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LETTER TO EDITOR
Year : 2010  |  Volume : 58  |  Issue : 2  |  Page : 173-175

Spectral domain optical coherence tomography predates fluorescein angiography in diagnosing central serous chorioretinopathy


Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Date of Web Publication26-Feb-2010

Correspondence Address:
Vishali Gupta
Department of Ophthalmology, Advanced Eye Centre Post Graduate Institute of Medical Education and Research, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.60084

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How to cite this article:
Gupta V, Gupta A, Gupta P. Spectral domain optical coherence tomography predates fluorescein angiography in diagnosing central serous chorioretinopathy. Indian J Ophthalmol 2010;58:173-5

How to cite this URL:
Gupta V, Gupta A, Gupta P. Spectral domain optical coherence tomography predates fluorescein angiography in diagnosing central serous chorioretinopathy. Indian J Ophthalmol [serial online] 2010 [cited 2020 Feb 27];58:173-5. Available from: http://www.ijo.in/text.asp?2010/58/2/173/60084

Dear Editor,

Central serous chorioretinopathy (CSCR) is characterized by the development of serous retinal detachment in the macula and is mainly diagnosed by fluorescein angiography that shows one or multiple areas of leakage from the retinal pigment epithelium (RPE) seen as "expanding dot" or "smoke stack" sign. [1],[2] The RPE defect corresponding to the dominant hyperfluorescence in the fluorescein angiogram, is believed to be the cause for serous leakage of fluid into the subretinal space and is seen as a pigment epithelium detachment (PED) on time domain Stratus Optical coherence tomography (OCT). [3] We present a case of CSCR where the spectral domain high-definition (HD) Cirrus OCT (Carl Zeiss Meditec) could diagnose subclinical CSCR before the development of the expanding dot sign on fluorescein angiography.

A 40-year-old man was seen with complaints of blurred vision in his left eye with a visual acuity of 20/30 and was diagnosed to be suffering from CSCR in this eye. His right eye was asymptomatic with a visual acuity of 20/20. On fluorescein angiography, multiple areas of hyperfluorescence were seen that were diagnosed as PED. No expanding dot sign was seen at this stage in the right eye [Figure 1] while the left eye showed multiple hyperfluroscence with late leakage [Figure 2]. Analysis of the single-layer RPE showed elevations in the corresponding areas [Figure 3]. A raster line scan of the right eye showed PED with serous retinal detachment [Figure 4]. Similarly, the left eye showed PED with a serous retinal detachment [Figure 2]. The patient was under regular follow-up for next few months. Three months later, the patient complained of blurred vision in his right eye (20/30) that now showed an expanding dot sign on fluorescein angiography [Figure 5]. Repeat analysis of the single RPE layer now showed increased irregularity with bumps in the superior half [Figure 5].

The diagnosis of CSCR is mainly clinical, aided by fluorescein angiography and OCT. Fluorescein angiography classically shows the leakage of dye from the choroid through a focal RPE defect and its pooling in the subretinal space in acute CSCR. OCT is traditionally used to quantify the amount and extent of the subretinal fluid, demonstrate thickening of the neural retina and is commonly used for monitoring during the follow-up and also for diagnosing the changes in the neurosensory retina that can cause permanent impairment in vision in such eyes. [3],[4] Recently, 3D high-speed OCT has shown to facilitate the understanding of pathophysiologic changes in CSCR. [5] However, this case illustrates that spectral domain HD OCT could pick up the presence of the subretinal fluid and RPE changes even before they could manifest angiographically in CSCR. This indeed may be a better tool for monitoring the asymptomatic eye for the detection of early changes and may obviate the need for fluorescein angiography in selected cases. However, this is only a case report and a larger study is required.

 
  References Top

1.
Gass JD. Pathogenesis of disciform detachment of the neuroepithelium. II. Idiopathic central serous choroidopathy. Am J Ophthalmol 1967;63:587-615.  Back to cited text no. 1
    
2.
Klein ML, Van Buskirk EM, Friedman E, Gragoudas E, Chandra S. Experience with non-treatment of central serous choroidopathy. Arch Ophthalmol 1974;91:247-50.  Back to cited text no. 2
    
3.
Iida T, Hagimura N, Sato T, Kishi S. Evaluation of central serous chorioretinopathy with optical coherence tomography. Am J Ophthalmol 2000;129:16-20.  Back to cited text no. 3
    
4.
Gupta V, Gupta A, Dogra MR. Atlas: Optical Coherence Tomography of Macular diseases and Glaucoma. 2 nd ed. N. Delhi India: Jaypee Brs Med Publishers (P) Ltd; 2006. p. 72-103.  Back to cited text no. 4
    
5.
Ojima Y, Hangai M, Sasahara M, Gotoh N, Inoue R, Yasuno Y, et al. Three-dimensional Imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography. Ophthalmol 2007;114:2197-207.  Back to cited text no. 5
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]


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