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LETTER TO EDITOR
Year : 2010  |  Volume : 58  |  Issue : 6  |  Page : 549

Presentation of retinoblastoma in pregnancy


Ocular Oncology Service, L.V. Prasad Eye Institute, Road No 2, Banjara Hills, Hyderabad - 500 034, India

Date of Web Publication16-Oct-2010

Correspondence Address:
Santosh G Honavar
Ocular Oncology Service, L.V. Prasad Eye Institute, Road No 2, Banjara Hills, Hyderabad - 500 034
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.71682

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How to cite this article:
Ali MJ, Honavar SG. Presentation of retinoblastoma in pregnancy. Indian J Ophthalmol 2010;58:549

How to cite this URL:
Ali MJ, Honavar SG. Presentation of retinoblastoma in pregnancy. Indian J Ophthalmol [serial online] 2010 [cited 2020 Jun 2];58:549. Available from: http://www.ijo.in/text.asp?2010/58/6/549/71682

Dear Editor,

We read with interest the case report by Nandedkar et al. [1] We would like to articulate a few of our observations on this.

Fine needle aspiration cytology (FNAC) violates the established protocols in the diagnosis and management of retinoblastoma. [2] Recently, Eide et al., have reviewed the entire literature to date and have concluded that FNAC is a relatively strong contraindication in retinoblastoma owing to their poorly cohesive nature. [3] Karcioglu, in a well-controlled study, has histopathologically documented needle tract seeding in cases of retinoblastoma following FNAC. [4] Apart from the dreaded complication of tumor seeding, other possible complications such as vitreous hemorrhage can further preclude tumor assessment. [3]

Advanced retinoblastoma includes International Classification of Intraocular Retinoblastoma Group E, extraocular extension, optic nerve extension, and those with high risk factors for systemic metastasis on histopathology of the enucleated eye. [5] The case reported by the authors fulfills these criteria. There is an established protocol for managing advanced retinoblastoma, which begins with high-dose neoadjuvant chemotherapy aimed to achieve clinical resolution of the optic nerve and/or extraocular component of retinoblastoma as determined by serial computed tomography (CT) scan or magnetic resonance imaging (MRI), followed by extended enucleation, external beam radiotherapy, and adjuvant high-dose chemotherapy for 12 cycles. [5] This protocol helps improve life salvage to over 90% in advanced retinoblastoma. The CT scan provided by the authors does show thickening of the optic nerve. Once there is clinically evident optic nerve or extraocular extension, the case cannot be classified as Group E, rather it then needs to be staged and appropriately managed. Groups A to E are applicable only to intraocular retinoblastoma. [2]

 
  References Top

1.
Nandedkar VS, Joshi RA, Kabra N, Deshpande NN. Presentation of retinoblastoma in pregnancy. Indian J Ophthalmol 2010;58:229-32.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Shields JA, Shields CL. Retinoblastoma: Diagnostic approaches. In: Intraocular tumors - an atlas and textbook. In: Shields JA, Shields CL, editors. 2nd ed. Philadelphia: LWW; 2008. p. 319-25.  Back to cited text no. 2
    
3.
Eide N, Walaas L. Fine needle aspiration biopsy and other biopsies in suspected intraocular malignant disease: A review. Acta Ophthalmol 2009;83:588-601.  Back to cited text no. 3
    
4.
Karcioglu ZA, Gordon RA, Karcioglu GL. Tumor seeding in ocular fine needle aspiration biopsy. Ophthalmology 1985;92:1763-7.  Back to cited text no. 4
[PUBMED]    
5.
Honavar SG, Singh AD. Management of advanced retinoblastoma. Ophthalmol Clin North Am 2005;18:65-73.  Back to cited text no. 5
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1 Authorsę reply
Nandedkar, V., Joshi, A.R., Kabra, N., Deshpande, N.N.
Indian Journal of Ophthalmology. 2010; 58(6): 549
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