|LETTER TO THE EDITOR
|Year : 2013 | Volume
| Issue : 11 | Page : 685
The neutrophil lymphocyte ratio may be useful inflammatory indicator before applying other expensive and invasive procedures
Sait Demirkol1, Sevket Balta1, Ugur Kucuk1, Hilal Olgun Kucuk2, Omer Kurt3, Hakan Sarlak3
1 Department of Cardiology, Gulhane Medical Academy Ankara, Ankara, Turkey
2 Department of Cardiology, Van Education and Research Hospital, Van, Turkey
3 Department of Internal Medicine, Gulhane Medical Academy Ankara, Ankara, Turkey
|Date of Web Publication||16-Dec-2013|
Department of Cardiology, Gulhane School of Medicine, Tevfik Saglam St., 06018 Etlik-Ankara
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Demirkol S, Balta S, Kucuk U, Kucuk HO, Kurt O, Sarlak H. The neutrophil lymphocyte ratio may be useful inflammatory indicator before applying other expensive and invasive procedures. Indian J Ophthalmol 2013;61:685
|How to cite this URL:|
Demirkol S, Balta S, Kucuk U, Kucuk HO, Kurt O, Sarlak H. The neutrophil lymphocyte ratio may be useful inflammatory indicator before applying other expensive and invasive procedures. Indian J Ophthalmol [serial online] 2013 [cited 2020 May 28];61:685. Available from: http://www.ijo.in/text.asp?2013/61/11/685/123150
We read with interest article the entitled "Relation between platelet indices and branch retinal vein occlusion (BRVO) in hypertensive patients" by Onder et al. They aimed to evaluate MPV in BRVO. They reported that MPV was significantly higher in patients with BRVO. The ready availability of MPV measurements at no additional cost may encourage its wider use in clinical practice.
Retinal vein occlusion is the most common retinal vascular occlusive disorder and is usually associated with a variable amount of loss of vision. Generally, branch retinal vein occlusion (BRVO) tends to be considered as one disease which is not only incorrect, but also cause of most of the confusion on the subject. A complete blood count is a relatively routine, inexpensive, practical, and easy examination that supplies additional information. MPV is a widely used laboratory marker associated with platelet function based on inflammatory conditions and thrombosis.  Recently, increased levels of MPV were demonstrated in cerebrovascular disease, peripheral artery disease, stroke, malignancy, gastrointestinal diseases, atrial fibrillation,  all of that are associated endothelial dysfunction on the basis of inflammation.  The higher MPV values are mentioned to be a beneficial marker of higher thromboycte activity and have been found to be associated with inflammation in patients with thyroid and rheumatic diseases. Platelet parameters might be influenced by coronary risk factors including age, obesity, smoking, diabetes mellitus, hypertension, hyperlipidemia, metabolic syndrome, and deep vein thrombosis. Furthermore, MPV value was found to be also higher in chronic obstructive pulmonary disease and nonalcoholic hepatic disease patients compared with a control group. Therefore, it may be interesting if the authors  provided information about these conditions.
Finally, not only MPV, but also red cell distribution width, neutrophil lymphocyte (N/L) ratio,  plateletcrit, platelet lymphocyte (P/L) ratio, C-reactive protein (CRP), gamma-glutamyl transferase (GGT), and uric acid are easy methods to evaluate the BRVO in hypertensive patients. These markers might be useful in clinical practice. We suggest that MPV ought to be evaluated together with other serum inflammatory markers such as N/L ratio, P/L ratio, GGT and uric acid.
| References|| |
Onder HI, Kilic AC, Kaya M, Bulur S, Onder E, Tunc M. Relation between platelet indices and branch retinal vein occlusion in hypertensive patients. Indian J Ophthalmol 2013;61:160-2.
Balta S, Demirkol S, Celik T, Kucuk U, Unlu M, Arslan Z, et al.
Association between coronary artery ectasia and neutrophil-Lymphocyte ratio. Angiology 2013;64:627-32.
Balta S, Demirkol S, Kucuk U, Unlu M. Hemostatic markers can be pivotal roles of risk factors for new-onset atrial fibrillation. Platelets 2013. [In press].
Demirkol S, Balta S, Unlu M, Yuksel UC, Celik T, Arslan Z, et al.
Evaluation of the mean platelet volume in patients with cardiac syndrome X. Clinics (São Paulo) 2012;67:1019-22.
Cingoz F, Iyisoy A, Demirkol S, Sahin MA, Balta S, Celik T, et al.
Carotid intima-media thickness in patients with slow coronary flow and its association with neutrophil-to-lymphocyte ratio: A preliminary report. Clin Appl Thromb Hemost 2013. [In press].