Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 2302
  • Home
  • Print this page
  • Email this page

   Table of Contents      
ARTICLES
Year : 1982  |  Volume : 30  |  Issue : 5  |  Page : 463-464

Evaluation of anti-inflammatory drugs after cataract surgery


R. N.T Medical College, Udaipur, India

Correspondence Address:
R L Agarwal
Medical College, Udaipur, Rajasthan
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

How to cite this article:
Agarwal R L, Lodha S K, Nagar C K, Bhasin S. Evaluation of anti-inflammatory drugs after cataract surgery. Indian J Ophthalmol 1982;30:463-4

How to cite this URL:
Agarwal R L, Lodha S K, Nagar C K, Bhasin S. Evaluation of anti-inflammatory drugs after cataract surgery. Indian J Ophthalmol [serial online] 1982 [cited 2020 May 27];30:463-4. Available from: http://www.ijo.in/text.asp?1982/30/5/463/29229

Inflammation following an operative trauma is a rule. Various drugs have been tried and used for the management of inflammatory reactions. In this study Ibuprofen; Oxyphen­butazone and Prednisolone were used to control the inflammatory reaction after cataract surgery. The error of judgement and prejudice in drawing the results was eliminated by mak­ing it a double blind study.


  Materials and methods Top


In all 100 cases were selected who had no other occular or systemic pathology and were divided in 4 groups, each of 25 cases group one of control and group 2,3 & 4 were admini­stered; Oxyphenbutazone 600 mg. Ibuprofen 600 mg and Prednisolone 20 mg daily in three divided doses respectively.

The drugs were given in identical prefilled and coded (A, B, C & D) capsules and same dose schedule was followed for all the cases.

An up to date record of each patient was maintained on separate case sheet. The results were evaluated statistically.


  Observations and discussion Top


The parameters assessed were as follows

a) Discharge :--Discharge was recorded only in prednisolone group while not in other groups.

b) Lid Swelling :-Lid swelling was least in oxyphenbutazone and Ibuprofen group. Pred­nisolone group had even more lid swelling than control group.

c) Chemosis :-These drugs have an impact in reducing the chemosis but definitely it was less in Ibuprofen and oxyphenutazone group then control and prednisolone group.

d) Ciliary Congestion :--The drugs reduced the number of cases of Ciliary congestion in comparison of control cases. It was much less in oxyphenbutazone and Ibuprofen group.

e) Keratitis :-The drugs reduced the cases of keratitis in comparison to control group, it was least in oxyphenbutazone and Ibuprofen group.

f) Hyphema was present in all the groups in lesser or greater extent but it was more in control group than drug groups.

The parameters noted on slit lamp exami­nation were as follows :-­

a) Keratitis :-The drug reduced the num­ber of cases of Keratitis in comparison to con­trol group. It was much less in Ibuprofen and oxyphenbutazone group.

b) Hyphema :-Hyphema was present equally in control and prednisolone group but it was absent in Ibuprofen and oxyphenbuta­zone group.

c) Pigment Dispersion :-Oxyphenbutazone had greater role in complete prevention of pigment dispersion post operatively in compari­sion to Ibuprofen and prednisolone group while it was present in much more number of cases in control group.

d) Aqueous Flare and K.P.s. :-The drugs had greater role in complete prevention of aqueous fl ir,- and K.P.s. while it was present in cases of control group.

If proper suturing is done, corticosteroids do not prevent wound healing, if given oraly for certain time.

Side effects with anti-inflammatory drugs can be reduced to zero, if patients are properly assessed for their contraindication and suppor­ted by antacids orally.

Patients on Ibuprofen and oxoyhenbuta­zone were hospitalised for less duration than control and prednisolone group, while it was least in oxyphenbutazone group.

To conclude the anti-inflammatory effect of oxyphenbutazone and Ibuprofen was better as compared to cases on prednisolone and control group. The over all assessment favours the superiority of Oxyphenbutazone over other drugs put under trial.




 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Materials and me...
Observations and...

 Article Access Statistics
    Viewed4187    
    Printed44    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal