|Year : 1979 | Volume
| Issue : 4 | Page : 49-50
Glucose 6-Phosphate dehydrogenase deficiency in congenital and senile cataracts
UC Behera, G Devdas
M.K.C.G. Medical College Berhampur, Orissa, India
U C Behera
Professor M.K.C.G. Medical College, Berhampur, Orissa
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Behera U C, Devdas G. Glucose 6-Phosphate dehydrogenase deficiency in congenital and senile cataracts. Indian J Ophthalmol 1979;27:49-50
|How to cite this URL:|
Behera U C, Devdas G. Glucose 6-Phosphate dehydrogenase deficiency in congenital and senile cataracts. Indian J Ophthalmol [serial online] 1979 [cited 2020 Apr 9];27:49-50. Available from: http://www.ijo.in/text.asp?1979/27/4/49/32573
Glucose-6-Phosphate dehydrogenase (G6PD) is recognised as an important enzyme in glucose metabolism and its deficiency is commonly associated with a number of hereditary disorders. It is estimated that at least 100 million of total population of different ethenic groups in the world suffer from this deficiency. The incidence varies from 2 to 20%. A recent survey in southern Orissa showed an incidence of 6.1%. There are some evidences to suggest that G6PD deficiency may be associated with cataractous changes in the lens. The present study aims at investigating association of erythrocytic G6PD deficiency with various types of cataracts.
| Materials and Methods|| |
It includes 25 cases, each of congenital cataract, senile immature cataract, senile mature cataract, normal lens, and 10 cases of traumatic cataract and 15 hypermature cataract.
| Observations|| |
The number of patients in each age group were fairly comparable. The incidence of G6PD deficiency was highest in 1-10 age group (63%) and the incidence declined with age. The sex difference was not significant (Male: 16.6%; Female: 20.7%).
In the persent study 3 out of 21 cases of congenital cataract with G6PD deficiency index had positive family history regarding incidence of congenital cataract occuring in other members of his family or near relations.
Twenty one of 25 cases of congenital cataract had G6PD deficiency. There seems to be a significant association. Of the 4 cases without erythrocytic G6PD deficiency one had gastro-intestinal disorder and another had serum V.D.R.L. positive. Of the 21 cases of congenital cataract with G6PD deficiency, 7 had associated disorders: coloboma iris-2 cases, Marfan's Syndrome-2 cases, microphthalmos-I case, skull deformities -1 case, hepatosplenomegaly-1 case.
History of medication prior to noticing cataract:
In the present study 4 out of 25 cases gave the history of taking medicines like salicylates, sulfaroxazole and chloroquin group of drugs prior to their noticing cataract All had erythrocytic G6PD deficiency.
| Conclusion|| |
In conclusion it can be stated that in the deficient state of G6PD, there seems to occur some important derangement of lens metabolism, probably accumulation of peroxides, resulting in cataract formation.