Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 3656
  • Home
  • Print this page
  • Email this page

   Table of Contents      
LETTER TO EDITOR
Year : 2010  |  Volume : 58  |  Issue : 2  |  Page : 175-176

Phrynoderma and night blindness


1 Department of Paediatric ophthalmology and Strabismus, Prabha Eye Clinic and Vittala International Institute of Ophthalmology, Bangalore, India
2 Department of Paediatric ophthalmology, Strabismus and Oculoplasty, Prabha Eye Clinic and Vittala International Institute of Ophthalmology, Bangalore, India

Date of Web Publication26-Feb-2010

Correspondence Address:
Venkatesh C Prabhakaran
Department of Paediatric ophthalmology, Strabismus and Oculoplasty, Prabha Eye Clinic and Vittala International Institute of Ophthalmology, Bangalore
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.60089

Rights and Permissions

How to cite this article:
Murthy SR, Prabhakaran VC. Phrynoderma and night blindness. Indian J Ophthalmol 2010;58:175-6

How to cite this URL:
Murthy SR, Prabhakaran VC. Phrynoderma and night blindness. Indian J Ophthalmol [serial online] 2010 [cited 2020 Mar 28];58:175-6. Available from: http://www.ijo.in/text.asp?2010/58/2/175/60089

Dear Editor,

Phrynoderma is traditionally considered to be a skin manifestation of vitamin A deficiency as is night blindness in the eye. However, most recent investigators deny the link between phrynoderma and vitamin A and the association between phrynoderma and night blindness is highly unusual. We report a three-year-old patient who presented with night blindness and was found to have skin lesions typical of phrynoderma. Both conditions completely resolved with vitamin A therapy suggesting its causative role.

Ocular manifestations of vitamin A deficiency are referred to as xerophthalmia, earliest manifestation being night blindness. Others include conjuctival xerosis, Bitot's spots, corneal xerosis, keratomalacia, and corneal scarring. [1],[2] Skin lesions in the form of follicular keratosis or phrynoderma have been reported. [1],[2] Lesions typically are dry, hard, pigmented papules with 2-5 mm central intrafollicular keratotic plug projecting from hair follicles as horny spines resembling toad skin, hence the name phrynoderma. However, the link between phrynoderma and vitamin A deficiency is controversial and some reports suggest that this condition may be secondary to generalized malnutrition or essential fatty acid deficiency. [2],[3],[4] Night blindness associated with phrynoderma appears to be an exceedingly rare occurrence. [1],[2],[3],[4],[5]

A three-year-old female Indian child presented with history of night blindness of one month duration as ascertained by her parents. On examination, visual acuity appeared to be normal (central, steady, and maintained fixation in both eyes). The conjunctiva appeared lusterless suggesting xerosis. Anterior segment and dilated fundus examination with indirect ophthalmoscope was unremarkable. Further examination revealed dry, horny, papules with central intrafollicular plugging distributed over extensor aspects of elbows, knees, trunk and the back of the child. She also had dry, coarse and lusterless hair. A clinical diagnosis of phrynoderma and vitamin A deficiency was made. Serum vitamin A levels were not estimated as the parents were not willing for the test. Based on clinical findings, vitamin A therapy was considered appropriate. Vitamin A in a dose of 100,000 IU IM was administered on the day of presentation, and the following day. She was referred to a pediatrician for the management of malnutrition. One month follow-up showed complete resolution of skin lesions and parents had also noticed improvement of night blindness confirming the clinical diagnosis of vitamin A deficiency.

The simultaneous occurrence of night blindness and phrynoderma has rarely been reported in literature; to our knowledge, since Nicholls' original report in 1933, only one other case in the literature has documented the association of phrynoderrma and night blindness. [1],[2],[3],[4],[5] The earliest ocular manifestation of vitamin A deficiency being night blindness is well known. [1] Phrynoderma is traditionally considered to be a manifestation of vitamin A deficiency, [1] but a number of reports have denied its causative role. Investigators have proposed other causes such as generalized malnutrition and deficiencies of vitamin B, E, and essential fatty acids. [2],[3],[4]

Our case demonstrates the simultaneous occurrence of night blindness and phrynoderma, both of which resolved with vitamin A therapy. Though our patient was also malnourished, the effectiveness of vitamin A therapy suggests that at least in our patient, phrynoderma was secondary to vitamin A deficiency.[Figure 1],[Figure 2]

 
  References Top

1.
Nicholls L. Phrynoderma: A condition due to vitamin deficiency. Indian Med Gazette 1933; 68:681-7.  Back to cited text no. 1
    
2.
Shrank AB. Phrynoderma. Br Med J 1966;1:29-30.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.
Maronn M, Allen DM, Esterly NB. Phrynoderma: A manifestation of vitamin A deficiency? The rest of the story. Pediatr Dermatol 2005;22:60-3.  Back to cited text no. 3
    
4.
Soni BP, McLaren DS, Sheretz EF. Cutaneous changes in nutritional diseases. In: Freedberg IM, Eisen AZ, Wolff K, et al., editors. Fitzpatrick's dermatology in general medicine. 5 th ed. New York: McGraw-Hill; 1999. p. 1725-37.  Back to cited text no. 4
    
5.
Wechsler HL. Vitamin A deficiency following small bowel by pass surgery for obesity. Arch Dermatol 1979;115:73-5.  Back to cited text no. 5
[PUBMED]  [FULLTEXT]  


    Figures

  [Figure 1], [Figure 2]


This article has been cited by
1 Phrynoderma: A rare dermatologic complication of bariatric surgery
Ocón, J., Cabrejas, C., Altemir, J., Moros, M.
Journal of Parenteral and Enteral Nutrition. 2012; 36(3): 361-364
[Pubmed]
2 Phrynoderma in a patient with megaloblastic anemia
Sharma, V., Agarwal, M.P., Giri, S.
Indian Journal of Ophthalmology. 2011; 59(1): 72-73
[Pubmed]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
References
Article Figures

 Article Access Statistics
    Viewed2636    
    Printed56    
    Emailed0    
    PDF Downloaded157    
    Comments [Add]    
    Cited by others 2    

Recommend this journal