|Year : 1969 | Volume
| Issue : 1 | Page : 31-32
Dianabol in corneal ulcers
VN Prasad, HC Gupta, CN Shukla
Department of Ophthalmology, Ganesh Shanker, Vidyarthi Memorial Medical College, Kanpur, India
|Date of Web Publication||4-Jan-2008|
V N Prasad
Department of Ophthalmology, Ganesh Shanker, Vidyarthi Memorial Medical College, Kanpur
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Prasad V N, Gupta H C, Shukla C N. Dianabol in corneal ulcers. Indian J Ophthalmol 1969;17:31-2
Some times the ulceration of cornea is a problem to ophthalmologists. A good number of old debilitated adults and Marasmic children develop complications of corneal ulcer, and the healing process is much delayed. A number of therapeutic agents have been used from time to time to promote healing and to lessen the density of the opacity, no work has been done so far on the role of anabolic agents in healing of these ulcers.
Methan dianone (Dianabol) is an oral anabolic agent which enhances protein synthesis. In response to such therapy the negative nitrogen balance becomes positive, thus helping in protein metabolism. Dianabol has been found to stimulate erythropoiesis when used with antianaemic drugs.
The positive value of Dianabol in healing of wounds of other parts of the body have been established, but its value in healing of corneal ulcers is yet to be established, as the cornea differs from other parts of the body by being avascular in nature.
| Material And Method|| |
One hundred and twenty five cases of corneal ulcers were studied using fifty cases as control. In the control group only the routine treatment of corneal ulcers was given; Penicillin drops, Achromycin and Atropine eye ointments, Multivitamin tablets, pad and bandage. In a series of 75 test cases, Dianabol, one tablet of 5 mg was given daily with milk in addition to the above routine treatment.
| Observations|| |
The average relief of symptoms and signs in days, the healing time of corneal ulcer in days and the type of opacity formed were duly noted.
The signs, symptoms and healing time are reduced in days and the resultant corneal opacity in also less in cases where dianabol was used.
| Discussion|| |
The above observations have clearly shown that by the use of dianabol there is early relief in symptoms, signs and healing time of corneal ulcer. Even the resultant opacity formation is also less.
It is commonly seen in healthy individuals that corneal ulcer heals rapidly while in cases of debilitated persons healing is much delayed. General treatment is never to be forgotten in dealing with more severe type of corneal ulcers, and every thing must be done to raise the patient's resistance.
It is now an established fact that a positive nitrogen balance is necessary for wound healing. In conditions where there is a negative nitrogen balance the process of wound healing is much delayed, which is commonly seen in debilitated persons and Marasmic children. Old persons of a poor country mostly suffering from negative nitrogen balance; in other words, their bodies do not produce and store proteins properly, leading to a feeling of declining physical energy.
In poorer countries where there is difficulty to have good diet, this negative nitrogen balance can be overcome by addition of anabolic hormones (Dianabol) to achieve positive nitrogen balance, thus accelerating healing of ulcers.
ARBORELIUS (1963) has used this anabolic hormone (Dianabol) in healing of resistant leg ulcer with promising results. Uptil now, the use of anabolic agents in corneal ulcer has not been carried out but it has given very encouraging results in this series.
| Summary|| |
Dianabol an anabolic agent was given by mouth with encouraging results in promoting the healing of corneal ulcers, especially in debilitated subjects.
We are thankful to Ciba Co. for generous supply of drug.
| References|| |
BISHT. D. B. (1963) Curr. Med. Practice 7, 528.
DUKE-ELDER (1938) Text book of Oph. Vol. II, p. 1925. Henry Kimpton.
DUKE-ELDER (1959) Parsons Diseases of the eye p-196 I. AND A CHURCHILL.
PRASAD, V. N. AND NARAIN, B. (1968) Antiseptic 65, 265.
ROY B. B. (1964) Curr. Med. Practice 8, 662.