Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 2271
  • Home
  • Print this page
  • Email this page
Year : 2003  |  Volume : 51  |  Issue : 1  |  Page : 59-65

Comparison of single-drop mitomycin C regime with other mitomycin C regimes in pterygium surgery.

Department of Ophthalmology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India

Correspondence Address:
Ved P Gupta
Department of Ophthalmology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 12701864

Rights and PermissionsRights and Permissions

Purpose: To evaluate the safety and efficacy of single-drop instillation of mitomycin C (MMC) in pterygium surgery and to compare the results with both postoperative and intraoperative application of MMC. Methods: Eighty eyes of 72 patients with pterygium were randomised into 4 equal groups: group 1 - control - bare scleral excision (BSE); group 2 - BSE with single-drop instillation of mitomycin C (MMC) 0.02% at the end of the surgery; group 3 - BSE with postoperative MMC 0.02% drops twice a day for 5 days; and group 4 - BSE with intraoperative MMC 0.02%. Results: The recurrence of pterygium was observed in 14 (70%), 4 (20%), 4 (20%) and 3 (15%) eyes of group 1, 2, 3, and 4 respectively. The recurrence rate after BSE with single drop MMC regime (group 2) was significantly lower than group 1 recurrence ( P = 0.001) and was statistically comparable to that of group 3 and 4. Scleral defects in the bare area occurred in 4 (20%), 16 (80%) and 16 (80%) eyes of group 2, 3, and 4 respectively. The incidence of scleral defects was significantly lower in group 2 compared to group 3 (P=0.0001) and group 4 (P=0.0001). Compared to group 1 and 2, a significant delay in wound epithelialisation occurred in group 3 ( P=0.003) and 4 ( P=0.004). An ischaemic area in the bare sclera developed in 8 (40%) and 6 (30%) eyes of group 3 and 4 respectively, while ischaemic area did not develop in group 1 and 2. Conclusion: Single-drop instillation of 0.02% mitomycin C following pterygium excision appears both safe and efficacious.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded423    
    Comments [Add]    
    Cited by others 8    

Recommend this journal