|LETTER TO EDITOR
|Year : 2010 | Volume
| Issue : 3 | Page : 254-255
Vipul L Arora, Kim R Usha, Hadi M Khazei, Shivayogi Kusagur
Orbit, Oculoplasty and Oncology Clinic, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India
|Date of Web Publication||21-Apr-2010|
Kim R Usha
Orbit, Oculoplasty and Oncology Clinic, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Arora VL, Usha KR, Khazei HM, Kusagur S. Authors' reply. Indian J Ophthalmol 2010;58:254-5
The authors wish to thank Gonzalez-Granado  for his interest in our article  and for his comments.
- Regarding the etiology of the disease, we have mentioned about the chromosome 4q. , Further details of genetic mutations associated with this syndrome were not within the scope of this case report. The authors appreciate that this point was brought into focus.
- Patient was prescribed azithromycin after discussing it with the dermatologist. The patient had high serum IgE of 7375.2 IU/ml, there was a risk of further deterioration with sulpha drugs (cotrimoxazole) or pencillin group (cephalosporins), as these drugs are known to cause hypersensitivity reaction, which is an IgE-mediated response. Moreover, azithromycin has good activity against the staphylococcus group. 
- We agree that there is no other case report which suggests the association of Job's syndrome with retinal detachment. Therefore, we have mentioned in our case report that "we speculate that the etiology and pathogenesis of retinal detachment in case of Job's syndrome closely resembles with that of atopic dermatitis, which is an IgE-mediated hypersensitivity reaction" . This suggests that more studies are needed to prove this hypothesis.
| References|| |
Gonzalez- Garnado LI, Ophthalmic complications including retinal detachment in hyperimmunoglobulinemia E (Job's) syndrome: Case report and review of literature. Indian J Ophthalmol 2010;58:254.
Arora V, Kim UR, Khazei HM, Kusagur S. Ophthalmic complications including retinal detachment in hyperimmunoglobulinemia E (Job΄s) syndrome: Case report and review of literature. Indian J Ophthalmol 2009;57:385-6.
Paller AS. Genetic immunodeficiency diseases. In: Freedburg IM, Eisen AZ, Wolff K, Frank Austen K, Goldsmith LA, Katz SI, editors. Fitz Patrick's Dermatology in general medicine. 6 th
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Grimbacher B, Schδffer AA, Holland SM, Davis J, Gallin JI, Malech HL, et al
. Genetic linkage of hyper-IgE syndrome to chromosome 4. Am J Hum Genet 1999;65:735-44.
Williams JD. Spectrum of activity of azithromycin. Eur J Clin Microbiol Infect Dis 1991;10:813-20.