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ORIGINAL ARTICLE
Year : 2001  |  Volume : 49  |  Issue : 2  |  Page : 81-90

Role of Cytokines in experimental and clinical uveitis


Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

Correspondence Address:
Vijay K Singh
Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

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Source of Support: None, Conflict of Interest: None


PMID: 15884511

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Uveitis is a major cause of visual impairment. Experimental autoimmune uveitis mimics the clinical conditions of posterior uveitis in many ways. T-cells (particularly CD4[+] helper-T-cells) have been shown to play an important role in pathogenesis of experimental and clinical uveitis. Based on the pattern of cytokine they secrete, CD4[+] helper cells have been divided into Thl and Th2 subsets. Various Thl and Th2 cytokines appear to be involved in the pathogenesis and/or recovery from uveitis. This article discusses in detail the uveitopathogenic and therapeutic potential of Thl and Th2 cytokines in experimental and clinical uveitis.


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