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ORIGINAL ARTICLE
Year : 1996  |  Volume : 44  |  Issue : 2  |  Page : 87-89

A comparative evaluation of pilocarpine 1% and clonidine 0.125% versus timolol 0.5%


Dr. Rajendra Prasad Centre for Ophthalmic Sciences, A.I.I.M.S. New Dehi, India

Correspondence Address:
R Sihota
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, A.I.I.M.S. New Dehi
India
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Source of Support: None, Conflict of Interest: None


PMID: 8916595

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All the presently available antiglaucoma medications have either local or systemic adverse effects. Combinations of drugs are being used not only to increase the effectivity and compliance but also to decrease the incidence and magnitude of side effects. The single dose response of open angle glaucoma eyes to pilocarpine 1%, clonidine 0.125%, a combination of pilocarpine 1% and clonidine 0.125%, and timolol 0.5% was studied in a double blind, masked, cross over study. Over a period of twelve hours the effectivity of the combination of pilocarpine 1% and clonidine 0.125% was significantly more than that of either drug alone and was found to be similar to that of timolol 0.5%. No local or systemic adverse effects were seen.


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