ORIGINAL ARTICLE |
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Year : 2001 | Volume
: 49
| Issue : 2 | Page : 81-90 |
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Role of Cytokines in experimental and clinical uveitis
Vijay K Singh, Geeta Rai, Shyam S Agarwal
Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Correspondence Address:
Vijay K Singh Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Source of Support: None, Conflict of Interest: None | Check |
PMID: 15884511
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Uveitis is a major cause of visual impairment. Experimental autoimmune uveitis mimics the clinical conditions of posterior uveitis in many ways. T-cells (particularly CD4[+] helper-T-cells) have been shown to play an important role in pathogenesis of experimental and clinical uveitis. Based on the pattern of cytokine they secrete, CD4[+] helper cells have been divided into Thl and Th2 subsets. Various Thl and Th2 cytokines appear to be involved in the pathogenesis and/or recovery from uveitis. This article discusses in detail the uveitopathogenic and therapeutic potential of Thl and Th2 cytokines in experimental and clinical uveitis.
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