Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 3663
  • Home
  • Print this page
  • Email this page

   Table of Contents      
Year : 2007  |  Volume : 55  |  Issue : 3  |  Page : 219-221

Craniodiaphyseal dysplasia: An unusual cause of recurrent dacryocystitis

Department of Radio Diagnosis, All India Institute of Medical Sciences, New Delhi - 110 029, India

Date of Submission22-Feb-2006
Date of Acceptance08-Jul-2006

Correspondence Address:
G Shivanand
C/o. Vijay Kumar Uppal, 198/58, East of Kailash, Uppal's House, Ramesh Market, New Delhi - 110 065
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0301-4738.31945

Rights and Permissions

We describe a rare syndrome characterized by severe craniofacial hyperostosis, sclerosis, obliteration of paranasal sinuses and foramina of skull base, in a 10-year-old female child who presented with abnormal facial features and recurrent dacryocystitis due to narrowing of nasolacrimal duct.

Keywords: Bone dysplasia, craniodiaphyseal dysplasia, dacryocystitis.

How to cite this article:
Shivanand G, Kandpal H. Craniodiaphyseal dysplasia: An unusual cause of recurrent dacryocystitis. Indian J Ophthalmol 2007;55:219-21

How to cite this URL:
Shivanand G, Kandpal H. Craniodiaphyseal dysplasia: An unusual cause of recurrent dacryocystitis. Indian J Ophthalmol [serial online] 2007 [cited 2020 Mar 28];55:219-21. Available from: http://www.ijo.in/text.asp?2007/55/3/219/31945

Craniodiaphyseal dysplasia is a very severe bone dysplasia characterized by "massive hyperostosis and sclerosis involving skull and facial bones".[1] We report a case of craniodiaphyseal dysplasia in a 10-year-old female who presented with recurrent episodes of dacryocystitis and abnormal facial features. To the best of our knowledge only two such cases have been reported earlier,[2],[3] but ours is the first to document the narrowing of the nasolacrimal duct on computed tomography (CT).

  Case Report Top

A 10-year-old-female child presented to our hospital with left-sided epiphora and abnormal features. There was no family history of similar complaints or other genetic disorders. The child was born to parents who had a non-consanguineous marriage and were healthy. The pregnancy and delivery were unremarkable. No abnormalities were noted at birth. At the age of nine years, the parents noted abnormal facial features and persistent lacrimation of left eye, in their child.

Physical examination revealed grossly deformed head, short stature, hypertelorism and epiphora of left eye. The jaw was prominent and there was kyphoscoliosis of dorsal spine. The fundus examination was normal. The neurological examination was normal and child had normal intelligence quotient. The biochemical parameters such as serum calcium, serum phosphate, alkaline phosphatase, renal function tests and liver function tests were normal.

The skeletal radiographs revealed extensive thickening and sclerosis of calvarial and facial bones [Figure - 1], moderate widening and sclerosis of clavicles and ribs [Figure - 2], straight and cylindrical diaphysis of long bones [Figure - 3] and, increased density of neural arches of vertebrae (not shown). Subsequently, CT scan of head and orbit was done, which revealed significant narrowing of the left nasolacrimal duct, obliteration of paranasal sinuses [Figure - 4] and narrowing of optic canals and external auditory canals (not shown). Based on imaging findings, the diagnosis of craniodiaphyseal dysplasia was made.

  Discussion Top

Craniodiaphyseal dysplasia is the rarest of all sclerosing bone dysplasia, so far less than 30 cases have been reported in the English literature. It was first described by Gorlin et al. in 1969 as a very severe bone disorder characterized by massive hyperostosis and sclerosis, especially involving skull and facial bones. [1] Earlier to this, Halliday and Joseph et al. in 1949 and 1958 respectively, had reported cases with similar features. However, at that time these cases were considered to be a variant of the Camurati-Engelmann disease.[4],[5]

This dysplasia is inherited as an autosomal recessive trait with complete penetrance and variable expression, but autosomal dominant inheritance has also been reported.[2] The basic abnormality is still not known, it has been thought that either excessive osteoblastic activity or abnormality in calcium and phosphate metabolism might be responsible.[6] The affected patients typically present in early infancy with facial abnormalities such as paranasal bossing, hypertelorism and increased head circumference. Occasionally, they may present with recurrent dacryocystitis because of progressive stenosis of the nasolacrimal duct, which happened in our case.[2],[3] None of these case reports of craniodiaphyseal dysplasias have documented the narrowing of the nasolacrimal duct on CT scan. In our case the main complaint of the patient was epiphora of the left eye, which was likely due to the narrowing of the nasolacrimal duct and it was well demonstrated on CT scan. These patients may also present with respiratory difficulty due to nasal obstruction, blindness, deafness or cranial nerve palsies due to progressive bony encroachment upon cranial foramina. The prognosis of this dysplasia is very poor because of inevitable progression.[6] Radiologically, this syndrome has to be differentiated from other dysplasias such as Camurati-Engelmann disease, Van Buchem's dysplasia and craniotubular dysplasias.[7] In Camurati-Engelmann, the degree of cranio-facial involvement is mild with major changes in long bones. In Van Buchem's dysplasia, mandibular enlargement is the predominant manifestation, head circumference is normal and facial changes manifest in the second decade. In craniotubular dysplasia, there is metaphyseal widening and cortical thinning giving rise to club-shaped configuration of long bones whereas in craniodiaphyseal dysplasia the diaphyseal widening gives rise to cylindrical appearance, however, the skull changes are nearly the same except for prominence of the supra-orbital ridge.

  References Top

Gorlin RJ, Spranger J, Koszalka MF. Genetic craniotubular bone dysplasias and hyperostosis: A critical analysis. Birth Defects 1969;5:79-95.  Back to cited text no. 1
Schaefer B, Stein S, Oshman D, Rennert O, Thurnau G, Wall J, et al . Dominantly inherited craniodiaphyseal dysplasia: A new craniotubular dysplasia. Clin Genet 1986;30:381-91.  Back to cited text no. 2
McHugh DA, Rose GE, Garner A. Nasolacrimal obstruction and facial bone histopathology in craniodiaphyseal dysplasia. Br J Ophthalmol 1994;78:501-3.  Back to cited text no. 3
Halliday J. A rare case of bone dystrophy. Br J Surg 1949;37:52-63.  Back to cited text no. 4
Joseph R, Lefebvre J, Guy E, Job JC. Dysplasie craniodiaphysaire progressive. Ses relations avec la dysplasia diaphysarire progressive de Camurati-Engelmann. Ann Radiol 1958;1:477-90.  Back to cited text no. 5
Brueton LA, Winter RM. Craniodiaphyseal dysplasia. J Med Genet 1990;27:701-6.  Back to cited text no. 6
Janssens K, Thompson E, Vanhoenacker F, Savarirayan R, Morris L, Dobbie A, et al . Macrocephaly and sclerosis of the tubular bones in an isolated patient: A mild case of craniodiaphyseal dysplasia? Clin Dysmorphol 2003;12:245-50.  Back to cited text no. 7


  [Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4], [Figure - 5]

This article has been cited by
1 Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia
Human Genetics. 2011;
[VIEW] | [DOI]
2 Acquired Chiari malformation secondary to hyperostosis of the skull: a case report and literature review
Ladislau Albert,Alan Hirschfeld
Surgical Neurology. 2009; 72(2): 157
[Pubmed] | [DOI]
3 "A probable case of craniodiaphyseal dysplasia - A rare entity"
Kamdar, P.K., Shah, V.
Journal of Clinical and Diagnostic Research. 2009; 3(3): 1573-1576
4 Acquired Chiari malformation secondary to hyperostosis of the skull: a case report and literature review
Albert Jr., L., Hirschfeld, A.
Surgical Neurology. 2009; 72(2): 157-161


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
Case Report
Article Figures

 Article Access Statistics
    PDF Downloaded1492    
    Comments [Add]    
    Cited by others 4    

Recommend this journal