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ARTICLES
Year : 1982  |  Volume : 30  |  Issue : 6  |  Page : 613-615

Estimation of plasma fibrinogen content and fibri要olytic activity in cases of diabetes mellitus with" and without retionopaty


Udaipur, India

Correspondence Address:
Anil K Kotharid
Dr. Kothari's Eye Hospital 14, Town Hall Road, Udaipur
India
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Source of Support: None, Conflict of Interest: None


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How to cite this article:
Kotharid AK, Agarwal R L. Estimation of plasma fibrinogen content and fibri要olytic activity in cases of diabetes mellitus with" and without retionopaty. Indian J Ophthalmol 1982;30:613-5

How to cite this URL:
Kotharid AK, Agarwal R L. Estimation of plasma fibrinogen content and fibri要olytic activity in cases of diabetes mellitus with" and without retionopaty. Indian J Ophthalmol [serial online] 1982 [cited 2019 Sep 16];30:613-5. Available from: http://www.ijo.in/text.asp?1982/30/6/613/29297

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Table 4

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Table 3

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Table 2

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Table 2

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Table 1

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Table 1

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This study has been undertaken to find out whether diabetes with and without retinopathy have changes in their coagulation & fibrinoly負ic system predisposing to bleeding or to vas苞ular occlusion and ascertain any relationship between them so that this may be a guideline for the early diagnosis and management of the potential case of diabetes who might develop retinopathy at a later stage.


  Materials and methods Top


The study consisted of three groups of indi赳iduals. Each group had 20 individuals. In group A twenty healthy subjects were taken as control. Group B comprised of patients of diabetes mellitus retinopathy add group C included patients of diabetes mellitus with retinopathy. All patients were from the medi苞al wards of Medical College Hospital, Udai計ur. The criteria of diagnosis were a typical history, certain physical findings and chiefly presence of sugar in urine and high fasting blood sugar level. Fundus examination was done under full mydriasis.

Urine sugar examination, blood sugar (som觔gyii-Nelson method), plasma fibrinogen esti衫ation euglobin englobinl ysistime were estimated each and statistical analysis of the results was compiled.


  Observations and discussion Top


It ranged, in control cases from 189.47 mg % to 383.68 mg % in group B from 268.42 mg % to 510.53 mg % and in group C from 321.05 mg % to 626.32 mg%.

This show that the plasma fibrinogen level was high in diabetics without retinopathy than control and still higher in diabetics with retinopathy.

It ranged in control cases from 60.50 units to 86.96 units, in group B from 40.82 units to 86.96 units and in group C from 31.25 units to 57.14 units.

Further more [Table - 3][Table - 4] shows that mean fibrinogen level was higher in cases of diabetes with retinopathy, who were having retinal haemorrhage than in cases who were not having retinal haemorrhages. Meen fibrino衍ytic activity was found to be low in cases.who were having haemorrhages.

The plasma fibrinogen level in withont retinopathy group and retinopathy group were significantly higher (P<0.001 ) than control. The values were also significantly higher (P<0.001 ) in retinopathy group than in with觔ut retinopathy group. (For 38 degrees of freedon, at 0.1% level of significance the value of `t' is 3.6 as found on reference to `t' table.

(`t' = 3.6, P < 0.001, significant at 0.1% level). In the same way mean fibrinolytic activity in without retinopathy group was significantly lower (P<0.001 ), than controls.

The mean fibrinolytic activity was also signifi苞antly lower ( P<0.001 ) in retinopathy group than without retinopathy group.

Our results supports along with others, the observations of Lars Olof Almer (1975), who studied 135 patients with and without retino計athy and found that mean fibrinolytic activity was 28.2 S. E. 2.8 mm 2 lysis (Fibrin plate method), compared with 34.4 + 3.3 in the controls).

This study show that retinopathy in diabe負ic patients is accompanied by quantitative changes of the components of the fibrinolyitc system, thereby giving an apportunity for early diagnosis and management of the case as microangiopathy is generalised and gives an idea of renal changes even in the absence of proteinuria. (dewardener 1967).

It is very likely that thromboemblic occlu貞ion of the microvasculature might be caused by a disturbance of the delicate equilibrium between coagulation and fibrinolysis.



 
 
    Tables

  [Table - 1], [Table - 2], [Table - 3], [Table - 4]



 

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