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ORIGINAL ARTICLE
Year : 2001  |  Volume : 49  |  Issue : 3  |  Page : 173-176

Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study


1 MBBS. Regional Institute of Ophthalmology, Medical College, Calcutta, India
2 MS. Regional Institute of Ophthalmology, Medical College, Calcutta, India
3 MD. Regional Institute of Ophthalmology, Medical College, Calcutta, India
4 MD,MNAMS,FRCS. Regional Institute of Ophthalmology, Medical College, Calcutta, India

Correspondence Address:
Pankaj K. Agarwal
MBBS. Regional Institute of Ophthalmology, Medical College, Calcutta, India

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Source of Support: None, Conflict of Interest: None


PMID: 15887725

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Purpose: To evaluate the efficacy of topical (1%) and systemic itraconazole against common fungi such as Aspergillus and other filamentous fungi that cause mycotic corneal ulcer. Methods: A prospective randomised, controlled study was done in 54 clinically suspected cases of fungal keratitis of which 44 were culture proven. Half the cases (n=27) with superficial involvement were treated with only topical itraconazole (1%) and the other half were treated with both topical and systemic itraconazole. Results:Aspergillus, Penicillium and Fusarium were the most common fungi isolated. The ulcer resolved in 42 eyes (77%) and 12 eyes (23%) did not respond well to treatment. Four of 12 non-responding eyes were caused by Fusarium species. Conclusion: Itraconazole, given either topically or systemically, is effective in treating mycotic corneal ulcers.


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