Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 10958
  • Home
  • Print this page
  • Email this page

   Table of Contents      
CASE REPORT
Year : 1992  |  Volume : 40  |  Issue : 2  |  Page : 63-65

Angiomatoid malignant fibrous histiocytoma of the eyelid


1 Department of Ophthalmology, King George's Medical College, Lucknow, India
2 Department of Pathology & Bacteriology, King George's Medical College, Lucknow, India

Correspondence Address:
Sandeep Saxena
G-19, River Bank Colony. Lucknow
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 1333444

Rights and PermissionsRights and Permissions
  Abstract 

A 20 year old female had an angiomatoid malignant fibrous histiocytoma of her left upper eyelid extending into the orbit, frontal and temporal regions. The tumor was excised and radiotherapy was given. Nine months follow-up did not reveal any recurrence.


How to cite this article:
Nath R, Saxena S, Agarwal PK, Roy S. Angiomatoid malignant fibrous histiocytoma of the eyelid. Indian J Ophthalmol 1992;40:63-5

How to cite this URL:
Nath R, Saxena S, Agarwal PK, Roy S. Angiomatoid malignant fibrous histiocytoma of the eyelid. Indian J Ophthalmol [serial online] 1992 [cited 2020 Feb 20];40:63-5. Available from: http://www.ijo.in/text.asp?1992/40/2/63/24410


  Introduction Top


Malignant fibrous histiocytoma is a primitive mesenchymal tumor showing partial fibroblastic and histiocytic differentiation [1]. Angiomatoid malignant fibrous histiocytoma was first described by En­zinger [2] (1979). It is a rare tumor that combines features of both a fibrohistiocytic and a vascular neoplasm [2]. It is a less aggressive tumor of children and young adults, arising most commonly from the dermis and subcutis of the extremities [3]. Fibro-his­tiocystic malignancies occurs more commonly in males than in females [1],[4],[5][6]. Metastasis occurs in the lungs and lymph nodes [1],[7]. Recurrence is frequent after excision [7],[8],[9]. In our knowledge, angiomatoid malignant fibrous histiocytoma of the upper eyelid extending into the peripheral orbital space, frontal and temporal regions, in a young female, is being reported for the first time.


  Case report Top


A 20-year old female was admitted with a seven month history of a painless and gradually progressive swelling which started from the lateral one third of the left upper eyelid. Initially, the mass was excised elsewhere. Two months after this excision the swelling recurred at the same site, increased in size and spread laterally and superiorly till her presentation at this centre. Her general health was good.

Her unaided visual acuity was R.E. 6/6 and L.E. 6/12. A firm, ill-defined, non tender mass measuring 6 X 4 cm was present in the left upper eyelid. The overlying skin had a bluish tint and prominent veins. Mechanical ptosis of the left upper eyelid was present [Figure - 1]. The tumor mass extended into the temporal and frontal regions, where it was fixed to the un­derlying structures. The left eyeball was deviated inferonasally, but proptosis was not present. The .anterior and posterior segments of the eye were normal. The right eye and its adenexae were normal. X-ray skull and chest did not reveal any abnormality.

C.T scan showed a nonhomogenous soft tissue mass of the left upper eyelid infiltrating into the anterior part of outer peripheral orbital space, frontal and temporal regions. The eyeball was displaced nasally. Adjoining frontal and zygomatic bones were thickened.

Surgical excision of the mass was done under general anaesthesia. The adjoining periostium of the orbit found to be involved, was removed. Deviation of the eyeball improved after surgery. Postoperative radiotherapy, 4000 CGY/20 fractions (anterior and lateral wedge field were given for four weeks by external beam Co 60. A nine month follow-up did not reveal any recurrence.


  PATHOLOGIC FINDINGS: Top


The tumor mass was 6 X 4 X 3 cms. in size and lobulated. The cut surface was gray white interspersed with haemorrhagic areas. Many irregular blood filled cystic spaces [Figure - 3] were also seen. Multiple paraffin sections were prepared for histopathological examination. All the sections were stained with routine hematoxylin and eosin. Sections revealed multiple haemorrhagic spaces simulating vascular spaces. These were lined by spindle shaped and histiocytic cells [Figure - 4][Figure - 5]. The cells were highly pleomorphic and contained scanty to moderate amount of cytoplasm. Nuclei were also of variable sizes [Figure - 6].


  Discussion Top


The orbit is a site of predilection for fibrous his­tiocytoma[7],[10].The eyelid is an unusual location for fibrous histiocytoma[11]. John, Yanoff & Scheie [11] (1981) reported fibrous histiocytoma of the lower eyelid. Ronan and Tso[12] (1978) reported a unique case of bilateral multiple pert-orbital fibrous histiocytoma with extensive involvement of the lids.

Angiomatoid malignant fibrous histiocytoma of the orbit has been reported in a 7 years old boy by Cabellero, Rodriguez and Sopelana[13]sub(1981). To the best of our knowledge, it has not been reported from the eyelids previously. Clinically, the bluish tint of the tumor and the blood filled spaces on the cut surface suggested a vascular tumour but the histologic characteristics were consistent with the diagnosis of angiomatoid malignant fibrous histiocytoma.


  Acknowledgement Top


We are thankful to Prof. R.C. Saxena for his guidance in preparing this paper. We are also thankful to Mr. P.C. Roy for his assistance in photography.

 
  References Top

1.
Weiss, S.W.. Enzinger FM. Malignant Fibrous Histiocytoma: An analysis of 200 cases. Cancer 1978: 41:2250-66  Back to cited text no. 1
    
2.
Enzinger, F.M.: Angiomatoid Malignant Fibrous Histiocytoma: A distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer 1979: 44 2147-57.  Back to cited text no. 2
    
3.
Enzinger. FM : Weiss. S W. Soft tissue tumors. St Louis. C.V. Mosby Company, 1983. pp 166-196  Back to cited text no. 3
    
4.
O Brien. J.E.: Stout. A. I? Malignant Fibrous Xanthomas. Cancer 1964: 17 1445-58.  Back to cited text no. 4
    
5.
Soule. E.H.: Enriquez. P. Atypical fibrous histiocytoma. malignant histiocytoma and epitheloid sarcoma. A comparative study of 65 tumors. Cancer 1972. 30: 128-1,43.  Back to cited text no. 5
    
6.
Weiss, S.W : Enzinger, FM.: Myxoid variant of malignant fibrous histiocytoma. Cancer 1977: 39: 1672-85  Back to cited text no. 6
    
7.
Font. R.L.: Hidavat. A. A.: Fibrous histiocytoma of the orbit. A clinicopathologic study of 150 cases. Human Pathol. 1982: 13 (3): 199-209.  Back to cited text no. 7
    
8.
Litricin O: Fibrous histiocytoma of the corneosclera. Arch Ophthalmol. 1983. 101: 426-28.  Back to cited text no. 8
    
9.
Delgado-Partida. P; Rodriguez-Trujillo. F.: Fibrosarcoma (Malignant fibroxanthoma) involving conjunctiva and ciliary body. Am. J. Ophthalmol. 1972: 74: 479-85..  Back to cited text no. 9
    
10.
Jakobiec. FA.: Howard, G.N.: Jones. I.S ; Tannenbaum, M : Fibrous histiocytoma of the orbit. Am. J Ophthalmol. 1974, 77' 333-45.  Back to cited text no. 10
    
11.
John. T.: Yanoff, M.; Scheie, H.G : Eyelid fibrous histiocytoma• Ophthalmology. 1981, 88: 1193-95.  Back to cited text no. 11
    
12.
Ronan. S. G.: Tso MOM: Multiple periorbital fibrous histiocytomas. A light and electron microscopic study. Arch. Dermato4. 1978. 114. 1345-47.  Back to cited text no. 12
    
13.
Cabellero. LRC. Rodriguez. AC.; Sopelana. A.B. An (Angiomatoid malignant fibrous histiocytoma of the orbit. Am J Ophthalmol 1981: 92 13-15­  Back to cited text no. 13
    


    Figures

  [Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4], [Figure - 5], [Figure - 6]


This article has been cited by
1 Malignant fibrous histiocytoma of the eyelid: Case report | [Fibro-histiocitoma maligno da pálpebra: Relato de caso]
Dias, A.C.T., de Sousa Pereira, L., Sameshima, L.M., Costa Reis, F.A., Filho, J.V.
Arquivos Brasileiros de Oftalmologia. 2009; 72(1): 109-112
[Pubmed]
2 Fibrous histiocytoma of the eyelid obliterating the punctum and the canaliculus
Pyatetsky, D., Lissner, G.S., Bryar, P.J., Lasky, J.B.
Journal of Pediatric Ophthalmology and Strabismus. 2007; 44(6): 379-381
[Pubmed]
3 Angiomatoid variant of fibrous histiocytoma: A case report and review of literature
Pratibha, R., Ahmed, S.
International Journal of Paediatric Dentistry. 2006; 16(5): 363-369
[Pubmed]
4 Angiomatoid fibrous histiocytoma arising in the mediastinum
Seethala, R.R., Moran, C.A.
Pathology Case Reviews. 2006; 11(5): 222-225
[Pubmed]
5 Malignant fibrous histiocytoma of the eyelid: Differential diagnosis and management
Khong, J.J., Chen, C.S., James, C.L., Huilgol, S.C., OæDonnell, B.A., Sullivan, T.J., Selva, D.
Ophthalmic Plastic and Reconstructive Surgery. 2005; 21(2): 103-108
[Pubmed]
6 Orbital malignant fibrous histiocytoma with extension to the base of the skull - Case report
Ueda, R., Hayashi, T., Kameyama, K., Yoshida, K., Kawase, T.
Neurologia Medico-Chirurgica. 2003; 43(5): 263-266
[Pubmed]
7 Benign pleomorphic fibrous histiocytoma of the eyelid: Report of two cases
Bryant, J.
Annals of Ophthalmology - Glaucoma. 1997; 29(1): 40-42
[Pubmed]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Abstract
Introduction
Case report
PATHOLOGIC FINDINGS:
Discussion
Acknowledgement
References
Article Figures

 Article Access Statistics
    Viewed2720    
    Printed99    
    Emailed3    
    PDF Downloaded0    
    Comments [Add]    
    Cited by others 7    

Recommend this journal