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Year : 1988  |  Volume : 36  |  Issue : 2  |  Page : 95-97

Topical antibiotics in the management of corneal ulcer

Superintendent, S. D. Eye Hospital, Hyderabad, India

Correspondence Address:
P Ranga Reddy
Superintendent, S. D. Eye Hospital, Hyderabad
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Source of Support: None, Conflict of Interest: None

PMID: 3069735

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A total of 82 patients suffering from corneal ulcer were treated with framycetin 0.5%, gentamicin 3 mg./ml, chloramphenicol 0.4% and a neomycin combination containing Polymixin B sulphate 5000 u, neomycin sulphate 1700 u and gramicidin 0.025 mg/mL in a Randomised comparative study. The commonest organism isolated was Staphylococcus followed by Pneumococcus, Streptococcus and Pseudomonas. The in vitro sensitivity of these isolates to framycetin was higher than that to others Framycetin produced both earlier and a greater degree of improvement in mean score of signs and symptoms than the other antibiotics. It can thus be concluded that framycetin has a better profile of antibacterial activity and clinical efficacy than some other commonly used topical antibiotics in the treatment of corneal ulcer.

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