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BRIEF COMMUNICATION
Year : 2012  |  Volume : 60  |  Issue : 3  |  Page : 229-231

Intravitreal bevacizumab for treatment of choroidal neovascularization associated with osteogenesis imperfecta


Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, 18, College Road, Chennai, India

Correspondence Address:
Pukhraj Rishi
Sankara Nethralaya, 18, College Road, Chennai - 600006
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.95882

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A 12-year-old girl, diagnosed of osteogenesis imperfecta, presented with sudden visual loss in the left eye. Investigations revealed an active choroidal neovascular membrane. She underwent treatment with intravitreal Bevacizumab (1.25 mg/0.05 ml). Follow-up at 1 month revealed the development of lacquer crack running through the macula, underlying the fovea. The patient received two re-treatments at 1-month intervals, following which the choroidal neovascularization (CNV) regressed completely. However, further progression of lacquer cracks was noted. At the last follow-up, 6 months following the last injection, the fundus remained stable and vision was maintained at 20/200. Considering the natural history of the disease and the increased risk of rupture of the Bruch's membrane in such eyes, the possible complication of a lacquer crack developing must be borne in mind, before initiating treatment.


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