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LETTER TO EDITOR
Year : 2010  |  Volume : 58  |  Issue : 5  |  Page : 443-444

Autofluorescence findings and role of anti-vascular endothelial growth factor in inflammatory choroidal neovascular membrane


L V Prasad Eye Institute, Hyderabad, India

Date of Web Publication2-Aug-2010

Correspondence Address:
Jay Kumar Chhablani
Smt. Kanuri Santhamma Retina Vitreous Center, L V Prasad Eye Institute, Kallam Anji Reddy Campus, L V Prasad Marg, Banjara Hills, Hyderabad - 500 034, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.67041

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How to cite this article:
Chhablani JK. Autofluorescence findings and role of anti-vascular endothelial growth factor in inflammatory choroidal neovascular membrane. Indian J Ophthalmol 2010;58:443-4

How to cite this URL:
Chhablani JK. Autofluorescence findings and role of anti-vascular endothelial growth factor in inflammatory choroidal neovascular membrane. Indian J Ophthalmol [serial online] 2010 [cited 2015 Jun 30];58:443-4. Available from: http://www.ijo.in/text.asp?2010/58/5/443/67041

Dear Editor,

I read the article by Dhingra et al., [1] which describes the pathogenesis and treatment of the inflammatory choroidal neovascular membrane (CNVM). I would like to add a few comments about the autofluorescence (AF) findings and use of the anti-vascular endothelial growth factor (VEGF) in inflammatory CNVM.

Autofluorescence in Inflammatory CNVM

Many reports showed the utility of AF as a marker for early disease and in predicting the outcome of treatment in CNVM due to age-related macular degeneration. There are very few reports on AF findings in inflammatory CNVM.

Inflammatory CNVM, which is usually of the classic type (type 2), is seen on AF photography as a precise hyper-autofluorescent area due to the hyperplastic retinal pigment epithelium (RPE). Following treatment, CNVM may contract and leave a zone of absent RPE causing a hypo-autofluorescence.

Secondary choroidal neovascularization in multifocal choroiditis and panuveitis (MCP) is readily visible as a hyper-autofluorescencent area originating from a hypo-autofluorescent spot (scar). With increasing follow-up time, the hyper-autofluorescence associated with CNV decreases. AF imaging provides a method to image the appearance of new or enlarging spots that appear, which is more sensitive than using ophthalmoscopically visible signs.

More studies are required to understand the role of AF in inflammatory diseases. AF imaging could be an important noninvasive tool to reduce the need for angiography and to help in early diagnosis, as also in the follow-up of inflammatory CNVM patients.

Use of Anti Vegf0 in Inflammatory CNVM

There are potential disadvantages of treating inflammatory CNV with photodynamic therapy (PDT). PDT can cause localized inflammation and increase VEGF production. Local release of VEGF, after PDT, may be associated with a higher incidence of recurrent choroidal neovascularization (CNV). [2]

Tran et al studied 10 patients with CNV, who were refractory to previous immunosuppression and PDT or intravitreal triamcinolone (IVTA). They reported that intravitreal bevacizumab improved the best corrected visual acuity (BCVA) and reduced the central macular thickness in the eyes with 2.5 injections (mean), and this was seen at 7.5 months of follow up. In this study they included a patient who recurred three months after pegaptanib injection and responded well. [3] Fine et al reported successful treatment of inflammatory CNVM with ranibizumab in a patient with multifocal choroiditis and pan uveitis (MCP), who did not responded to bevacizumab or the PDT and IVTA therapy. [4]

The recent and largest case series by Monsour et al reported significant improvement of 2.2 lines in BCVA at 24 months, with a significant decrease in foveal thickness (265 microns), with only 1.3 injections (mean). This study confers the long-term benefits of intravitreal bevacizumab. [5]

Serious side effects and chances of recurrence make PDT an obsolete treatment option. Recent promising results favor intravitreal bevacizumab as a primary / mono therapy in inflammatory CNVM.

 
  References Top

1.
Dhingra N, Kelly S, Majid MA, Bailey CB, Dick AD. Inflammatory choroidal neovascular membrane in posterior uveitis-pathogenesis and treatment. Indian J Ophthalmol 2010;58:3-10.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Rogers AH, Martidis A, Greenberg PB, Puliafito CA. Optical coherence tomography findings following photodynamic therapy of choroidal neovascularization. Am J Ophthalmol 2002;134:566-76.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.
Tran TH, Fardeau C, Terrada C, Ducos De Lahitte G, Bodaghi B, Lehoang P. Intravitreal bevacizumab for refractory choroidal neovascularization (CNV) secondary to uveitis. Graefes Arch Clin Exp Ophthalmol 2008;246:1685-92.  Back to cited text no. 3
[PUBMED]  [FULLTEXT]  
4.
Fine HF, Zhitomirsky I, Freund KB, Barile GR, Shirkey BL, Samson CM, et al. Bevacizumab (avastin) and ranibizumab (lucentis) for choroidal neovascularization in multifocal choroiditis. Retina 2009;29:8-12.   Back to cited text no. 4
[PUBMED]  [FULLTEXT]  
5.
Mansour AM, Arevalo JF, Ziemssen F, Mehio-Sibai A, Mackensen F, Adan A, et al. Long-term visual outcomes of intravitreal bevacizumab in inflammatory ocular neovascularization. Am J Ophthalmol 2009;148:310-6.e2.  Back to cited text no. 5
    




 

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