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ORIGINAL ARTICLE
Year : 2006  |  Volume : 54  |  Issue : 1  |  Page : 29-34

Clinical outcome of autologous cultivated limbal epithelium transplantation


1 Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory, Cornea and Anterior Segment Service, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, India
2 Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory, Ophthalmic Pathology Laboratory, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, India
3 Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, India
4 Center for Cellular and Molecular Biology, Hyderabad, India
5 International Center for Advancement of Rural Eye Care, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, India
6 Cornea and Anterior Segment Service, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, India

Correspondence Address:
Virender S Sangwan
L.V. Prasad Eye Institute, L. V. Prasad Marg, Banjara Hills, Hyderabad 500034
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.21611

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Purpose: To report the clinical outcome of autologous cultivated limbal epithelial transplantation. Methods: Eighty-six patients' records and their clinical photographs were reviewed for demographics, primary etiology, type of limbal transplantation, ocular surface stability, visual acuity, final outcome, and possible factors affecting outcome and complications. Results: Eighty-eight eyes of 86 patients with limbal stem cell deficiency (LSCD) underwent autologous cultivated limbal epithelium transplantation between March 2001 and May 2003, with a mean follow-up of 18.3 months. The etiology of LSCD was alkali burns in 64% patients. Sixty-one eyes had total LSCD. Thirty-two of the 88 eyes had undergone amniotic membrane transplantation and 10 eyes had previously undergone limbal transplantation with unfavorable outcome. Nineteen eyes underwent penetrating keratoplasty, of which 11 grafts survived at the final follow-up. Finally, 57 eyes (73.1%, 95% CI: 63.3-82.9) had a successful outcome with a stable ocular surface without conjunctivalization, 21 eyes (26.9%, 95%CI: 17.1-36.7) were considered failures, and 10 patients were lost to follow-up. Conclusion: LSCD can be successfully treated by autologous cultivated limbal epithelium transplantation in majority of the cases.


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