcinoma of both upper lids. Indian J Ophthalmol [serial online] 1962 [cited 2020 Aug 8];10:73-5. Available from: http://www.ijo.in/text.asp?1962/10/3/73/39564
Carcinoma of the lids as a single independent tumour is commonly seen constituting about 42% (Duke-Elder) of all the malignant growths of the eye. Histologically basalcell carcinoma is the commonest, next being the squamous-cell carcinoma, the baso-squamous being the least common (Birge). Rarely multiple independent carcinomatous tumours may be present in both the eyes of the same patient (Cochram and Robinson). It is extremely rare, to have multiple independent tumours of different histological nature in one individual. A case showing two different histological patterns of tumours in two lids is therefore reported.
| Case Report|| |
Patient named B. A., aged 30 years, Hindu female was admitted in this hospital on 3rd April, 1960 with the complaints of gradually increasing swelling of both the upper lids, more so of the left eye and a notch in the right upper lid, for the last three months. During this period, she developed generalised weakness of the body and lost a good amount of weight. For the last one month she was having occasional bleeding from the under surface of the left upper lid and occasional purulent discharge from the ulcer on the skin surface of that lid.
She was a young villager of average build, fair, with normal pulse, temperature and blood pressure.
The right eye [Figure - 1] shows the presence of a notch in the right upper lid extending horizontally a little away from the punctum upto the junction of the middle and the outer third of the lid margin. The margins of the notch are pigmented, bluish in colour, raised above the surface level and non-tender. The swelling extends diffusely in the whole upper lid, restricting the active movements slightly. The remaining eye lashes are matted and mild conjunctival congestion is present. Rest of the eye is normal.
The left eye [Figure - 1],[Figure - 2] shows a prominent, diffuse swelling involving the whole thickness of the left upper lid measuring about 3.5 x 2.5 x 2.5 cms. and is triangular in shape with the base at orbital margin. Prominent veins can be seen on the skin surface. The skin is fixed with the growth. There is an ulcer present on the skin measuring about 1 x 1 cm. with irregular hard margins and the floor covered by slough. The palpebral surface is much hypertrophied, where bleeding points could be seen. Active movements of the lids were restricted because of the heavy weight of the growth, but passively, it was freely mobile. The cornea could be seen only after lifting the lid mechanically. Clinically there was no involvement of any of the lymph nodes.
Histological examination of the tumour in the right eye revealed solid masses of darkly staining cells extending into the dermis as seen in [Figure - 3]. All the cells are of the same type as the basal cells of the epidermis and the nuclei take up an intensely dark blue stain with haematoxylin. The cells at the periphery of these solid masses show a typical palisading arrangement. A high power study of this tumour showed few abnormal mitotic figures. There is no evidence of keratinization or formation of cell nests. The inter-cellular matrix consists of bundles of adult connective tissue sparsely infiltrated by mononuclear cells.
The tumour in the left eye consisted of groups and sheets of malignant epithelial cells growing down into the dermis as seen in [Figure - 4]. In the centre of these masses of malignant epithelial cells the process of keratinization can be recognized forming epithelial pearls. Most of the malignant cells are polygonal, while others are enlarged. Presence of inter-cellular keratin bridges can be recognized at a number of places. About 2 to 4 abnormal mitotic figures can be seen per high power of the field. The inter-cellular matrix consists of loose vascularised connective tissue containing focal and diffuse collection of lymphocytes.
Involvement of the orbit and metastases in the lungs was excluded by X-ray. Blood picture showed slight microcytic hypochromic anaemia.
| Comment|| |
The percentage of carcinoma of the eye lids in all its different cutaneous forms (Basal-cell, Squamous-cell and Baso-squamous-cell) is commonly seen as single independent tumour constituting about 42% of all the neoplasms of the eye and about 12% of all facial cancers. It is rare to find multiple independent tumours Cochrum and Robinson found a squamous-cell epithelioma on the right lower lid. which was apparently adequately treated by radium. Twenty-six months later similar tumours appeared on left eye ball and right conjunctiva.
The commonest age for carcinoma lids is 60-70 years (Duke-Elder), 50-55 years (Reese). Before 40 years and after 80 years, it is rare though cases of younger and older age groups have been reported varying from 3½ years to 85 years. Males are more commonly affected than females 65 : 35 (males : females) The site, which is most frequently effected is near the margin of the lower lid towards the inner canthus. The percentage for the involvement of different sites of the eye as reported in the literature are lower lid 51-54 per cent; upper lid 10-13 per cent; internal canthus 28-32 per cent; and external canthus 5-7 per cent. Basal cell Carcinoma is more common than the Epidermoid Carcinoma.
| Summary|| |
A case of Carcinoma lids is being reported in a lady of thirty years of age with independent carcinomatous tumours of different histological nature in the two sides; the left upper lid having Epidermoid Carcinoma Grade II and the right upper lid having Basal-cell Carcinoma.
| References|| |
Cochrani and Robinson : (1922). A de derm. Sypb. iii : 385.
Duke-Elder, W. S. : (1962). Text book of Ophthalmology. V5. P. 5037 ,
Henry Kimpton, London.
Reese, A. B.: (1951) . Tumours of the Eye. p. i Paul B, Hoeber. Inc.
[Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4]