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   Table of Contents      
ARTICLES
Year : 1983  |  Volume : 31  |  Issue : 7  |  Page : 992-994

Clinical evaluation of tromaril as an anti-inflammatory agent in ophthalmic practice


Department of Ophthalmology and Department of Pharmacology, Dr. VM Medical College, Solapur, India

Correspondence Address:
A G Chandorkar
Department of Pharmacology, Dr. V.M. Medical College, Solapur 413 003. Maharashtra State
India
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Source of Support: None, Conflict of Interest: None


PMID: 6544304

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How to cite this article:
Albal M V, Pradhan U R, Chandorkar A G. Clinical evaluation of tromaril as an anti-inflammatory agent in ophthalmic practice. Indian J Ophthalmol 1983;31, Suppl S1:992-4

How to cite this URL:
Albal M V, Pradhan U R, Chandorkar A G. Clinical evaluation of tromaril as an anti-inflammatory agent in ophthalmic practice. Indian J Ophthalmol [serial online] 1983 [cited 2020 May 24];31, Suppl S1:992-4. Available from: http://www.ijo.in/text.asp?1983/31/7/992/29726

Table 3

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Table 3

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Table 2

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Table 2

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Table 1

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Table 1

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Tromaril is an anthranilic acid derivative with potent anti-inflammatory, anti-arthritic, analgesic and antipyretic actions. It has additional unique property of anti-platelet aggregation activity, without disturbing any other blood coagulation factors. It also differs from other non-steroidal anti-inflammatory agents like indomethacin, in producing diuresis and natriuresis.

Tormaril is very effective in the treatment of acute swellings due to trauma or postopera­tive tissue injury. In case of infections leading to inflammation of various tissues. Tromaril by its anti-inflammatory and anti-edema pro­perty forms a very useful adjuvant to chemotherapy and reduces the pain and dis­comfort of the patient. Therefore, it was decided to evaluate the therapeutic efficacy and tolerability of Tromaril, and to compare its anti-inflammatory and analgesic property with that of oxyphenbutazone in ophthalmic inflammatory conditions.


  Material and methods Top


One hundred and twenty patients with either inflammatory or ulcerative conditions or operated for cataracts, glaucoma or squint [Table - 1] were allotted serialy to either group in an opern trial. Tromaril or oxyphen­butazone was administered in a does of 1200 mg per day and 300 mg per day respectively.

Clinical assessment was done both subjec­tively and objectively before and after treat­ment. The parameters for clinical evaluation like pain, oedema, tenderness, congestions, were graded as: severe as 4, moderate to severe as 3, moderate as 2, mild as 1 and nil as 0.

Side effects were graded as severe - 3, mod­erate - 2, mild - 1 or nil - 0, while patients acceptance was scored as excellent --- 4, good - 3, fair - 2 and poor - 1. An over all assess­ment was made to decide the effieacy of the drug and graded as : highly effective as - 4, effective as - 3, moderately effective as - 2 and ineffective as - 1.


  Observations Top


Pain and tenderness was reduced by second day with from severe or from maderate to severe, to mild or moderate degree. concommitant significant reduction in congestion and swelling. By the end of fourth day no pain Tendernessor was seen and sign of inflammation subsided in 83% patients treated with tromaril and in 80% patients trated with oxyphenbutazone. By the sixth day about 98% and 93% patient." on Tromaril and oxyphenbutazone respec­tively were clinically free from inflammation [Table - 2]. Very few patients needed any adjuvant antibiotic therapy. Patients acceptance was excellent in most of the cases and no side effects were seen either with tromaril or oxyphenbutazone. Both the druges were highly effective (Tromaril - 83°6, and oxphenbutazone - 70%) and no signifi­cant difference was seen in over all essessment [Table - 3].


  Discussion Top


Tromaril, in a double blind trial in episiotomy patients showed a highly signifi­cant anti-inflammatory and analgesic effect with the same degree of therapeutic efficacy and tolerability as oxyphenbutazone[1],[2],[3]. sub Similar results have been obtained in dental surgery[4]. Our results in ophthalmic patients are also in confirmity with the above.

The role of prostaglandin in inflammation is well known. Tromaril is shown to inhibit the prostaglandin synthetase[5] and hence the likely mechanisms of its anti-inflammatory activity could be prostaglandin synthetase inhibition, leading to decreased prostaglan­din synthesis and release.

Tromaril is devoid of gastric irritation or other side effects and is well accepted by the patient. Like oxyphenbutazone it does not interact with anticoagulants or oral anfid­iabetic agents, so its use would be safer in patients on above drug regimens who develop ulcerative or inflammatory conditions in the eye.


  Summary Top


Tromaril an anti-inflammatory, analgesic and antipyretic agent was evaluated by an open trial in ophthalmic postoperative, ulcerative and inflammatory conditions. It was found to be as effective as oxyphen­butazone and no took effects were seen.


  Acknowledgement Top


We are grateful to Dr. J.H. Balwani, Medi­cal Adviser, Unichem Lab. Pvt. Ltd. for the supply of drugs and to the Dean, Dr. V.M. Medical College, Solapur for facilities.

 
  References Top

1.
Lokabai, N., and Reddy, D., 1980, Jr. Asso. Phys. Ind., (Special suppl.), 28:118.  Back to cited text no. 1
    
2.
Punjabi, J., Krishna, U.R., Paul, T. and Sheth U.K., 1980 Jr. Asso. Phys. Ind., (Special Supply), 28:115.  Back to cited text no. 2
    
3.
Vacharajani, G.M., Gupta, K.C., Paul, T., and Sheth, U.K., 1980, Jr. Asso. Hpys. Ind. (special Supply), 28:127.  Back to cited text no. 3
    
4.
Chitra,A.R, and Hussain, T., 1980 Jr. Asso. Phys.Ind. (Special Suppl), 28:129.  Back to cited text no. 4
    
5.
Kshirsagar, NA, Athanikar, N. Jha, A, and Sheth, U.K, .1980 Jr. Asso. Phys. Ind., (Special Suppl), 28:39.  Back to cited text no. 5
    



 
 
    Tables

  [Table - 1], [Table - 2], [Table - 3]



 

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  In this article
Material and methods
Observations
Discussion
Summary
Acknowledgement
References
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