Glyxambi
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 4024
  • Home
  • Print this page
  • Email this page

   Table of Contents      
BRIEF REPORT
Year : 2005  |  Volume : 53  |  Issue : 4  |  Page : 274-275

Ruthenium-106 plaque brachytherapy for the treatment of diffuse choroidal haemangioma in Sturge-Weber syndrome


Ocular Oncology Service, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500 034, India

Correspondence Address:
Santosh G Honavar
Ocular Oncology Service, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500 034
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.18913

Rights and Permissions

How to cite this article:
Murthy R, Honavar SG, Naik M, Gopi S, Reddy VP. Ruthenium-106 plaque brachytherapy for the treatment of diffuse choroidal haemangioma in Sturge-Weber syndrome. Indian J Ophthalmol 2005;53:274-5

How to cite this URL:
Murthy R, Honavar SG, Naik M, Gopi S, Reddy VP. Ruthenium-106 plaque brachytherapy for the treatment of diffuse choroidal haemangioma in Sturge-Weber syndrome. Indian J Ophthalmol [serial online] 2005 [cited 2019 Nov 13];53:274-5. Available from: http://www.ijo.in/text.asp?2005/53/4/274/18913

Choroidal haemangioma is a benign vascular tumour, which can be circumscribed or diffuse. Haemangiomas of the brain, orbit and the periocular skin coexist with diffuse choroidal haemangioma as part of the Sturge-Weber syndrome.

Diffuse choroidal haemangioma may be associated with an exudative retinal detachment with macular involvement, photoreceptor cell loss and cystoid degeneration of the sensory retina causing visual loss[1] and is classically treated with external beam radiotherapy.[2],[3] We report a case of a diffuse choroidal haemangioma with exudative retinal detachment that showed remarkable response to plaque brachytherapy.


  Case Report Top


A 10-year-old girl presented with blurred vision in the right eye of 1-month duration. On examination, her best-corrected visual acuity (BCVA) was 6/60 in the right eye and 6/6 in the left eye. She had diffuse nevus flammeus involving the right upper eyelid, cheek and the nose suggestive of Sturge-Weber syndrome. Anterior segment was normal. There was no evidence of glaucoma. Fundus examination showed total exudative retinal detachment and diffuse choroidal haemangioma. There was a nodular elevation arising from the diffuse choroidal haemangioma measuring about 12 mm in greatest diameter, localised to the posterior pole [Figure - 1]A. Ultrasound B-scan confirmed diffuse thickening of the choroid. The tumour was thickest at the posterior pole measuring 5.25 mm [Figure 2]A. Computed tomography scan of the brain and systemic evaluation were unremarkable.

The tumour was treated with a notched 20 mm diameter Ruthenium-106 plaque (Bebig Isotopen, Germany) centered on the nodular elevation with a tumour apex dose of 3000 cGy, dose rate of 68 cGy/h and a treatment time of 44 h.

At 1-month posttreatment, the maximum thickness of the haemangioma had decreased to 2.57 mm with complete resorption of the subretinal fluid [Figure - 1]B,[Figure 2]B. The BCVA was 6/15. After 3 months, the BCVA was 6/9 and the tumour was nearly flat. No radiation-induced complications were noted after 22 months following brachytherapy and the visual acuity was stable.


  Discussion Top


Mac Lean and associates were probably the first to use brachytherapy for the treatment of choroidal haemangioma.[4] They used transscleral diathermy with scleral suturing of radon seeds. Episcleral plaque brachytherapy is currently considered an effective treatment for large circumscribed choroidal haemangiomas with subretinal fluid.[5],[6] The safety and efficacy of Cobalt 60 and Iodine 125 plaques has been demonstrated.[5],[6]

Lens-sparing external beam radiotherapy has been recommended for diffuse choroidal haemangiomas with subretinal fluid.[2],[3] However, there is slow absorption of subretinal fluid usually taking several months.[2] Often, there is a recurrence or persistence of the fluid necessitating additional external beam radiotherapy with the risk of cataract, radiation retinopathy and optic atrophy.[2]

As far as could be ascertained (medline search) there is only one report in the literature treating diffuse choroidal haemangiomas with plaque brachytherapy. Zografos and associates used Cobalt-60 applicators in two patients with diffuse choroidal haemangiomas.[5] They found complete resolution of the subretinal fluid and tumour regression in these cases with results comparable to the circumscribed form.

The advantage of plaque brachytherapy is that it delivers precise focal radiation to the target area with minimal damage to the normal ocular structures. We used a large diameter plaque with a notch to accommodate the optic nerve and centered it on the thickest portion of the diffuse choroidal haemangioma. In our patient, the subretinal fluid was completely resolved in 1 month with consequent improvement in visual acuity. The diffuse choroidal haemangioma showed rapid regression in thickness demonstrable on ultrasound. The rapidity of clinical response and lack of complications was impressive. Plaque brachytherapy may thus prove to be a viable treatment option for diffuse choroidal haemangiomas with subretinal fluid in patients with Sturge-Weber syndrome.

 
  References Top

1.
Witschel H, Font RL. Hemangioma of the choroid. A clinicopathologic study of 71 cases and a review of the literature. Surv Ophthalmol 1976;20:415-31.  Back to cited text no. 1
[PUBMED]    
2.
Madreperla SA, Hungerford JL, Plowman PN, Laganowski HC, Gregory PT. Choroidal hemangiomas: visual and anatomic results of treatment by photocoagulation or radiation therapy. Ophthalmology 1997;104:1773-8.  Back to cited text no. 2
[PUBMED]    
3.
Gottleib JL, Murray TG, Gass JD. Low dose external beam irradiation for choroidal hemangiomas. Arch Ophthalmol 1998;116:815-7.  Back to cited text no. 3
    
4.
Mac Lean AL, Maumenee E. Hemangioma of the choroid. Am J Ophthalmol 1960;50:3-11.  Back to cited text no. 4
    
5.
Zografos L, Bercher L, Chamot L, Gailloud C, Raimondis, Egger E. Cobalt-60 treatment of choroidal hemangiomas. Am J Ophthalmol 1996;121:190-9.  Back to cited text no. 5
    
6.
Shields CL, Honavar SG, Shields JA, Cater J, Demirci H. Circumscribed choroidal hemangioma: clinical manifestations and factors predictive of visual outcome in 200 consecutive cases. Ophthalmology 2001;108:2237-48.  Back to cited text no. 6
[PUBMED]    


    Figures

  [Figure - 1]


This article has been cited by
1 Diffuse Choroidal Hemangioma Management with Plaque Radiotherapy in 5 Cases
Sruthi Arepalli,Carol L. Shields,Swathi Kaliki,Jacqueline Emrich,Lydia Komarnicky,Jerry A. Shields
Ophthalmology. 2013; 120(11): 2358
[Pubmed] | [DOI]
2 Ruthenium-106 brachytherapy and intravitreal bevacizumab for retinal capillary hemangioma
Vincenzo Russo, Andrea Stella, Antonio Barone, Ingrid U. Scott, Nicola Delle Noci
International Ophthalmology. 2012;
[VIEW] | [DOI]
3 Photodynamic therapy of choroidal hemangioma in sturge-weber syndrome, with a review of treatments for diffuse and circumscribed choroidal hemangiomas
Tsipursky, M.S., Golchet, P.R., Jampol, L.M.
Survey of Ophthalmology. 2011; 56(1): 68-85
[Pubmed]
4 Photodynamic Therapy of Choroidal Hemangioma in Sturge-Weber Syndrome, with a Review of Treatments for Diffuse and Circumscribed Choroidal Hemangiomas
Michael S. Tsipursky,Pamela R. Golchet,Lee M. Jampol
Survey of Ophthalmology. 2011; 56(1): 68
[Pubmed] | [DOI]
5 Sturge-Weber syndrome: Report of 2 cases
Li, X.-F., Mao, D.-A., Liu, L.-Q.
Chinese Journal of Contemporary Pediatrics. 2007; 9(5): 504-505
[Pubmed]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Case Report
Discussion
References
Article Figures

 Article Access Statistics
    Viewed4222    
    Printed151    
    Emailed1    
    PDF Downloaded272    
    Comments [Add]    
    Cited by others 5    

Recommend this journal