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ARTICLES |
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Year : 1982 | Volume
: 30
| Issue : 6 | Page : 613-615 |
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Estimation of plasma fibrinogen content and fibrinolytic activity in cases of diabetes mellitus with" and without retionopaty
Anil K Kotharid, RL Agarwal
Udaipur, India
Correspondence Address: Anil K Kotharid Dr. Kothari's Eye Hospital 14, Town Hall Road, Udaipur India
Source of Support: None, Conflict of Interest: None | Check |
How to cite this article: Kotharid AK, Agarwal R L. Estimation of plasma fibrinogen content and fibrinolytic activity in cases of diabetes mellitus with" and without retionopaty. Indian J Ophthalmol 1982;30:613-5 |
This study has been undertaken to find out whether diabetes with and without retinopathy have changes in their coagulation & fibrinolytic system predisposing to bleeding or to vascular occlusion and ascertain any relationship between them so that this may be a guideline for the early diagnosis and management of the potential case of diabetes who might develop retinopathy at a later stage.
Materials and methods | | |
The study consisted of three groups of individuals. Each group had 20 individuals. In group A twenty healthy subjects were taken as control. Group B comprised of patients of diabetes mellitus retinopathy add group C included patients of diabetes mellitus with retinopathy. All patients were from the medical wards of Medical College Hospital, Udaipur. The criteria of diagnosis were a typical history, certain physical findings and chiefly presence of sugar in urine and high fasting blood sugar level. Fundus examination was done under full mydriasis.
Urine sugar examination, blood sugar (somogyii-Nelson method), plasma fibrinogen estimation euglobin englobinl ysistime were estimated each and statistical analysis of the results was compiled.
Observations and discussion | | |
It ranged, in control cases from 189.47 mg % to 383.68 mg % in group B from 268.42 mg % to 510.53 mg % and in group C from 321.05 mg % to 626.32 mg%.
This show that the plasma fibrinogen level was high in diabetics without retinopathy than control and still higher in diabetics with retinopathy.
It ranged in control cases from 60.50 units to 86.96 units, in group B from 40.82 units to 86.96 units and in group C from 31.25 units to 57.14 units.
Further more [Table - 3][Table - 4] shows that mean fibrinogen level was higher in cases of diabetes with retinopathy, who were having retinal haemorrhage than in cases who were not having retinal haemorrhages. Meen fibrinolytic activity was found to be low in cases.who were having haemorrhages.
The plasma fibrinogen level in withont retinopathy group and retinopathy group were significantly higher (P<0.001 ) than control. The values were also significantly higher (P<0.001 ) in retinopathy group than in without retinopathy group. (For 38 degrees of freedon, at 0.1% level of significance the value of `t' is 3.6 as found on reference to `t' table.
(`t' = 3.6, P < 0.001, significant at 0.1% level). In the same way mean fibrinolytic activity in without retinopathy group was significantly lower (P<0.001 ), than controls.
The mean fibrinolytic activity was also significantly lower ( P<0.001 ) in retinopathy group than without retinopathy group.
Our results supports along with others, the observations of Lars Olof Almer (1975), who studied 135 patients with and without retinopathy and found that mean fibrinolytic activity was 28.2 ± S. E. 2.8 mm 2 lysis (Fibrin plate method), compared with 34.4 + 3.3 in the controls).
This study show that retinopathy in diabetic patients is accompanied by quantitative changes of the components of the fibrinolyitc system, thereby giving an apportunity for early diagnosis and management of the case as microangiopathy is generalised and gives an idea of renal changes even in the absence of proteinuria. (dewardener 1967).
It is very likely that thromboemblic occlusion of the microvasculature might be caused by a disturbance of the delicate equilibrium between coagulation and fibrinolysis.
[Table - 1], [Table - 2], [Table - 3], [Table - 4]
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