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ORIGINAL ARTICLE
Year : 1987  |  Volume : 35  |  Issue : 3  |  Page : 141-145

Study of topical corticosteroid response in glaucoma suspects and family members of established glaucoma patients


AMU Institute of Ophthalmology, Aligarh, India

Correspondence Address:
F A Jilani
AMU Institute of Ophthalmology, Aligarh
India
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Source of Support: None, Conflict of Interest: None


PMID: 3507409

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The present study was conducted to study the topical steroid response in glaucoma suspects and family members of established glaucoma patients and its hereditary pattern The cases understudy were divided into three groups, namely normal (25 cases), suspected open angle glaucoma cases (20) and family members of established open angle glaucoma cases (33). After preliminary examination each patient was advised to put dexamethasone drop 1 % in one eye and a placebo in other eye. The IOP was noted after three weeks It was found that 80% of all eyes under study showed a rise in IOP after use of topical dexamethasone. The highest mean IOP was found in primary open angle glaucoma suspects, and the highest mean post-corticosteroid rise in IOP of 8.91 mm Hg was found among family members of established open angle glaucoma patients. The lOP response to topical corticosteroids was found to be of three phenotypical types viz., poor responders (nn), moderate responders (ng) and high responders (gg). Normal subjects were generally poor responders. Suspected open angle glaucoma cases were generally high responders. However, family members of established open angle glaucoma cases showed the highest percentage of presence of responder gene.


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