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BRIEF COMMUNICATION
Year : 2008  |  Volume : 56  |  Issue : 6  |  Page : 507-509

Isolated lacrimal gland involvement in Rosai-Dorfman-Destombes disease


1 Department of Histopathology, Sir Ganga Ram Hospital, New Delhi, India
2 Department of Ophthalmology, Sir Ganga Ram Hospital, New Delhi, India

Correspondence Address:
Hanni Gulwani
Department of Histopathology, New Building, First Floor, Old Rajinder Nagar, Sir Ganga Ram Hospital, New Delhi-110 060
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.43375

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Rosai-Dorfman-Destombes (sinus histiocytosis with massive lymphadenopathy) disease is an uncommon disease characterized by benign proliferation of histiocytes, with painless lymph node enlargement and frequent extranodal disease. Orbital involvement occurs in 9-11% of cases. However, isolated Rosai-Dorfman-Destombes disease of the lacrimal gland without any systemic involvement is very rare with only three case reports. We describe here one such young male patient with unilateral lacrimal gland swelling. Excision biopsy revealed almost complete replacement of the lacrimal gland by lymphocytes, plasma cells and large pale histiocytes. The latter exhibited emperipolesis and stained positive for S-100 and CD68 on immunohistochemistry. Patient is well and has no other manifestation or recurrence of the disease during a follow-up of 24 months.


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