Glyxambi
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 609
  • Home
  • Print this page
  • Email this page

   Table of Contents      
BRIEF REPORT
Year : 2007  |  Volume : 55  |  Issue : 6  |  Page : 475-477

Systemic chemotherapy and tamoxifen induced regression of choroidal metastasis from a breast carcinoma in a male


1 Department of Ophthalmic and Facial Plastic Surgery, Orbital Diseases and Ocular Oncology, Aditya Jyot Eye Hospital Pvt Ltd; Department of Ocular Oncology, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Mumbai, India
2 Department of Retina, Aditya Jyot Eye Hospital Pvt. Ltd, Mumbai, India
3 Department of Cornea and Anterior Segment, Aditya Jyot Eye Hospital Pvt. Ltd, Mumbai, India

Date of Submission05-Jul-2006
Date of Acceptance21-Mar-2007

Correspondence Address:
Debraj Shome
Department of Ophthalmic and Facial Plastic Surgery, Orbit and Ocular Oncology, Aditya Jyot Eye Hospital Pvt Ltd, Plot No 153, Road No 9, Major Parmeshwaran Road, Wadala, Mumbai - 400 031
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.36491

Rights and Permissions
  Abstract 

We report a case of a 55-year-old male patient with breast carcinoma, who developed choroidal metastasis. The patient had undergone mastectomy for carcinoma of right breast, five years ago. The patient was advised close follow-up for the left eye, as he was already on tamoxifen therapy (started a month ago) for spinal metastasis. On last follow-up, a year later, the choroidal lesion had completely scarred, with no recurrences. Systemic hormonal therapy like tamoxifen given for the breast primary and other systemic metastases may cause regression of the choroidal metastasis, thereby avoiding ocular radiotherapy. Medline search revealed only one published case of regression of choroidal metastasis from a male breast primary, on tamoxifen therapy.

Keywords: Choroidal metastasis, male breast carcinoma, tamoxifen


How to cite this article:
Shome D, Jayadev C, Gadgil D, Natarajan S, Jain V. Systemic chemotherapy and tamoxifen induced regression of choroidal metastasis from a breast carcinoma in a male. Indian J Ophthalmol 2007;55:475-7

How to cite this URL:
Shome D, Jayadev C, Gadgil D, Natarajan S, Jain V. Systemic chemotherapy and tamoxifen induced regression of choroidal metastasis from a breast carcinoma in a male. Indian J Ophthalmol [serial online] 2007 [cited 2019 Dec 11];55:475-7. Available from: http://www.ijo.in/text.asp?2007/55/6/475/36491

Choroidal metastases occur most frequently from the breast in females and from the lungs in males. [1] Breast carcinoma in males is very rare, accounting for 1% of all breast carcinomas, with choroidal metastasis in males being still rarer. [2] We report a male patient with breast carcinoma with choroidal metastasis, which regressed on systemic tamoxifen therapy.


  Case Report Top


A 55-year-old male patient presented with complaints of sudden, painless decrease of vision in the left eye, since 10 days. Past history was significant for right breast carcinoma and subsequent mastectomy, five years ago [Figure - 1]. Yearly routine evaluation had revealed spinal metastasis, a month prior to presentation with ocular symptoms. As the metastasis and the primary were both very high in hormonal receptors, the medical oncologist had started the patient on oral tamoxifen 20 mg a day, for the spinal metastasis.

The best corrected visual acuity (BCVA) was 20/60 and 3/120, in the right and left eye respectively. Right eye and left eye anterior segment examination was unremarkable.

Left fundus examination revealed a grayish yellow macular mass; approximately 20x15 mm in size, with surrounding exudative retinal detachment [Figure - 2]a. Ultrasonography (USG) B-Scan of the left eye showed a raised subretinal mass with high surface reflectivity and moderate internal reflectivity, associated with a surrounding retinal detachment [Figure - 2]b. Fundus fluorescein angiography could not be performed as the patient refused any invasive diagnostic intervention. A choroidal metastasis from the breast carcinoma was diagnosed. The patient refused ocular external beam radiotherapy (EBRT) for the choroidal lesion and was advised close follow-up, every three months, as he was already on systemic hormonal therapy started a month ago.

The choroidal lesion gradually scarred, with complete absorption of subretinal fluid.

On final follow-up one year later, the choroidal lesion had completely healed with scarring [Figure - 3]a with no recurrences in either eye. The USG B-scan of the left eye showed flattening of the subretinal mass [Figure - 3]b. Optical coherence tomography of the left eye revealed no sign of activity [Figure - 3]c. The BCVA was counting fingers at two feet, at final visit.


  Discussion Top


Breast carcinoma in males presenting with a median age of 67 years is virtually silent, hence needing a high index of suspicion for diagnosis. [3] Systemic chemotherapy [4] and hormonal therapy [5] given for the systemic condition have been reported to cause regression of choroidal metastasis. This obviates the need for ocular intervention like radiotherapy, preventing its side-effects. Breast carcinoma in males has a higher concentration of estrogen and progesterone receptors than in the female, thus rendering both the primary and the metastasis more susceptible to hormonal manipulation. [5]

The probable reason why there is only one reported case of regression on tamoxifen therapy may be partly because choroidal metastasis in breast carcinoma in males is so rare and also partly because most clinicians and patients opt for localized radiotherapy as a mode of control of the choroidal lesion. It is difficult to comment on whether the patient would have had better final visual acuity if the fundus lesion had been subjected to EBRT. EBRT usually leads to a flat scar while in this case there was elevated scarring. It would not be possible to comment on the above without evaluating two sets of patients, one of whom was subjected to ocular EBRT versus another treated with systemic therapy alone. But, in debilitated patients who refuse EBRT with its associated ocular side-effects as a mode of therapy, it may be worthwhile to remember that hormonal therapy may itself cause regression of the choroidal mass. This might also have some clinical relevance for females with choroidal metastases from breast carcinoma.

In summary, we report a case of breast carcinoma in males with suspected choroidal metastasis which completely healed with systemic hormonal therapy. We report this case to highlight this rare source of choroidal metastasis, in males and to document the role of systemic therapy in its regression.

 
  References Top

1.
Chong JT, Mick A. Choroidal metastasis: case reports and review of the literature. Optometry 2005;76:293-301.  Back to cited text no. 1
[PUBMED]    
2.
Carmalt HL, Mann LJ, Kennedy CW, Fletcher JM, Gillett DJ. Carcinoma of the male breast: A review and recommendations for management. Aust N Z J Surg 1998;68:712-5.  Back to cited text no. 2
[PUBMED]    
3.
Donegan WL, Redlich PN. Breast cancer in men. Surg Clin North Am 1996;76:343-63.  Back to cited text no. 3
[PUBMED]    
4.
Paoli D. Regression of choroidal metastasis from a carcinoma of the male breast: Case report. Ophthalmologica 1998;212:74-6.  Back to cited text no. 4
[PUBMED]  [FULLTEXT]  
5.
Cohen VM, Moosavi R, Hungerford JL. Tamoxifen-induced regression of a choroidal metastasis in a man. Arch Ophthalmol 2005;123:1153-4.   Back to cited text no. 5
[PUBMED]    


    Figures

  [Figure - 1], [Figure - 2], [Figure - 3]


This article has been cited by
1 Male breast carcinoma metastatic to the choroid: Report of 3 cases and review of the literature
Hood, C.T., Budd, G.T., Nicholas Zakov, Z., Singh, A.D.
European Journal of Ophthalmology. 2011; 21(4): 459-467
[Pubmed]
2 Uveal metastatic tumor: Literature review about the most common eye malignancy | [Tumor metastático uveal: Revisão de literatura sobre a neoplasia ocular maligna mais comum]
Meyer, I.
Revista Brasileira de Oftalmologia. 2011; 70(1): 51-56
[Pubmed]
3 THE CASE
Radiologist, C. and Amman, J.
Bahrain Medical Bulletin. 2008; 30(4)
[Pubmed]
4 Unilateral symptomatic choroidal metastasis as the initial presentation of advanced breast carcinoma
Smadi, A.A.
Bahrain Medical Bulletin. 2008; 30(4): 185-187
[Pubmed]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Abstract
Case Report
Discussion
References
Article Figures

 Article Access Statistics
    Viewed2210    
    Printed46    
    Emailed3    
    PDF Downloaded217    
    Comments [Add]    
    Cited by others 4    

Recommend this journal