BRIEF COMMUNICATION |
|
Year : 2008 | Volume
: 56
| Issue : 5 | Page : 430-434 |
|
Familial unilateral Brown syndrome
Nihal Kenawy1, Daniela T Pilz2, Patrick Watts3
1 St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, L7 8XP, United Kingdom 2 Institute of Medical Genetics, University Hospital of Wales, Cardiff, CF14 4XW, United Kingdom 3 Department of Ophthalmology, University Hospital of Wales, Cardiff, CF14 4XW, United Kingdom
Correspondence Address:
Patrick Watts University Hospital of Wales, Heath Park, Cardiff, CF14 4XW United Kingdom
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/0301-4738.42427
|
|
We present a two-generation family with Brown syndrome. The proband was a six and a half-year-old female who presented with a history of failure of dextro-elevation of her left eye. A full ophthalmic evaluation was consistent with a left Brown syndrome. Family history revealed that her mother was operated on as a child for left Brown syndrome and examination of her four and a half-year-old sibling showed similar affection in the left eye. Autosomal dominant inheritance has been postulated in this condition. To our knowledge this is the first report of three members of a two-generation family with left-sided Brown syndrome. Genetic counseling of Brown syndrome cases is advised; nevertheless, identification of the responsible gene should shed more light on its genetics. |
|
|
|
[FULL TEXT] [PDF]* |
|
|
|