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   Table of Contents      
LETTER TO THE EDITOR
Year : 2013  |  Volume : 61  |  Issue : 11  |  Page : 686-687

Mean platelet volume as a marker of branch retinal vein occlusion may be influenced by many factors


1 Department of Ophthalmology, Hakkari Military Hospital, Hakkari, Turkey
2 Department of Emergency, Hakkari Military Hospital, Hakkari, Turkey
3 Department of Ophthalmology, Adana Military Hospital, Adana, Turkey
4 Gülhane Medical School, Ankara, Turkey

Date of Web Publication16-Dec-2013

Correspondence Address:
Yakup Aksoy
Department of Ophthalmology, Hakkari Military Hospital, Hakkari
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.119414

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How to cite this article:
Aksoy Y, Eyi YE, Kar T, Sevinc MK. Mean platelet volume as a marker of branch retinal vein occlusion may be influenced by many factors. Indian J Ophthalmol 2013;61:686-7

How to cite this URL:
Aksoy Y, Eyi YE, Kar T, Sevinc MK. Mean platelet volume as a marker of branch retinal vein occlusion may be influenced by many factors. Indian J Ophthalmol [serial online] 2013 [cited 2019 Dec 8];61:686-7. Available from: http://www.ijo.in/text.asp?2013/61/11/686/119414

Dear Editor,

We read the article ''Relation between platelet indices and branch retinal vein occlusion in hypertensive patients" written by Onder et al., [1] with interest. They aimed in this well-designed study to find the relation between branch retinal vein occlusion (BRVO) and mean platelet volume (MPV) in hypertensive patients. They concluded that MPV was significantly higher in hypertensive BRVO patients and it's potentially use as a prognostic biomarker in patients with BRVO would be possible in the future. We congratulate the authors for their lightening study. We would like to inform an error which we think to be done by mistake and make some contributions about study.

BRVO is one of the most common retinal vascular occlusive disorders and is usually associated with vitreous hemorrhage and a variable amount of vision loss. [2],[3] It has been suggested in the literature that arteriosclerosis and arteriovenous crossing of retinal branch vessels play important roles in development of BRVO. [2] MPV is a marker of platelet size and activation. Increased MPV reflects active and large platelets. MPV is one of the most widely used laboratory markers to be related the platelet function and based on inflammatory condition. [4]

In present study, the authors reported that exclusion criteria included history of diabetes, glaucoma, blood dyscrasias, renal failure, hepatic disorders, malignancy, and history of drug use (nonsteroid anti-inflammatory drugs, anticoagulant medications, and oral contraceptives). Patients with BRVO who had a history of vasculitis were also excluded. But in the literature, much more factors were reported which influence MPV level. Some of these factors are obesity, smoking and duration of it, metabolic syndrome, thyroid diseases, nasal polyposis, and bone mineral density. Especially the high-grade inflammatory diseases, such as active rheumatoid arthritis, familial  Mediterranean fever More Details, acute pancreatitis, Crohn's disease, and ankylosing spondylitis influence MPV level too. [4],[5] In this study, the authors informed about number of smoking patients but did not mention about duration of smoking and difference between study groups. We think that if the authors gave information about these factors influencing MPV, the results of the present study may be different and stronger.

We also want to inform an error which we think to be done by mistake. The authors reported in results that the platelet count was lower in the control group but the difference did not reach a statistically significant level. But inversely they reported in discussion part that the platelet count was insignificantly decreased in the BRVO group. We think that the second one was right and this was shown in [Table 2].

 
  References Top

1.
Onder HI, Kilic AC, Kaya M, Bulur S, Onder E, Tunc M. Relation between platelet indices and branch retinal vein occlusion in hypertensive patients. Indian J Ophthalmol 2013;61:160-2.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Hayreh SS. Retinal vein occlusion. Indian J Ophthalmol 1994;42:109-32.  Back to cited text no. 2
[PUBMED]  Medknow Journal  
3.
Saxena S, Jalali S, Verma L, Pathengay A. Management of vitreous haemorrhage. Indian J Ophthalmol 2003;51:189-96.  Back to cited text no. 3
[PUBMED]  Medknow Journal  
4.
Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Curr Pharm Des 2011;17:47-58.  Back to cited text no. 4
[PUBMED]    
5.
Li XS, Zhang JR, Meng SY, Li Y, Wang RT. Mean platelet volume is negatively associated with bone mineral density in postmenopausal women. J Bone Miner Metab 2012;30:660-5.  Back to cited text no. 5
[PUBMED]    




 

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