Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 1602
  • Home
  • Print this page
  • Email this page


 
   Table of Contents      
CURRENT OPHTHALMOLOGY
Year : 1994  |  Volume : 42  |  Issue : 1  |  Page : 3-18

Eales' disease


1 L.V. Prasad Eye Institute, Hyderabad, India
2 Sankara Netralaya, Madras, India
3 RP Centre for Ophthalmic Sciences, New Delhi, India
4 Retina Foundation, Ahmedabad, India
5 Aravind Eye Hospital, Madurai, India
6 Retina Associates, New Delhi, India

Correspondence Address:
Taraprasad Das
L.V. Prasad Eye Institute, Road No.2, Banjara Hills, Hyderabad 500 034
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 7927628

Rights and PermissionsRights and Permissions

How to cite this article:
Das T, Biswas J, Kumar A, Nagpal P N, Namperumalsamy P, Patnaik B, Tewari H K. Eales' disease. Indian J Ophthalmol 1994;42:3-18

How to cite this URL:
Das T, Biswas J, Kumar A, Nagpal P N, Namperumalsamy P, Patnaik B, Tewari H K. Eales' disease. Indian J Ophthalmol [serial online] 1994 [cited 2017 Sep 21];42:3-18. Available from: http://www.ijo.in/text.asp?1994/42/1/3/25586



Click here to view


Click here to view


Click here to view


Click here to view


Click here to view


Click here to view


Click here to view


Click here to view


Click here to view


Click here to view


Click here to view


Click here to view


Click here to view


Click here to view

  I. INTRODUCTION Top


Eales' disease is an idiopathic inflammatory venous occlusion that primarily affects the peripheral retina of adults. Retinal changes include perivascular phlebitis, peripheral nonperfusion, and neovascularization. Visual loss is characteristically caused by bilateral recurrent vitreous haemorrhage and its sequelae.

In 1880 and 1882 Henry Eales', [1],[2] a British ophthalmologist described the clinical picture of recurrent retinal haemorrhages in young adults. His seven patients were all young men (age, 14 to 29 years). They had in common a history of headache, epistaxis, variation in peripheral circulation, dyspepsia, and chronic constipation. Eales believed it to be a vasomotor neurosis wherein constriction of the alimentary vessels and compensatory dilatation of those of the head, lead to rupture of retinal and nasal vessels with consequent haemorrhage. However, retinal vasculitis was not described by Eales. Wadsworth [3] described the associated signs of retinal inflammation five years later.

In the century that has followed, Henry Eales has been honoured with the eponym for the disease characterized by idiopathic recurrent vitreous haemorrhage in otherwise young and healthy adults. The eponym has been retained because of its widespread recognition and the emphasis that it gives to the common clinical features and certain significant therapeutic implications.

Since Eales' disease was originally thought to be a disease of retinal veins, Elliot [4] initially suggested that the disease be called "periphlebitis retinae." However, near equal prevalence of venular and arteriolar inflammation was later documented and hence, Kimura et al, [5] Keith Lyle and Wybar [6] , and Cross' preferred to call it "retinal perivasculitis" or even "retinal vasculitis" since the vessel wall itself is involved in inflammation and not merely its surrounding connective tissue.


  II. PATIENT PROFILE Top


Eales' disease has been reported from the United kingdom, the United States, and Canada in the later half of 19th and early 20th century. But for unknown reasons, it is now rare in more developed countries and is more commonly reported from the Indian subcontinent. The reported incidence in India is one in 200 to 250 ophthalmic patients. [8]

Eales' disease predominantly affects healthy young adults. Most investigators note a male predominance. The peak age of onset of symptoms is 20 to 30 years. Most patients' symptoms include vitreous haemorrhage, such as small specs, floaters, cobwebs, blurring, or decrease of visual acuity. Others have blurring of vision associated with retinal vasculitis but without vitreous haemorrhage. Many patients complain of symptoms in only one eye, but detailed fundus examination of the fellow eye reveals the early changes associated with Eales' disease such as periphlebitis, vascular sheathing, or peripheral nonperfusion. Eventually, between 70 to 80% of patients develop bilateral involvement though the extent of retinal involvement may not be to the same extent. Duke-Elder' noted 90% bilateral retinal involvement and others [10] have noted only 50% bilateral involvement.


  III. CLINICAL PICTURE Top


Eales' disease is characterized by retinal phlebitis, peripheral nonperfusion, and retinal neovascularization.

A. Retinal Phlebitis

Intraocular inflammation is a common manifestation of Eales' disease. Signs and symptoms of inflammation occur at varying times in the course of the disease, but are less common in late stages. Fundus examination in the early stages of the disease reveals venous dilatation in the periphery with tortuosity and discontinuity of veins. Perivascular exudates are seen along the peripheral veins [Figure - 1]. Vascular sheathing ranges from thin white lines limiting the blood column on both sides to heavy exudative sheathing. The thin white lines tend to be continuous, and the heavy exudative sheathing is usually segmental. Superficial flame-shaped haemorrhages are often located in the areas of sheathed vessels [Figure - 2]. Though not initially involved, at a later stage the arteries also attenuate in the periphery. The involved vessels become obliterated and an avascular area develops in the periphery which is better visualized by fluorescein angiography. Areas of vascular sheathing frequently leak fluorescein dye; however, the sheathing does not always correspond to the staining.

The intensity of the dye leakage seen with fluorescein angiography is not always proportional to the activity of the inflammatory process.

B. Peripheral Nonperfusion

Most patients with Eales' disease develop varying degrees of peripheral retinal nonperfusion [Figure - 3]. Intraretinal haemorrhages often first appear in the affected area, followed by an increase in vascular tortuosity with frequent collateral formation around occluded vessels. Fine solid white lines representing the remains of obliterated large vessels are commonly seen in the area of nonperfusion [Figure - 4]. These fine lines retain configuration of normal retinal vasculature.

This junction between the anteroperipheral nonperfusion and the posterior perfused retina is usually sharply demarcated.

The vascular abnormalities at the junction between the perfused and nonperfused zones include microaneurysms, veno-venous shunts, venous beading and occasionally hard exudates and cotton-wool spots. [11],[12]

C. Neovascularization

Neovascularization is observed in upto 80% of patients with Eales' disease. The new vessels can form either on the disc (NVD) or elsewhere on the retina (NVE) [Figure - 5]a [Figure - 6].

The NVE, however, is usually more common than NVD and is usually located at the junction between the perfused and nonperfused retina.

Bleeding from neovascularization is common, usually recurrent, and is one of the major causes of visual loss. A few days after vitreous haemorrhage, blood settles in the lower vitreous, and fundus details become visible again. In favourable cases, there may not be any recurrence after the first episode of vitreous haemorrhage. In recurrent bleeding, the fundus shows evidence of old blood, with signs of fibrous organization, retinitis proliferans or even tractional retinal detachment. Some patients may develop uveitis,

complicated cataract, rubeosis iridis, and secondary neovascular glaucoma in the late stage of the disease.

In a study of fundus details of 144 eyes, Abraham et a1 [13] have noted periphlebitis and sheathing of vessels in 84% of eyes, kinky tortuous venules and irregularity in caliber of vessels in 37% of eyes, pigmentation in the course of or at bifurcation of vessels and circumscribed pigmented areas suggestive of healed chorioretinitis in 35% of eyes, surface NVE or neovascular vitreous fronds in 50% of eyes, and vitreous haemorrhage in 34% of eyes.

Other vitreous abnormalities seen in Eales' disease are vitreous condensation and posterior vitreous detachment.

The macula is usually not involved primarily in Eales' disease despite extensive peripheral nonperfusion. This preserves the central vision. However, in some patients the nonperfusion extends to the macula or macular oedema develops [Figure - 7][Figure - 8].

In eyes after recurrent vitreous haemorrhages with extensive fibrosis, the optic disc becomes pale, arteries and veins become narrow, leading eventually to secondary optic atrophy.

D. Fluorescein Angiography

Being essentially a retinal vascular disease, the various manifestations of Eales' disease are ideally studied by fluorescein angiography. [14],[15] Active vasculitis is characterized by staining of the vessel wall or even frank extravasation. Vascular sheathing due to gliosis without active inflammation do not show these features. Inflammation of the venous segments result in various degrees of obstruction to the venous flow. Even after the inflammation has subsided, very often reduced venous outflow persists.

Venous stasis consequent to venous obstruction is manifested by engorged tortuous veins distal to the obstruction, engorgement of the capillary bed, microaneurysms, and of course, retinal haemorrhages and retinal (especially macular) oedema. However, in fresh cases, retinal haemorrhage may mask the microvascular changes. The retinal oedema is characterized by increased permeability and diffuse extravasation of the dye. The newly formed blood vessels become distinctly outlined during the arteriovenous phase with their abnormal branching patterns. These soon begin to leak the dye [Figure - 9]a and b.

Fluorescein angiography also helps in monitoring the regression and disappearance of new vessels during treatment and follow-up [Figure l0]a and b. Following subsidence of the venous inflammation, the dye leakage and later the dye staining stops. The dilated and tortuous blood vessels form, in part, the veno­venous shunt system. These shunt vessels divert venous blood from the involved to the neighbouring venous territory. Ordinarily, these do not leak fluorescein. Often one notices patches of deep choroiditis along the inflamed veins in various stages of development and healing.


  IV. NATURAL COURSE Top


The natural course of Eales' disease is quite variable with temporary or even permanent remission in some cases and relentless progression to total blindness in others. The diagnostic clinical picture of Eales' disease is the evidence of peripheral venous inflammation, past or present. Active inflammation is manifested by characteristic perivascular clustering, which could be mild or massive, isolated or multiple. Inflammation of the vein causes variable degrees of venous insufficiency.

Retinal ischaemia stimulates neovascular growth from the surrounding normal vasculature. The common site is just proximal to the site of obstruction. When there are extensive areas of retinal ischaemia, over and above the peripheral new vessels (NVE), one also finds disc neovascularization (NVD). In some cases, where both arterioles and venules are involved extensively, one may find disc new vessels alone. The retinal and disc new vessels are the most important cause of repeated vitreous haemorrhage. Occasionally with time, there is a tendency for the new vessels to regress. More and more of neovascular lesions tend to become sclerosed and stop perfusing with blood. Ultimately the regressed new vessels get replaced by glial tissue. The glial tissues on contraction cause several retinal complications.

The macula may get distorted or detached. The regressing new vessels often get pulled into the vitreous. Usually a tear develops at the point where the venule draining the neovascular lesion joins the retina [Figure - 11]. This leads to rhegmatogenous retinal detachment.

Though this is a clinical course of a classical case, not all cases of phlebitis lead to neovascularization, vitreous haemorrhage, and retinal detachment. What exactly determines the variable course of Eales' disease is not yet known.

Charmis [16] in 1965 classified Eales' disease into four stages on the basis of its evolution and prognosis. Stage I is the very early stage of evolution and is characterized by mild periphlebitis of small peripheral retinal capillaries, as detected by ophthalmoscopy. Perivasculitis of the venous capillary system is widespread and larger veins are also affected in stage II. New vessel formation with abundant haemorrhage in the retina and vitreous is seen in stage III and the stage IV is the end result of massive and recurrent vitreous haemorrhages with retinitis proliferans and tractional retinal detachment.

Das and Namperumalsamy [17] have proposed a different system of grading Eales' retinopathy based on the degree and extent of microangiopathy, proliferative retinopathy, and vitreous haemorrhage [Table - 1]. This classification was useful in assessing and monitoring the effect of treatment in Eales' disease.

In a longitudinal study of 50 cases of Eales' disease by repeated fundus examination and fluorescein angiography over a period of six to fourteen months, Kalsi and Patnaik [18] have hypothesized the probable natural course of the Eales' disease, leading either to circulatory stabilization or repeated vitreous haemorrhages (RVH) [Figure - 12]. Accordingly, there are 3 different ways by which vitreous haemorrhage can occur. First, acute phlebitis with rapid or sudden obstruction to the venous flow can cause a haemorrhage large enough to break into the vitreous. When a large caliber vein is involved the haemorrhage can be massive, which may not clear for months. Secondly, when a smaller peripheral venule is involved, haemorrhage is relatively small and gets absorbed with time. Occasionally, sequential acute involvement of small caliber venules lead to repeated vitreous haemorrhage. Lastly, persistent state of circulatory deficiency and retinal ischaemia may lead to neovascular proliferation which is the commonest source of repeated vitreous haemorrhage.

Peripheral circulatory deficiency manifests as microaneurysms, residual haemorrhages, capillary engorgement or capillary closures. Occasionally, in course of time, circulatory stabilization may ensue through recanalization, venovenous capillary shunts and tissue atrophy.


  V. AETIOPATHOGENESIS Top


The aetiopathogenesis of Eales' disease to date has remained controversial and ill-understood. Since the description of Wadsworth, [3] Eales' disease is recognized as primary vasculitis of unknown aetiology occurring in young adults. Duke-Elder, [9] however, felt that Eales' disease is not a specific entity but is a manifestation of many diseases.

Retinal vasculitis and peripheral retinal neovascularization associated with various systemic and ocular diseases could mimic Eales' disease in the inflammatory and the proliferative phases, respectively [Table - 2][Table - 3].

Therefore, there is a need to distinguish Eales' disease from several other entities. There are certain peculiarities of this disease, e.g. male preponderance, occurrence in healthy young adults, predominant involvement of the peripheral retina, and specific geographic and ethnic predilection, which are still not explained. Whether they indicate a specific aetiology is a matter of debate.

While the aetiopathogenesis of this disease remains obscure since its description, various studies have been done to identify the aetiology, which can be classified as follows:

A. Systemic diseases associated with Eales' disease

B. Immunological studies in Eales' disease

C. Biochemical studies in Eales' disease

A. Systemic Diseases Associated with Eales' Disease

Since the description of Henry Eales, association of Eales' disease with several systemic diseases has been reported [Table - 4]. However, in large series many such associations have not been proved. Most of these associations are occasional and do not merit extensive discussion. However, since tuberculosis has often been directly or indirectly implicated, a brief survey of the literature and the possible causal association is justified.

Tuberculosis

Among the several diseases or systemic abnormalities found to be associated with Eales' disease, tuberculosis has been favoured by many. However, only two studies [50],[51] have histopathologically demonstrated the presence of tubercle bacilli in the pathologic specimens. Based on the probable aetiological association with tuberculosis, Finoff [52] injected tubercle bacilli into the homolateral carotid artery of 46 experimental animals and produced periphlebitis in only one of them. The animal, however, had concurrent iridocyclitis. Several others have so far not succeeded in producing the same. The assumption of tubercular aetiology is based on observations of active or healed tuberculosis in some patients of Eales' disease. However, when ophthalmological evaluation was done in a large number of Indian patients of active or healed tuberculosis, Eales' disease was seen only in 1.3% of them." The role of tuberculosis as an aetiological agent at this point is still not established. Probably, some cases of phlebitis where one finds massive infiltration, nodule formation, and complete obliteration of venous segments are tubercular in origin. Clinically, these patients respond to ATT regimen (BP, PNN­personal experience).

Hypersensitivity to Tuberculoprotein

Apart from tuberculosis, allergic reaction to tuberculoprotein has been considered by several authors till date. This is based on observation of positive Mantoux reaction, which is as high as 90% in some series . [25],[26 ] Tuberculin hypersensitivity develops following exposure to tuberculosis. Cutaneous sensitivity is known to give a fairly reliable index of ocular sensitivity in experimental animals infected with tuberculosis. Ashton [19] hypothesized that the retina of patients with Eales' disease could be selectively sensitized against tuberculoprotein. Re-exposure to this antigen could result in allergic vasculitis in the retina.

However, Eales' disease has also been reported in Mantoux-negative patients.-' In India, Mantoux test has been found to be positive in 67 to 90% of healthy adults. This raises doubt regarding validity of the role of tuberculoprotein.

Other Systemic Diseases

Several reports have shown association of a variety of neurological [31][32][33][34][35] and haematological disorders [37][38][39][40][41][42][43][44][45] with Eales' disease. Renie et al [46] reported sensoryneural hearing loss in patients with Eales'disease that could not be later substantiated in a case-control study. [46a]

B. Immunological Studies in Eales' Disease

Immune-mediated mechanism has been proposed by many authors [51][52][53] as a possible cause of Eales'disease [Table - 5]. The clinical picture of acute onset, favourable response to systemic steroid, lymphocytic infiltration in histopathologic study of the vitreous and epiretinal membranes and abnormal immunological parameters observed in retinal vasculitis similar to Eales' retinopathy, all indicate an immunological mechanism involved in Eales' disease. However, so far, a precise immunological mechanism has not been identified.

Muthukaruppan et all' studied various immunological parameters in 100 patients of Eales' disease and found no difference in immunoglobulin levels, T lymphocyte subsets and antibody response to BCG antigen and S-antigens. The authors hypothesized that an altered immune response of type III (immune complex mediated) and/or type IV delayed hypersensitivity reaction to an infectious agent probably leads to retinal changes in Eales' disease.

Koliopoulos et al [56] studied immunoglobulin levels in 5 patients of Eales' disease and found no abnormality. Mean level of IgM was low. However, Johnson et al [57] found raised IgG and IgA levels in 4 of their patients with Eales' disease. Andrew et al-" studied circulating immune complexes of 27 patients and found abnormal levels of more than one circulating immune complexes in patients with Eales' disease. Bertrams et a1 [59] have studied 19 HLA-A antigens and 15 HLA-B antigens in 48 patients of Eales' disease but did not find any significant association with these HLA class I antigens. However, no study has been done to demonstrate any association with class II HLA antigens, especially HLA-DR antigens.

Recent immunological studies [60][61][62][63][64][65][66] done on retinal vasculitis associated with systemic diseases and idiopathic retinal vasculitis which mimic Eales' disease can provide several important clues in understanding the immunogenic mechanism involved in this disease. Kasp at a1 [60] found elevated levels of circulating immune complexes and antiretinal antibody in various groups of idiopathic retinal vasculitis. They concluded that both antiretinal autoimmunity and circulating immune complexes may act as immunopathogenic factors in idiopathic retinal vasculitis and in certain patients circulating immune complexes seem to protect against a more severe form of autoimmune retinal inflammatory disease. Edelsten et a1 [61] found 47% of patients of retinal vasculitis associated with systemic diseases and 35% of patients with idiopathic retinal vasculitis had antiendothelial cell antibodies in comparison to 1% of the control. Antiendothelial cell antibodies have been described in several connective tissue disorders associated with systemic vasculitis. Significance of this association in retinal vasculitis is still not clear. Immunophenotyping of the inflammatory cellular infiltrate done in various retinal vasculitis and autoimmune uveitis indicate predominant involvement of T-cells [62][63][64][65 ] Further characterization of the T- cells have indicated that they are CD4 positive. The expression of MHC Class II antigen (HLA-DR) have been found in retinal pigment epithelial cells and vascular endothelial cells. [66 ] The predominant presence of T-cells in these eyes indicate that a cell-mediated immune mechanism is involved in the pathogenesis of these diseases. Light microscopic and immunohistochemical studies [67],[68] have demonstrated predominant T-cell involvement in the lymphocytic infiltration of epiretinal membrane (ERM) and subretinal membrane (SRM) of Eales' disease. Presence of predominant T-cells in the ERM and SRM of Eales' disease probably indicate that a cell­mediated immune mechanism might be playing a role in the proliferative phase of the disease with membrane formation on the surface of the retina.

Evidences of T-cell involvement in retinal vasculitis condition suggest that treatment should be directed to the down-regulation of the effects of the activated T-cells.

Certain experimental evidences suggest an autoimmune mechanism involved in retinal vasculitis. Stanford et a1 [69] have been able to produce an experimental retinal vasculitis in black hooded Lister rats by inoculating retinal S-antigen. Clinical, fluorescein angiographic, and histopathologic similarities have been observed between such experimental retinal vasculitis and human retinal vasculitis. Although predominant peripheral retinal involvement in Eales' disease was not seen in such experimental animals, the role of retinal autoimmunity in pathogenesis of Eales' disease should be considered.

C. Biochemical Studies in Eales' Disease

Several biochemical studies [71][72] have been done on the serum and vitreous samples of patients with Eales' disease [Table - 6]. Pratap et al [70] have found raised alpha-globulins and reduced albumin levels in the serum samples of patients with Eales' disease. Rengarajan et al [71] have identified a distinct protein spot at iso-electric point (pI) of 5.9 with a molecular weight around 23 KD in the serum of patients with Eales' disease by two-dimensional SDS-PAGE analysis and isoelectric focussing. The authors feel that these factors isolated from the serum could have angiogenic properties and play an important role in the pathogenesis of Eales' disease. Sen et a1 [72] have found raised serum alpha-1 acid glycoprotein (an important immunoregulatory protein formed by lymphocytes and epithelial cells) levels in 27 patients of Eales' disease with vasculitis. Various experimental studies, [73] both in vitro and in vivo, suggest that certain peptide growth factors, e.g. platelet-derived growth factor (PDGF), insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), transforming growth factors (TGF­a and TGF-(3) etc., play a key role in the process of neovascularization both by direct and indirect means. These have been demonstrated in several vascular retinopathies of the eye.


  VI. PATHOLOGY Top


The clinical manifestation of this disease is due to three basic pathologic changes: inflammation, ischaemia, and neovascularization and its sequelae. The site of involvement is predominantly the peripheral retina. Inflammation involves both the peripheral veins and arterioles, predominant involvement being the veins. Histopathologic studies of Eales' disease have conspicuously been few as the disease occurs in young healthy individuals. In most cases, pathologic studies have been done only in advanced cases with complications. [5],[25],[50],[51],[74],[75] All these studies have uniformly demonstrated infiltration of chronic inflammatory cells, especially lymphocytes. In addition, Stock [50] and Gilbert [51] have demonstrated acid-fast bacilli on the peripheral retinal lesion and perivascular sheath, respectively.

With the advent of vitreoretinal surgery, many cases of Eales' disease are subjected to vitrectomy for non-resolving vitreous haemorrhage and/or tractional retinal detachment. This allows obtaining intraocular tissue sample in the proliferative phase of the disease. In a study of 11 cases of Eales' disease with vitreous haemorrhage, Biswas et a1 [76] did not find any significant difference in the composition of the vitreous specimens from those with other vascular retinopathies. In another study by light microscopy and immunohistochemistry of 8 specimens of epiretinal membrane (ERM) in Eales' disease, the membranes were found composed of several neovascular channels with glial cells, macrophages , fibrocytes, retinal pigment epithelial cells with variable amount of collagen material and basement membrane. In comparison to other vascular retinopathies, ERM in Eales' disease contained significant lymphocytic infiltration. These lymphocytes were seen around the newly formed vascular channels and diffusely within the ERM itself [Figure - 13]. Subretinal membrane in Eales' disease also showed such lymphocytic infiltration, although vascular channels were not seen [Figure - 14].

Lymphocytic infiltration in the ERMs and SRMs of Eales' disease could be due to extension of the basic pathologic process from the retina into the membrane. Intact internal limiting membrane and the physical state of the vitreous gel is known to provide a barrier to the migration of cells from the retina. However, in response to various stimuli, migration of cells is known to occur on the surface or beneath the retina. A small break in the internal limiting membrane can occur due to ongoing inflammation in the active phase of the disease. Such damage can also occur in the retinal pigment epithelial barrier leading to migration of inflammatory cells, as well as other cells in the ERM and SRM. [77] The immunophenotyping of the lymphocytic infiltrates [68] in the ERM and SRM in Eales' disease were found to be predominantly of T- cell type [Figure - 15] with few B cells [Figure - 16]. Predominance of T-cells in the ERM and SRM indicate a cell-mediated immune reaction involved in the formation of these membranes.

Inflammation of or around the retinal vessels occurs in a host of ocular and systemic diseases [Table - 2].

Histopathologic study of the eyes in these diseases have demonstrated inflammation of the retinal vessel and lymphocytic infiltration of the vessel wall. Immunohistochemical studies of Behcet's disease 62 sarcoidosis[63] and pars planitis [64] have shown predominant involvement of T-cells. Factor(s) responsible for triggering lymphocytic infiltration in Eales' disease are not yet known. Although various authors have claimed aetiological association of tuberculoprotein, parasitic diseases etc., the same has not been clearly established [46],[62 ] The role of such factors in the initiation of T cell-mediated immune response needs to be investigated. The immunopathologic finding of predominance of T lymphocytes in the inflammatory infiltrate suggests that a therapeutic agent which preferentially suppresses T-cell function may be beneficial in the management of the active stage of this disease.


  VII. TREATMENT Top


The treatment of Eales' disease is symptomatic. It is aimed at reducing retinal perivasculitis and associated vitritis; at reducing the risks of vitreous haemorrhage from new vessels on the retina and/or the optic nerve head by retinal ablation and surgical removal of non-resolving vitreous haemorrhage and/ or vitreous membranes. Historically, Roentgen therapy [78],[79] and surface diathermy [80] have been tried and abandoned. The present-day modalities of treatment are confined to corticosteroids, photocoagulation with or without anterior retinal cryoablation (ARC), and vitrectomy at various stages of the disease process [Table - 7].

A. Corticosteroids

Corticosteroids form the mainstay of treatment for cases with active perivasculitis in Eales' disease. Oral and periocular steroids have been advocated for control of retinal vasculitis. Initially, high doses of oral steroids, e.g. prednisolone 2 mg/kg body wt, are given, gradually tapering off as the vasculitis begins to subside.

Periocular depot steroids (hydrocortisone or depo­medrol) are given as deep posterior sub-Tenon injection in active retinal vasculitis.

B. Antitubercular Treatment (AM)

Despite failure to demonstrate active pulmonary or extrapulmonary tuberculosis, the presence of an occasional old healed tuberculous lesion and a positive Mantoux test have led many to think that hypersensitivity to tuberculoproteins plays a role in the causation of this disease. Antitubercular treatment is given in Eales' disease empirically. The ATT regimen usually includes two drugs (rifampicin 450 mg; isoniazid 300 mg once daily) for a period of nine months. This ATT treatment protocol is usually reserved for cases with acute phlebitis with massive infilteration, nodule formation, and complete obliteration of segments of the vein.

C. Photocoagulation

Photocoagulation remains the mainstay of treatment modality in the proliferative stage of Eales' disease. Xenon arc photocoagulation was first used successfully by Meyer Schwickerath [81] to destroy the surface new vessels on the retina in Eales' disease and since then many others have reported beneficial effects 47.82 However, since Eales' disease affects mainly the peripheral retina, xenon arc photocoagulation has been found inadequate because of its inability to reach the periphery. Therefore a combined form of treatment involving xenon arc photocoagulation in the paracentral zone and anterior retinal cryopexy in the periphery has been tried by Das and Namperumalsamy. [17] In a prospective study involving 29 patients, vision was found stabilized or improved in 80% of the eyes. Xenon arc photocoagulation was done in the area posterior to the vortex vein and cryotherapy was done anterior to the vortex vein. Cryotherapy consisted of 4 to 5 ophthalmoscopically controlled transconjunctival applications in each quadrant involved by the disease and not more than two quadrants were treated in one cryositting.

In contrast to xenon photocoagulation, laser photocoagulation is more advantageous because of fewer complications and its ability to reach the retinal periphery using either slit-lamp or indirect ophthalmoscopic delivery system. Currently, it is the most accepted modality of treatment in Eales' retinopathy. However, doubts still persist regarding the stage of retinopathy most appropriate for photocoagulation, since vitreous haemorrhage occurs at any stage of Eales' disease. It is not known whether photocoagulation in the very early stage of retinopathy, i.e. the stage of the angiopathy, will prevent further development and progression of the disease. It is also not known whether panretinal photocoagulation involving all the 4 quadrants is necessary as in diabetic retinopathy or whether segmental scatter photocoagulation of the involved quadrants of the retina will suffice.

These questions were addressed in a prospective randomized clinical trial and the results of the study showed that photocoagulation was beneficial in stage II and III of Eales' disease." The study demonstrated that many of those with stage I Eales' retinopathy do not require photocoagulation while those with stage IV retinopathy are too advanced to benefit from such treatment.

Focal treatment of flat retinal new vessels, sectoral scatter photocoagulation of areas of capillary dropouts and direct treatment of neovascular frond into the vitreous have been found beneficial in proliferative Eales' retinopathy [84] [Figure - 5]b, [Figure - 10]a and b. Regression of retinal neovascularization and vitreous neovascular fronds have been observed in 89 and 80% of cases, respectively. But disc new vessels do not regress readily [84] meaning thereby that eyes with NVD need more vigorous treatment.

In general, only a moderate power is required for laser treatment in Eales' disease and panretinal photocoagulation is rarely necessary. There could be minor complications associated with laser photocoagulation. Retinal haemorrhages are noted in few cases but major bleeding is uncommon with proper selection of the intensity and other parameters necessary for photocoagulation. Occasionally, retinal gliosis laid down by regressing new vessels following photocoagulation undergoes further contraction and causes a variety of retinal complications that include macular distortion, retinal tear, and rhegmatogenous retinal detachment. To avoid these complications, a special technique of treatment, anchoring photocoagulation, has been advocated. [85] This consists of initial treatment around the posterior pole and neovascular lesion followed by scatter treatment of the area of capillary nonperfusion.

D. Anterior Retinal Cryoablation (ARC)

Anterior retinal cryotherapy has been successfully tried in eyes with vitreous haemorrhage caused by proliferative diabetic retinopathy [86][87][88][89][90] However, the incidence of tractional retinal detachment is reported to be high after primary ARC . [86]

Anterior retinal cryoablation was found useful inclearing vitreous haemorrhage in a mixed group of patients with proliferative diabetic retinopathy and Eales' disease (HKT, AK - unpublished data).

Clearing of vitreous blood was faster in eyes with recent onset haemorrhage and in non-diabetic patients. The technique of ARC consisted of 180° inferior conjunctival peritomy; isolation and bridling of the medial, inferior, and lateral recti muscles; and applications of 16 cryo spots (8 per quadrant in two rows) of 8 seconds each anterior to the equator under periocular anaesthesia [Figure - 17].

The exact mechanism of action of ARC is unclear, though it appears that ARC causes breakdown of blood-retinal barrier, which in turn leads to the clearance of liquefied blood via the chorio capillaries. Experimental studies have shown that following ARC there is an increased macrophage response and invasion into the vitreous cavity which engulf RBCs. ARC also directly ablates the peripheral retina and could destroy the ischaemic and neovascular areas in Eales' disease. While primary ARC is considered in small undilating pupil, and in hazy ocular media due to cataract, after cataract or residual vitreous haemorrhage, ARC is usually reserved as an adjunct to photocoagulation. [17]

E. Vitrectomy

Vitreous haemorrhage is the prime cause for impaired vision in Eales' disease. The first episode of vitreous haemorrhage usually clears but recurrent vitreous haemorrhages may lead to formation of traction bands and membranes in the vitreous and subsequent complications. However, the number of vitreous haemorrhages do not necessarily correlate with the changes that occur in the retina.

Despite the available therapeutic measures, vitreous haemorrhages are still common and occur quite often lead to destructive intraocular complications. Pars plana vitreous surgery as in any other proliferative retinopathies helps in restoration of vision by removing the unresolved blood and vitreous membranes.

The main indications for vitrectomy include unresolving vitreous haemorrhage, tractional retinal detachment involving the posterior pole, multiple vitreous membranes with or without tractional retinal detachment, and combined tractional and rhegmatogenous retinal detachment.

Vitrectomy in Eales' disease is found to be less risky than diabetic retinopathy because of early and complete posterior vitreous detachment, though retinitis proliferans is fairly common in long-standing cases.

The prognosis becomes unfavourable if posterior vitreous detachment is either incomplete or absent.

The surgical technique of pars plana vitrectomy in Eales' disease is fairly simple and only the central portion of the opaque vitreous is removed in most instances [Figure - 18]. A single dense vitreous membrane or multiple layers of membranes are encountered. Once this membrane is perforated by the vitreous probe and the retrohyaloid space is entered, the vitreous cavity becomes turbid invariably due to old blood coming from behind this membrane. At this stage, the vitreous cavity is irrigated by the infusion fluid and vitreous lavage is carried out till a clear view is obtained. If a central fibrovascular stalk is found coming from the disc, this is circumcised starting from the periphery. Active fresh bleeding is controlled by increasing the intraocular tension, by raising the bottle containing the infusion fluid or by using endodiathermy. It is better to avoid going to the peripheral retina and vitreous base in order to avoid injury to the retina or to the lens. [91][92][93]

In addition, lensectomy may be necessary. Intraoperative photocoagulation either by endophotocoagulator or with indirect ophthalmoscopic delivery system is done at conclusion of surgery.

The epiretinal membranes, when encountered, are peeled and removed. Segmentation and delamination of epiretinal membranes are less frequently necessary in vitrectomy in Eales' disease in contrast to diabetic retinopathy [Figure - 19]a and b.

The intraoperative complications, though rare, can occur such as bleeding from the retinal vessels, injury to the lens and accidental injury to the retina. The major postoperative complications are the recurrent vitreous haemorrhages, postoperative subcapsular cataract, rubeosis iridis, and neovascular glaucoma.

In a study of 281 cases in one centre, 4.62% eyes required lensectomy while scleral buckling was necessary in 8.54% of cases (PN-unpublished data). Following vitrectomy 70 to 80% of eyes had visual improvement (VA > 6/60) and 45% eyes had marked improvement (VA 6/12 to 6/6). In another study of 223 cases, combined vitrectomy and scleral buckling was required in 6 eyes (2.7%); lensectomy was required in 71 eyes (32%); retinotomy was required in 5 eyes (2%); and 7 eyes (3%) required silicone oil injection (PNN - unpublished data).

A direct relationship was found to exist between the episodes of vitreous haemorrhage and visual improvement following vitreous surgery [93] Visual improvement was better with fewer episodes and shorter duration of vitreous haemorrhage. Patients who had had photocoagulation prior to vitreous surgery enjoy better prognosis and show better visual improvement. [94][95][96]

The complications of surgery are very minimal. The poor results are generally due to the presence of long­standing disease process prior to vitreous haemorrhage. Hence, if vitreous haemorrhage does not resolve within three to four months, vitrectomy is usually advised.


  VIII. FUTURE DIRECTION OF RESEARCH Top


As the aetiopathogenesis of this vision-threatening retinal inflammatory disease still remains to be ascertained, a multidisciplinary and often a multicentre collaborative approach is needed to unravel the exact pathogenic mechanism(s). Following suggestions may be helpful for future research.

A well-designed clinical study to evaluate the various associations with Eales' disease, e.g. tuberculosis, tuberculoprotein, hypersensitivity, neurological disease, and auditory disturbances. The clinical study could also re-evaluate certain treatment modalities currently used, viz, ATT and oral/sub-Tenon steroids; and early versus deferred vitrectomy.

To study the various angiogenic and inflammatory mediators (interleukins, etc.) in the various stages of Eales' disease and to compare with other retinal vasculitis.

To develop an animal model of Eales' disease with tuberculoprotein or biochemically isolated specific protein from patients with Eales' disease.

Histopathologic, immunohistochemical study of eyes with Eales' disease (if obtained), so also vitreous, ERM and SRM obtained following vitrectomy, using specific lymphocyte markers, marker for immunoglobulin, major histocompatibility complexes and adhesion molecules etc., to identify the specific immunological mechanism involved in this disease[97].

 
  References Top

1.
Eales H. Retinal haemorrhages associated with epistaxis and constipation. Brim Med Rev. 9:262, 1980.  Back to cited text no. 1
    
2.
Eales H. Primary retinal haemorrahge in young men. Ophthalmic Rev. 1:41, 1882.  Back to cited text no. 2
    
3.
Wadsworth. Recurrent retinal haemorrhage followed by the development of blood vessels in the vitreous. Ophthalmic Rev. 6:289, 1887.  Back to cited text no. 3
    
4.
Elliot AJ. Recurrent intra ocular haemorrhage in young adults: Sales' disease. A preliminary report. Trans Cand Ophthalmol Soc. 46:39, 1948.  Back to cited text no. 4
    
5.
Kimura SJ, Carriker FR, Hogen MJ. Retinal vasculitis with intra ocular haemorrhage. Classification and results of special studies. Arch Ophthalmol. 56:361, 1956.  Back to cited text no. 5
    
6.
Keith-Lyle T, Wybark. Retinal vasculitis. Br J Ophthalmol. 45:778, 1961.  Back to cited text no. 6
    
7.
Cross AG. Vasculitis retinae. Trans Ophthalmol Soc UK. 83:133, 1963.  Back to cited text no. 7
    
8.
Puttamma ST. Varied fundus picture of central retinal vasculitis. Trans Asia Pacific Acad Ophthalmol. 3:520, 1970.  Back to cited text no. 8
    
9.
Duke-Elder S, Dobree JH. System of Ophthalmology. Vol.X. London. Henry Kimpton.  Back to cited text no. 9
    
10.
Murthy KR, Abraham C, Baig SM, et al. Sales' disease. Proc All Ind Ophthalmol Soc. 33:323, 1977.  Back to cited text no. 10
    
11.
Spitzans M, Meyer-Schwickerath GT, Stephen B. Clinical Picture of Sales' disease. Grafes Arch Clin Exp Ophthalmol. 194:73, 1975.  Back to cited text no. 11
    
12.
Elliot AJ. Thirty years observation of patients with Sales' disease. Am J Ophthalmol. 80:404, 1975.  Back to cited text no. 12
    
13.
Abraham C, Baig SM, Badrinath SS. Eales' disease. Proc All India Ophthalmol Soc. 33:226, 1977.  Back to cited text no. 13
    
14.
Malik SRK, Patnaik B. Fluorescein angiography in Eales' disease. Ind J Ophthalmol. 21:5, 1973.  Back to cited text no. 14
    
15.
Theodosisadis G. Fluorescein anigography in Eales' disease. Am J Ophthalmol. 69:271, 1970.  Back to cited text no. 15
    
16.
Charmis J. On the classification and management of the evolutionary course of Eales' disease. Trans Ophthalmol Soc UK. 85:157, 1965.  Back to cited text no. 16
    
17.
Das TP, Namperumalsamy P. Combined photocoagulation and cryotherapy in treatment of Eales' retinopathy. Proc All Ind Ophthalmol Soc. 45:108, 1987.  Back to cited text no. 17
    
18.
Kalsi R, Patnaik B. The developing features of phlebitis retinae (A vertical study) Ind J Ophthalmol. 27:87, 1979.  Back to cited text no. 18
    
19.
Ashton N. Pathogenesis and aetiology of Eales' disease. Acta XIX Concilium Ophthalmologicum 2: 1962.  Back to cited text no. 19
    
20.
Bonnet P. Recurrent haemorrhage of the vitreous (Eales' disease) and genital tuberculosis. Bull Soc Ophthalmol Fr. 7:776, 1951.  Back to cited text no. 20
    
21.
Finnoff WC. Some impressions derived from the study of recurrent haemorrhages into the retina and vitreous of young persons. Trans Am Ophthalmol Soc 19:238, 1921.  Back to cited text no. 21
    
22.
Gupta SP. Eales' disease - its aetiology, pathology and treatment. Acta XVIII Concilium Ophthalmologicum, 2:1325-1329, 1960.  Back to cited text no. 22
    
23.
Wagner HP. Some recent studies on Eales' disease. Am Med Sci. 236:250, 1958.  Back to cited text no. 23
    
24.
Verhoeff FH, Simpson GV. Tubercle within central retinal vein. Haemorrhagic glaucoma; periphlebitis retinalis in the other eye. Arch Ophthalmol. 24:645, 1940.  Back to cited text no. 24
    
25.
Elliot AJ. Recurrent intraocular haemorrhage in young adults (Eales' disease). A report of 31 cases. Trans Am Ophthalmol Soc. 52:811, 1954.  Back to cited text no. 25
    
26.
Donders PC. Eales' disease. Doc Ophthalmol. 12:1-105, 1958.  Back to cited text no. 26
    
27.
Marchesani O. Retinal periphlebitis as ocular manifestation of thromboangitis obliternas. Arch Augeuh 109:124-138, 1935.  Back to cited text no. 27
    
28.
Benedit WL, Wagner P. Thromoangitis obliterans of the retinal vessels. Am J Med Sci. 199:296, 1940.  Back to cited text no. 28
    
29.
Wagner HP. Some recent studies on Eales' disease. Am J Med Sci. 236:250, 1958.  Back to cited text no. 29
    
30.
Schmid AE. Relation of retinal periphlebitis and recurrent juvenile haemorrhages of vitreous humor to endangitis obliterans of Winiwater-Buerger. Ophthalmologica. 110:259, 1945.  Back to cited text no. 30
    
31.
Fielo EJ, Foster JB. Periphlebitis retina and multiple sclerosis. J Neurol Neurosurg Psychiat. 25:269, 1962.  Back to cited text no. 31
    
32.
Opala G, Wajgt A, Ochud OS, et al. Eales' disease and multiple sclerosis. Case report. (Pol). Neurologia I Neurochirurgia Polska. 22:340-342, 1988.  Back to cited text no. 32
    
33.
Singhal BS, Dastur DK. Eales' disease with neurological involvement. Part I. Clinical Features in 9 patients. J Neurol Sci. 27:313-321, 1976.  Back to cited text no. 33
    
34.
Masson C, Denis P, Prier S, et al. Eales' disease with neurologic disorders. Fre Revue Neulogique. 144:817­819, 1988.  Back to cited text no. 34
    
35.
Gordon MF, Coyle PK, Golub B. Eales' disease presenting as stroke in the young adult. Annals Neurol. 24:264-266, 1988.  Back to cited text no. 35
    
36.
Puttanna ST. Retinal vasculitis and focal sepsis. Proc All Ind Ophthalmol Soc. 21:108, 1964.  Back to cited text no. 36
    
37.
Kahan AN, Kahan IL, Benko R. Acquired acanthocytosis and myopathies in a case of Eales' disease. Br J Ophthalmol 47:632, 1963.  Back to cited text no. 37
    
38.
Rahi AH, Nath K, Gogi R. Acanthocytosis in Eales' disease. Orient Arch Ophthalmol. 7:269, 1969.  Back to cited text no. 38
    
39.
Jain IS, Kanwar GS, Das KG. Study of red cell morphology and abnormal haemoglobin in the causation of Eales' disease and other vitreous haemorrhage. Ind J Ophthalmol. 18:111, 1970.  Back to cited text no. 39
    
40.
Bertrams B, Wolf S, Hof A, et al. Rehologic findings in patients with Eales' disease (Ger). Klin Monatsblatter Fur Augenheilkund. 195:254-256, 1989.  Back to cited text no. 40
    
41.
Bryselbout E, Turut P, Malthieu D, et al. Eales' syndrome and hypereosinophilia. Bulletin De Societies De Ophthalmologie De France. 89:1421-1424, 1989.  Back to cited text no. 41
    
42.
Vanacore, Maselli E. Blood coagulation anomaly in a case of Eales' disease. (Corrector effect of corticosteriod treatment). Ann Ottamol Clin Ocul. 91:1132-1140, 1965.  Back to cited text no. 42
    
43.
Boase DL, Gale RE, Huehns ER. Oxygen dissociation curve in Eales' disease. Br J Ophthalmol. 64:745, 1980.  Back to cited text no. 43
    
44.
Pathak SD, Mehra KS, Dube B. Blood fibrinolytic studies in Eales' disease. Ind J Ophthalmol. 25:5-8, 1977.  Back to cited text no. 44
    
45.
Pathak SD, Mehra KS, Dube B. Blood fibrinolysis in Eales' disease ( a follow up study). Ind J Ophthalmol. 25:9-11, 1977.  Back to cited text no. 45
    
46.
Renie WA, Murphy RP, Anderson KC, et al. The evaluation of patients with Eales' disease. Retina 3:243­248, 1983.  Back to cited text no. 46
    
47.
a.Gieser SC, Thomas R, Sen S, et al. Risk factors of Eales' disease in South India. Invest Ophthalmol Vis Sci. 34 (suppl):1296, 1993.  Back to cited text no. 47
    
48.
Pahwa JM, Garg MP, Samuel A, et al. Eales' disease and the treatment by photocoagulation (with a review of nearly 200 cases). Acta XXI Concilium Ophthalmologicum 832, 1970.  Back to cited text no. 48
    
49.
Wania JH. In panel discussion of Eales' disease. Proc X Cong Asia - pacific Acad Ophthalmol. 130, 1985.  Back to cited text no. 49
    
50.
Patney HL, Garg MP. Aetiological study of Eales' disease. J Ind Med Assoc. 44:650, 1965.  Back to cited text no. 50
    
51.
Stock W. Retinal haemorrhage due to miliary tuberculosis. Klin Monatsol Augenh. 99:367-372, 1937.  Back to cited text no. 51
    
52.
Gilbert TW. Periphlebitis and endovasculitis of retinal vessels. Klin Monatsbl Augenh. 94:335-349, 1935.  Back to cited text no. 52
    
53.
Finoof WC. Ocular tuberculosis, Experimental and clinical. Arch Ophthalmol. 53:130-136, 1924.  Back to cited text no. 53
    
54.
Awasthi P, Mehrotra ML, Srivastava SN. Ocular conditions in pulmonary tuberculosis patients in India. Acta XX Concilium Ophthalmologicum. 1025, 1966.  Back to cited text no. 54
    
55.
Muthukkaruppan VR, Rengarajan K, Chakkalath HR, et al. Immunological status of patients of Eales' disease. Ind J Med Res. 90:351-359, 1989.  Back to cited text no. 55
    
56.
Raj N, Krishnamurthy MS, Anantharaman DS. Prevalence of non-specific sensitivity in some parts of India. Ind J Med Res 63:1098, 1975.  Back to cited text no. 56
    
57.
Koliopoulos JX, Perkins ES, Seitanides BE. Serum immunoglobulins in retinal vasculitis. Br J Ophthalmol 54:233-236, 1970.  Back to cited text no. 57
    
58.
Johnson GJ, Bloch KH. Immunoglobulin levels in retinal vascular abnormalities and pseudoxanthoma elasticum. Arch Ophthalmol. 81:322-324, 1969.  Back to cited text no. 58
    
59.
Andrew BS, McIntosh J, Petts V, et al. Circulating immune complex in retinal vasculitis. Clin Exp Immunol. 29:23-29, 1977.  Back to cited text no. 59
    
60.
Bertrams J, Spitznas M, Rommelfanger M. Missing evidence for HLA antigen association with Eales' disease, chorioretinitis, central serous retinopathy and malignant choroidal melanoma. Invest Ophthalmol Vis Sci. 17:918-920, 1978.  Back to cited text no. 60
    
61.
Kasp E, Graham EM, Stanfold MR, et al. A point prevalence study of 150 patients with idiopathic retinal vasculitis - Clinical relevance of antiretinal autoimmunity and circulating immune complexes. Br J Ophthalmol. 73:722-730, 1989.  Back to cited text no. 61
    
62.
Edelstan C, Cruz DD, Hughes GRV, et al. Antiendothelial cell antibodies in retinal vasculitis. Curr Eye Res. 11: 203-208, 1992.  Back to cited text no. 62
    
63.
Charteris DG, Champ C, Rosenthal AR, et al. Behcet's disease - Activated T lymphocytes in retinal perivasculitis. Br J Ophthalmol. 76:499-501, 1992.  Back to cited text no. 63
    
64.
Chan C-C, Wetzig RP, Palestine AG, et al. Immunopathology of ocular sarcoidosis. Arch Ophthalmol. 105:1398-1402, 1987.  Back to cited text no. 64
    
65.
Wetzig RP, Chan C-C, Nussenblatt RB, et al. Clinical and immunopathological studies of pars planitis in a family. Br J Ophthalmol. 72:5-10, 1988.  Back to cited text no. 65
    
66.
Chan C-C, Palestine AG, Kuwabara T, et al. Immunopathological study of Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 105:607-611, 1988.  Back to cited text no. 66
    
67.
Chan C-C, Detrick B, Nussenblatt RB, et al. HLA-DR antigens on retinal pigment epithelial cells from patients with uveitis. Arch Ophthalmol. 104:725-729, 1986.  Back to cited text no. 67
    
68.
Biswas J, Rao NA. Epiretinal membrane in Eales' disease and other vascular retinopathies. Invest Ophthalmol Vis Sci. 31 (Suppl):369, 1990.  Back to cited text no. 68
    
69.
Badrinath SS, Biswas J, Sharma T, et al. Immunophenotyping of inflammatory infiltrates in epiretinal (ERM) and subretinal membrane (SRM) in Eales' disease. Invest Ophthalmol Vis Sci. 33 (Suppl):857, 1992.  Back to cited text no. 69
    
70.
Stanford MR, Graham EM, Kasp E, et al. Retinal vasculitis - correlation of animal and human disease. Eye. 1:69-77, 1987.  Back to cited text no. 70
    
71.
Pratap VB, Mehra MK, Gupta RK. Electrophoretic pattern of serum proteins in Eales' disease. Ind J Ophthalmol. 23:14-16, 1976.  Back to cited text no. 71
    
72.
Rengarajan K, Muthukkaruppan VR, Namperumalsamy P. Biochemical analysis of serum proteins from Eales' patients. Curr Eye Res. 8:1259-1269, 1989.  Back to cited text no. 72
    
73.
Sen DK, Sarin GS, Mathur MD, et al. Serum alpha-1 acid glycoprotein levels in patients with idiopathic peripheral retinal periphlebitis. 48th All Ind Ophthalmol Soc Meeting (abstract) pp. 21, 1990.  Back to cited text no. 73
    
74.
Schultz AS, Grant MB. Neovascular growth factors. Eye. 5: 170-180, 1991.  Back to cited text no. 74
    
75.
Ballantyne AJ, Michaelson IC. A case of perivasculitis retinae associated with symptoms of cerebral disease. Br J Ophthalmol. 21:22-35, 1937.  Back to cited text no. 75
    
76.
Kono T, Yamana Y, Kurimoto S, et al. Histopathology of Eales' disease - retinal vascular changes and proliferation of preretinal membranes. Acta Soc Ophthalmol Jpn. 89:1001-1010, 1985.  Back to cited text no. 76
    
77.
Biswas J, Badrinath SS, Subramanyam CSV, et al. Microscopic study of vitreous aspirate - A preliminary study. Trans X Asia - Pacific Acad Ophthalmol. 664, 1985.  Back to cited text no. 77
    
78.
Gilbert C, Hiscott P, Unger W, et al. Inflammation and the formation of epiretinal membranes. Eye 2 (Suppl): 5140-5156, 1988.  Back to cited text no. 78
    
79.
Guyton JS, Reese AB. The use of roentgen therapy for clinical diseases characterised by new formed vessels (Eales' disease). A preliminary report. Arch Ophthalmol. 40:489, 1948.  Back to cited text no. 79
    
80.
Reese AB, Jones IS. Treatment of Eales' disease by ro entgen therapy. Am J Ophthalmol. 49:1311, 1960.  Back to cited text no. 80
    
81.
Franceschetti A. Trans scleral diathermic coagulation in Eales' disease. Acta Concillum Ophthalmolgicum. 19:859, 1962.  Back to cited text no. 81
    
82.
Meyer-Schwickerath G. Eales' disease. Treatment with light coagulation. Acta Concillum Ophthalmologicum. 19:862, 1962.  Back to cited text no. 82
    
83.
Dayton GO Jr, Straatsma BR. Eales' disease and photocoagulation. Trans Pac Coast ophthalmol Soc. 43:12 129, 1962.  Back to cited text no. 83
    
84.
Das TP, Namperumalsamy P. Photocoagulation in Eales' disease. Results of prospective randomised clinical study. Presented in XXVI Int Cong Ophthalmol, Singapore. 1990.  Back to cited text no. 84
    
85.
Gopal L, Abraham C. Efficacy of photocoagulation in Eales' disease. Trans Asia-pacific Acad Ophthalmol. 10:689, 1985.  Back to cited text no. 85
    
86.
Patnaik B, Kalsi R. Understanding and management of Eales' disease. Acta XXV Concilium Ophthalogicum. pp. 2200, 1987.  Back to cited text no. 86
    
87.
Oesterhuis JA, Bijliner-Gorter H. Cryotreatment in proliferative diabetic retinopathy. Ophthalmologica. 181: 81, 1980.  Back to cited text no. 87
    
88.
Patnaik B, Kalsi R, Chary P. Cryopexy in the management of diabetic retinopathy. Preliminary report. Proc All Ind Ophthalmol Soc. 39:197, 1980.  Back to cited text no. 88
    
89.
Mosier MA, Dei Piero E, Gheewala SM. Anterio retinal cryotherapy in diabetic vitreous haemorrhage. Am J Ophthalmol. 100:440, 1985.  Back to cited text no. 89
    
90.
Benedict R, Olk RJ, Arribas NP, et al. Transconjunctival anterior retinal cryotherapy for proliferative diabetic retinopathy. Ophthalmology. 94: 612, 1987.  Back to cited text no. 90
    
91.
Ross WH, Goofner MJ. Peripheral retinal Cryopexy for subtotal vitreous haemorrhage. Am J Ophthalmol. 105:377, 1988.  Back to cited text no. 91
    
92.
Namperumalsamy P. Vitrectomy in Eales' disease. Trans Asia-Pacific Acad. Ophthalmol. 9:457, 1983.  Back to cited text no. 92
    
93.
Namperumalsamy P. Recent concepts on aetiology and management of Eales' disease. (P. Sivareddy Oration) Proc All Ind Ophthalmol Soc. 44:1986.  Back to cited text no. 93
    
94.
Namperumalsamy P, Kelkar AR, Das TP. Vitreous surgery in Eales' disease - When and Why. Presented in XXVI Ophthalmol. Singapore 1990.  Back to cited text no. 94
    
95.
Triester G, Machemer R. Results of vitrectomy of rare proliferative and haemorrhagic disorders. Am J Ophthalmol. 84:394, 1977  Back to cited text no. 95
    
96.
Michaels RG. Vitreous surgery. The C V Mosby & Co., pp. 236, 1981.  Back to cited text no. 96
    
97.
Badrinath SS, Honnatti MR. Vitrectomy in Eales' disease. Acta Int Cong Ophthalmol. 24:536, 1982.  Back to cited text no. 97
    


    Figures

  [Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4], [Figure - 5], [Figure - 6], [Figure - 7], [Figure - 8], [Figure - 9], [Figure - 10], [Figure - 11], [Figure - 12], [Figure - 13], [Figure - 14], [Figure - 15], [Figure - 16], [Figure - 17], [Figure - 18], [Figure - 19]
 
 
    Tables

  [Table - 1], [Table - 2], [Table - 3], [Table - 4], [Table - 5], [Table - 6], [Table - 7]


This article has been cited by
1 Eales disease 10 years experience with a rare disease | [Morbus Eales 10 Jahre Erfahrung mit einem seltenen Krankheitsbild]
Stoffelns, B.M., Kramann, C., Schoepfer, K.
Klinische Monatsblatter fur Augenheilkunde. 2009; 226(4): 299-304
[Pubmed]
2 Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease
Angayarkanni, N., Selvi, R., Pukhraj, R., Biswas, J., Bhavesh, S.J., Tombran-Tink, J.
Journal of Ocular Biology, Diseases, and Informatics. 2009; 2(1): 20-28
[Pubmed]
3 Correspondence
Querques, G., Noci, N.D.
Retina. 2009; 29(1): 121-123
[Pubmed]
4 Bevacizumab (Avastin) for the Treatment of Ocular Disease
Gunther, J.B., Altaweel, M.M.
Survey of Ophthalmology. 2009; 54(3): 372-400
[Pubmed]
5 Surgical outcomes for vitrectomy in Ealesæ disease
Shukla, D., Kanungo, S., Prasad, N.M., Kim, R.
Eye. 2008; 22(7): 900-904
[Pubmed]
6 Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and ealesæ disease
Murugeswari, P., Shukla, D., Rajendran, A., Kim, R., Namperumalsamy, P., Muthukkaruppan, V.
Retina. 2008; 28(6): 817-824
[Pubmed]
7 Eales disease and current therapies
Gong, Y., Wei, S.-H.
International Journal of Ophthalmology. 2008; 8(2): 369-371
[Pubmed]
8 Intravitreal steroids may facilitate treatment of Ealesæ disease (idiopathic retinal vasculitis): An interventional case series
Ishaq, M., Feroze, A.H., Shahid, M., Baig, M.A., Ameen, S.S., Feroze, S.H., Chishti, R.A.
Eye. 2007; 21(11): 1403-1405
[Pubmed]
9 New classification system-based visual outcome in Ealesæ disease
Saxena, S., Kumar, D.
Indian Journal of Ophthalmology. 2007; 55(4): 267-269
[Pubmed]
10 Association of mycobacteria with Ealesæ disease
Therese, K.L., Deepa, P., Therese, J., Bagyalakshmi, R., Biswas, J., Madhavan, H.N.
Indian Journal of Medical Research. 2007; 126(1): 56-62
[Pubmed]
11 Ealesæ disease: Oxidant stress and weak antioxidant defence
Ramakrishnan, S., Rajesh, M., Sulochana, K.
Indian Journal of Ophthalmology. 2007; 55(2): 95-102
[Pubmed]
12 Rapid regression of disc and retinal neovascularization in a case of Eales disease after intravitreal bevacizumab [3]
Kumar, A., Sinha, S.
Canadian Journal of Ophthalmology. 2007; 42(2): 335-336
[Pubmed]
13 Intravitreal steroids and Ealesæ disease
Shahid, M., Feroze, A.H., Ishaq, M., Baig, M.A., Feroze, S.H.
Journal of the Pakistan Medical Association. 2007; 57(4): 208-209
[Pubmed]
14 Eales disease
Ferrer, E., Moral, Ma.À.
Drugs of the Future. 2007; 32(5): 463-467
[Pubmed]
15 Association of retinal vasculitis (Ealesæ disease) and Meniere-like vestibulocochlear symptoms
Wagner, W., Fehrmann, A.
European Archives of Oto-Rhino-Laryngology. 2006; 263(2): 100-104
[Pubmed]
16 A comparative study of epiretinal membranes associated with Ealesæ disease: A clinicopathologic evaluation
Majji, A.B., Vemuganti, G.K., Shah, V.A., Singh, S., Das, T., Jalali, S.
Eye. 2006; 20(1): 46-54
[Pubmed]
17 Decreased platelet membrane fluidity in retinal periphlebitis in Ealesæ disease
Saxena, S., Srivastava, P., Kumar, D., Khanna, V.K., Seth, P.K.
Ocular Immunology and Inflammation. 2006; 14(2): 113-116
[Pubmed]
18 Epidemiology study of Eales disease and its risk factors in healthy young men
Xiao, J., Wei, S.-H., Wang, J., He, Y.
Journal of Jilin University Medicine Edition. 2006; 32(1): 157-159
[Pubmed]
19 Role of antitubercular therapy in Ealesæ disease
Sharma, Y.R., Krishna, K.R., Tewari, H.K., Rattan, A., Singh, D.V.
JK Science. 2005; 7(4): 208-211
[Pubmed]
20 The topographic distribution of retinal neovascularization in Ealesæ disease
Saxena, S., Kumar, D.
Annals of Ophthalmology. 2005; 37(4): 273-275
[Pubmed]
21 A new staging system for idiopathic retinal periphlebitis
Saxena, S., Kumar, D.
European Journal of Ophthalmology. 2004; 14(3): 236-239
[Pubmed]
22 Iron chelation abrogates excessive formation of hydroxyl radicals and lipid peroxidation products in monocytes of patients with Ealesæ disease: Direct evidence using electron spin resonance spectroscopy
Rajesh, M., Sulochana, K.N., Ramakrishnan, S., Biswas, J., Manoharan, P.T.
Current Eye Research. 2004; 28(6): 339-407
[Pubmed]
23 A case of juvenile vitreous hemorrhage presumably due to vitreoretinal adhesion
Uehara, J., Takeda, N., Uemura, A., Yashiro, S., Kitahashi, M., Kogahara, M.
Japanese Journal of Clinical Ophthalmology. 2004; 58(10): 1965-1968
[Pubmed]
24 Management of vitreous haemorrhage
Saxena, S., Jalali, S., Verma, L., Pathengay, A.
Indian Journal of Ophthalmology. 2003; 51(2): 186-196
[Pubmed]
25 Retinal neovascularization in Eales disease
Saxena, S., Kumar, D., Maitreya, A., Srivastava, P., Khanna, V.K., Nath, R., Seth, P.K.
Annals of Ophthalmology. 2003; 35(1): 25-27
[Pubmed]
26 Presence of a 88 kDa Eales protein in uveitis, tuberculosis, leprosy and rheumatoid arthritis
Rajesh, M., Sulochana, K.N., Sundaram, A.L., Krishnakumar, S., Biswas, J., Ramakrishnan, S.
Medical Science Monitor. 2003; 9(2): CR95-CR99
[Pubmed]
27 Full panretinal photocoagulation and early vitrectomy improve prognosis of retinal vasculitis associated with tuberculoprotein hypersensitivity (Ealesæ disease)
Abu EI-Asrar, A.M., Al-Kharashi, S.A.
British Journal of Ophthalmology. 2002; 86(11): 1248-1251
[Pubmed]
28 A long-term follow-up of Ealesæ disease
Atmaca, L.S., Batioglu, F., Atmaca Sonmez, P.
Ocular Immunology and Inflammation. 2002; 10(3): 213-221
[Pubmed]
29 Eales disease - An update
Biswas, J., Sharma, T., Gopal, L., Madhavan, H.N., Sulochana, K.N., Ramakrishnan, S.
Survey of Ophthalmology. 2002; 47(3): 197-214
[Pubmed]
30 Further investigations on the association of Mycobacterium tuberculosis with Ealesæ disease
Madhavan, H.N., Therese, K.L., Doraiswamy, K.
Indian Journal of Ophthalmology. 2002; 50(1): 35-39
[Pubmed]
31 Cytological study on vitreous extracts in Eales disease
Juan, L., Maonian, Z.
Chinese Ophthalmic Research. 2001; 19(3): 217-219
[Pubmed]
32 Purification and characterization of a novel 88 kDa protein from serum and vitreous of patients with Ealesæ disease
Sulochana, K.N., Rajesh, M., Ramakrishnan, S.
Experimental Eye Research. 2001; 73(4): 547-555
[Pubmed]
33 Presumed ealesæ disease with neurologic involvement: Report of three cases
Biswas, J., Raghavendran, R., Pinakin, G., Arjundas, D.
Retina. 2001; 21(2): 141-145
[Pubmed]
34 Polymerase chain reaction for detection of Mycobacterium tuberculosis in epiretinal membrane in Ealesæ disease
Madhavan, H.N., Therese, K.L., Gunisha, P., Jayanthi, U., Biswas, J.
Investigative Ophthalmology and Visual Science. 2000; 41(3): 822-825
[Pubmed]
35 Diagnostic and therapeutic approach to patients with retinal vasculitis
Stanford, M.R., Verity, D.H.
International Ophthalmology Clinics. 2000; 40(2): 69-83
[Pubmed]
36 Ocular neovascularization in patients with uveitis
Kuo, I.C., Cunningham Jr., E.T.
International Ophthalmology Clinics. 2000; 40(2): 111-126
[Pubmed]
37 Raised platelet thiobarbituric acid-reacting substances in proliferative Ealesæ disease
Srivastava, P., Saxena, S., Khanna, V.K., Kumar, D., Nath, R., Seth, P.K.
Indian Journal of Ophthalmology. 2000; 48(4): 307-309
[Pubmed]
38 Macular involvement Eales disease
Saxena, S., Kumar, D.
Annals of Ophthalmology - Glaucoma. 2000; 32(2): 98-100
[Pubmed]
39 Retinal vasculitis
Levy-Clarke, G.A., Nussenblatt, R.
International Ophthalmology Clinics. 200; 45(2): 99-113
[Pubmed]
40 Vitreoschisis in Ealesæ disease: Pathogenic role and significance in surgery
Badrinath, S.S., Gopal, L., Sharma, T., Parikh, S., Shanmugam, M.P., Bhende, P., Biswas, J.
Retina. 1999; 19(1): 51-54
[Pubmed]
41 Visual outcome in ealesæ disease with branch retinal vein occlusion
Saxena, S., Kumar, D.
Annals of Ophthalmology - Glaucoma. 1999; 31(3): 173-175
[Pubmed]
42 A 32-year-old man with vitreous hemorrhage and mediastinal lymphadenopathy
Scully, R.E., Mark, E.J., McNeely, W.F., Ebeling, S.H., Phillips, L.D.
New England Journal of Medicine. 1998; 338(5): 313-319
[Pubmed]
43 Profiling of human leukocyte antigens in Ealesæ disease
Biswas, J., Mukesh, B.N., Narain, S., Roy, S., Madhavan, H.N.
International Ophthalmology. 1997; 21(5): 227-281
[Pubmed]
44 Ealesæ disease: Accumulation of reactive oxygen intermediates and lipid peroxides and decrease of antioxidants causing inflammation, neovascularization and retinal damage
Bhooma, V., Sulochana, K.N., Biswas, J., Ramakrishnan, S.
Current Eye Research. 1997; 16(2): 91-95
[Pubmed]
45 Noninfectious posterior uveitis
Walker, J.D., Mitchel Opremcak, E.
Seminars in Ophthalmology. 1996; 11(1): 38-56
[Pubmed]
46 Stroke - A rare presentation of Ealesæ disease: A case report
Misra, U.K., Jha, S., Kalita, J., Sharma, K.
Angiology. 1996; 47(1): 73-76
[Pubmed]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
I. INTRODUCTION
II. PATIENT PROFILE
III. CLINICAL PI...
IV. NATURAL COURSE
V. AETIOPATHOGENESIS
VI. PATHOLOGY
VII. TREATMENT
VIII. FUTURE DIR...
References
Article Figures
Article Tables

 Article Access Statistics
    Viewed15675    
    Printed463    
    Emailed52    
    PDF Downloaded0    
    Comments [Add]    
    Cited by others 46    

Recommend this journal