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ORIGINAL ARTICLE
Year : 1996  |  Volume : 44  |  Issue : 3  |  Page : 157-160

Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas


Maulana Azad Medical College and Guru Nanak eye Centre, New Delhi, India

Correspondence Address:
P A Lamba
Guru Nanak Eye Centre, Maharaja Ranjit Singh Marg, New Delhi 110002
India
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Source of Support: None, Conflict of Interest: None


PMID: 9018993

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Thirty three eyes of 33 patients were prospectively evaluated to study the short term efficacy, safety, and overall surgical outcome of initial trabeculectomy for primary glaucomas with adjunctive intraoperative on postoperative 5-Fluorouracil (5-FU) use. Twelve eyes served as control who underwent trabeculectomy without adjunctive antimetabolites. Eleven eyes received intraoperative 5-FU, while 10 eyes received subconjunctival 5-FU postoperatively. Intraocular pressure (IOP) was maintained below 22 mmHg at 3 months of follow up in 90.9% and 80% of patients in the intraoperative and postoperative 5-FU groups respectively, without use of additional antiglaucoma medications, whereas 66.7% of the patients in the control group achieved similar IOP levels. Hypotony (I.O.P.<6mmHg) was seen more commonly after intraoperative 5-FU (27.3%). Corneal epithelial defects were seen exclusively in the postoperative 5-FU group (40%). The use of intraoperative 5-FU exclusively as a mode of antimetabolite delivery seems an acceptable alternative to enhance success rates of trabeculectomy for the primary glaucomas.


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