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BRIEF COMMUNICATION
Year : 2010  |  Volume : 58  |  Issue : 3  |  Page : 252-253

Acute postoperative endophthalmitis by Gemella haemolysans


1 Jhaveri Microbiology Centre, Hyderabad, India
2 Smt. Kanuri Santhamma Vitreoretinal Centre, Kallam Anji Reddy Campus, L.V. Prasad Eye Institute, Hyderabad, India

Date of Submission21-May-2009
Date of Acceptance03-Feb-2010
Date of Web Publication21-Apr-2010

Correspondence Address:
Suma Nalamada
Jhaveri Microbiology Centre, Hyderabad Eye Research Foundation, L.V. Prasad Eye Institute, Banjara Hills, Hyderabad-500 034
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.62658

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  Abstract 

Endophthalmitis is a rare and serious post-surgical complication. We report a case of acute postoperative endophthalmitis after an uneventful cataract surgery caused by a commensal organism, Gemella haemolysans. The patient was successfully treated with vitrectomy and intravitreal antibiotics like vancomycin, along with topical cefazolin.

Keywords: Endophthalmitis, Gemella haemolysans, intraocular vancomycin


How to cite this article:
Nalamada S, Jalali S, Reddy AK. Acute postoperative endophthalmitis by Gemella haemolysans. Indian J Ophthalmol 2010;58:252-3

How to cite this URL:
Nalamada S, Jalali S, Reddy AK. Acute postoperative endophthalmitis by Gemella haemolysans. Indian J Ophthalmol [serial online] 2010 [cited 2020 May 25];58:252-3. Available from: http://www.ijo.in/text.asp?2010/58/3/252/62658

Gemella haemolysans are aerobic or facultative anaerobic, gram-positive cocci which easily decolorize and appear as gram-negative diplococci. Because of this characteristic, the organism was originally classified under the genus Neisseria. Based on chemotaxomic studies, it was subsequently placed in a distinct genus, Gemella within the family Streptococcacea.[1],[2] It is a normal commensal organism found in the oral cavity and upper respiratory tract. It has been implicated in a variety of human infections like meningitis, septic arthritis, osteomyelitis, thoracic empyema with lung abscess, and endocarditis. [3] We report a case of endophthalmitis caused by G. haemolysans. We believe it is the first reported case of this rare species from ocular infection from our country.


  Case Report Top


A 60-year-old non-diabetic, hypertensive man was seen one day after onset of decreased vision associated with severe watering, eyelid swelling and pain. Symptoms had started four days (February 2009) after uneventful phacoemulsification with intraocular lens implantation surgery for age-related cataract in the left eye.

On examination, the left eye visual acuity was light perception with accurate projection of rays. Slit-lamp biomicroscopy of the pseudophakic eye showed lid edema, congested conjunctiva, microcystic corneal edema, no corneal infiltrates, 1.0 mm hypopyon, 3+ cells and flare in anterior chamber and fixed dilated pupil. [4] The intraocular pressure (IOP) was 31 mmHg done by applanation tonometry. Fundus examination showed vitreous exudates. On ocular ultrasonography, the retina appeared attached while low to medium reflective membranes with fine after-movements were noted in the vitreous cavity. Apparently the right eye examination was normal.

Acute pseudophakic postoperative endophthalmitis was diagnosed in the left eye. After informed consent, patient underwent a standard undiluted vitreous biopsy, pars plana vitrectomy and intraocular antibiotics were instilled; the antibiotics were vancomycin 1.0 mgm, ceftazidime 2.25 mg and dexamethasone 400 ΅gm. Postoperative topical medication included 3% ciprofloxacin and 1% prednisolone acetate eye drops every one hour, 1% homatropine eye drops four times a day and 0.5% timolol maleate eye drops and oral ciprofloxacin 750 mg twice a day.

The vitreous biopsy specimen was processed in the microbiology laboratory as per the institutional protocol. [5] Direct microscopic examination of vitreous sample revealed gram-positive cocci in pairs, short chains and tetrads. A confluent growth of gram-positive cocci with alpha haemolysis on blood agar was observed after 24 h of incubation. The organism was further identified as Gemella haemolysans using Mini API Rapid ID 32 Strep. The organism was sensitive to cefazolin, gentamicin, gatifloxacin, chloramphenicol, and vancomycin and resistant to amikacin, ciprofloxacin, ofloxacin and moxifloxacin.

On the eighth day, the antibiotic regimen was changed to 5% fortified cefazolin (10 ml of distilled water added to 500 ml cefazolin injection vial) eye drops one-hourly for three weeks and oral chloramphenicol 250 mg three times a day for a week. Four weeks after surgery his best corrected visual acuity improved to 20/80 N 12 and IOP was 16 mmHg. All medication was discontinued and topical steroids were tapered over next four weeks.


  Discussion Top


Gemella species were first isolated from the throat, nose, and eyes in measles patients by Tunicliff in 1917. [6] They are infrequently isolated from clinical specimens and are often confused with viridans-type streptococci. Identification is difficult. A literature search revealed only four reported cases of various eye infections caused by Gemella haemolysans.[7],[8],[9],[10]

Munir and Kailasanathan et al., reported Gemella haemolysans as a causative organism for infectious crystalline keratopathy. In both cases the organism was identified by automated systems API Rapid strep and complete resolution of the disease occurred with topical vancomycin therapy. The third case, reported by Ritterband et al., had a history of sarcoidosis and was on long-term systemic prednisolone. The patient developed bacterial keratitis and consecutive endophthalmitis. Surgical intervention with keratoplasty, pars plana vitrectomy, and intravitreal antibiotics led to resolution of the infection. The endophthalmitis case reported by Raman et al.,[10] was similar to our case of infection with a rare commensal organism in a healthy, immunocompetent individual. The postoperative cases, our case and the one reported by Raman et al., did not have any corneal involvement and presented with acute onset of vitreous exudates and hypopyon.

Gemella species are usually susceptible to a wide variety of antimicrobial agents including penicillin, ampicillin, rifampicin, and vancomycin but some isolates have demonstrated low-level resistance to aminoglycosides and trimethoprim. [11] Our isolate of Gemella spp. was susceptible to cefazolin, vancomycin, chloramphenicol, gatifloxacin and resistant to amikacin, ofloxacin and ciprofloxacin. There is only one case of vancomycin resistance reported in literature and our case showed good response to intravitreal vancomycin. [12] Postoperatively, our patient received topical and oral ciprofloxacin that was changed to topical fortified cefazolin and oral chloramphenicol, based on in vitro susceptibility tests. The patient showed rapid resolution of symptoms and signs of infection in follow-up. Kailasanathan et al., also observed rapid recovery in signs and symptoms after changing the antibiotics.

To conclude, as diagnostic technology improves, more and more rare organisms especially those that are commensal organisms or low-virulence organisms, will be identified as causing acute postoperative endophthalmitis. With good microbiological evaluation including drug sensitivity and timely intervention with appropriate medication results appear promising as seen in our case.

 
  References Top

1.
Kilpper-Balz R, Schleifer KH. Transfer of Streptococcus morbillorum to the genus Gemella as Gemella morbillorum comb.nov. Int J Syst Bacteriol 1988;38:442-3.  Back to cited text no. 1
    
2.
Whitney AM, O'Connor SP. Phylogenetic relationship of Gemella morbillorum to Gemella haemolysans. Int J Syst Bacteriol 1993;43:832-8.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.
Fresard A, Michael VP, Rueda X, Aubert G, Dorche G, Lucht F. Gemella haemolysans endocarditis. Clin Infect Dis 1993;16:586-7.  Back to cited text no. 3
    
4.
Perspectives- standardization of uveitis nomenclature for reporting clinical data results of the first international workshop. The standardization of uveitis nomenclature (SUN) working group. J Ophthalmol 2005;140:509-16.  Back to cited text no. 4
    
5.
Sharma S, Jalali S, Adiraju MR, Gopinathan U, Das TP. Sensitivity and predictability of vitreous cytology, biopsy and membrane filter culture in endophthalmitis. Retina 1996;16:525-9.  Back to cited text no. 5
    
6.
Tunicliff R. The cultivation of a micrococcus from blood in pre-eruptive stages of measles. JAMA 1917;68:1028-30.  Back to cited text no. 6
    
7.
Ritterband D, Shah M, Kresloff M, Intal M, Shabto U, Seedor J. Gemella haemolysan keratitis and consecutive endophthalmitis. Am J Ophthalmol 2002;133:268-9.  Back to cited text no. 7
[PUBMED]  [FULLTEXT]  
8.
Kailasanathan A, Anderson DF. Infectious crystalline keratopathy caused by Gemella haemolysans. Cornea 2007;26:643-4.  Back to cited text no. 8
[PUBMED]  [FULLTEXT]  
9.
Munir WM, Elmallah MK, Janda WM, Tu EY. Gemella haemolysans infectious crystalline keratopathy. Cornea 2006;25:1245-7.  Back to cited text no. 9
    
10.
Raman SV, Evans N, Freegard TJ, Cunningham R. Gemella haemolysans acute postoperative endophthalmitis. Br J Ophthalmol 2003;87:1192-3.   Back to cited text no. 10
[PUBMED]  [FULLTEXT]  
11.
Buu-Hoi A, Sapoetra A, Branger C, Acar JF. Antimicrobial susceptibility of Gemella haemolysans isolates from patients with subacute endocarditis. Eur J Clin Microbiol 1982;1:102-6.  Back to cited text no. 11
    
12.
Reed C, Efstratiou A, Morrison D, Woodford N. Glycopeptide-resistant Gemella haemolysans from blood. Lancet 1993;342:927-8.  Back to cited text no. 12
[PUBMED]  [FULLTEXT]  



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