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BRIEF COMMUNICATION
Year : 2010  |  Volume : 58  |  Issue : 1  |  Page : 76-78

Intravitreal anti-vascular endothelial growth factor agents as an adjunct in the management of Coats' disease in children


Department of Pediatric Ophthalmology and Strabismology, Aditya Jyot Eye Hospital Pvt Ltd, Mumbai, India

Correspondence Address:
Shalini Kaul
Department of Pediatric Ophthalmology and Strabismology, Aditya Jyot Eye Hospital Pvt. Ltd, Plot no 153, Road no 9. Major Parmeswaran Road, Wadala, Mumbai - 31
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.58480

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We describe the role of intravitreal anti-vascular endothelial growth factor (VEGF) agents in Coats' disease in children. In a prospective, interventional, non-randomized case series, three patients (three eyes) aged 16, seven and two years were diagnosed to have Coats' disease. In Case 1 (16 yr/ male) with macular edema, previous laser photocoagulation being unsuccessful, intravitreal pegaptanib sodium (Macugen™) was tried. Case 2 (seven yr/ male) and Case 3 (two yr/ female) were diagnosed to have Stage 4 Coats' and underwent external needle drainage, laser photocoagulation, SF6 gas injection and intravitreal injection of bevacizumab (Avastin™). Reduction of exudation and attached posterior pole (Cases 2 and 3) was seen at a follow-up of six months and two months respectively. Intravitreal anti-VEGF agents may be successfully used as adjunct treatment in select cases of Coats' disease in childhood.


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