| ORIGINAL ARTICLE
|Year : 2003 | Volume
| Issue : 1 | Page : 39-44
Role of prophylactic intravitreal antibiotics in open globe injuries.
S Narang, V Gupta, A Gupta, Mangat R Dogra, Surinder S Pandav, S Das
Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Purpose: To determine the efficacy of prophylactic intravitreal antibiotics in reducing the incidence of endophthalmitis after trauma.
Methods: This was a prospective, randomised, case control study of 70 consecutive patients with open globe injury. The patients were prospectively randomised into group I (32 eyes) and group II (38 eyes). Group I patients were given prophylactic intravitreal injection of vancomycin 1 mg and ceftazidime 2.25 mg at the conclusion of primary repair. Group II patients were not given prophylactic intravitreal antibiotics. All the patients received intravenous ciprofloxacin.
Results: The incidence of endophthalmitis was higher in group II (7 of 38 eyes; 18.42%) compared to group I (2 of 32 eyes; 6.25%). Both the patients who developed endophthalmitis despite prophylactic intravitreal antibiotics in group I had an initially undetected intraocular foreign body (eyelash) in the vitreous cavity.
Conclusions: Prophylactic intravitreal broad spectrum antibiotic injection decreases the risk of post-traumatic endophthalmitis.
Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh
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