| BRIEF COMMUNICATION |
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| Year : 2012 | Volume
: 60
| Issue : 3 | Page : 229-231 |
Intravitreal bevacizumab for treatment of choroidal neovascularization associated with osteogenesis imperfecta
Pukhraj Rishi, Ekta Rishi, Anusha Venkatraman
Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, 18, College Road, Chennai, India
Correspondence Address:
Pukhraj Rishi
Sankara Nethralaya, 18, College Road, Chennai - 600006
India
DOI: 10.4103/0301-4738.95882
A 12-year-old girl, diagnosed of osteogenesis imperfecta, presented with sudden visual loss in the left eye. Investigations revealed an active choroidal neovascular membrane. She underwent treatment with intravitreal Bevacizumab (1.25 mg/0.05 ml). Follow-up at 1 month revealed the development of lacquer crack running through the macula, underlying the fovea. The patient received two re-treatments at 1-month intervals, following which the choroidal neovascularization (CNV) regressed completely. However, further progression of lacquer cracks was noted. At the last follow-up, 6 months following the last injection, the fundus remained stable and vision was maintained at 20/200. Considering the natural history of the disease and the increased risk of rupture of the Bruch's membrane in such eyes, the possible complication of a lacquer crack developing must be borne in mind, before initiating treatment.
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