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Year : 2010  |  Volume : 58  |  Issue : 5  |  Page : 434-437

Voriconazole-refractory fungal infection of phacoemulsification tunnel

1 Sanjivni Eye Care, Model Town, Ambala, Haryana, India
2 Sharma Eye Hospital, Arya Chowk, Ambala, Haryana, India

Correspondence Address:
Vikas Mittal
Cornea Services, Sanjivni Eye Care, Model Town, Ambala City, Haryana-134 002
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0301-4738.67072

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A 44-year-old man presented 28 days after cataract surgery (phacoemulsification) in right eye with multiple pinpoint infiltrates in posterior stroma at cataract surgery wound site. Visual acuity was 20/60. Corneal scraping from the floor of the corneal tunnel revealed fungus which was later identified to be Aspergillus flavus. The patient was started on oral voriconazole 200 mg twice daily and topical voriconazole 1% every hour. Two intracameral injections of voriconazole (50 micrograms/ 0.1 ml) were given 72 h apart, five days after starting initial therapy. Infiltrates increased in size and density in spite of 20 days of voriconazole therapy. Full-thickness patch graft was done to arrest progressive necrosis. Four months after surgery, patient had 20/60 best-corrected visual acuity. There was no recurrence in one-year follow-up. Present case illustrates the therapeutic challenge in fungal tunnel infections and possibility of voriconazole-resistant Aspergillus species.

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