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   Table of Contents      
Year : 2013  |  Volume : 61  |  Issue : 11  |  Page : 692

Platelet indices in retinal vein occlusion in hypertensive patients

Department of Cardiology, Faculty of Medicine, Suleyman Demirel Univesitesi Tęp Fakultesi, Isparta, Turkey

Date of Web Publication16-Dec-2013

Correspondence Address:
Ercan Varol
Department of Cardiology, Faculty of Medicine, Suleyman Demirel Univesitesi Tęp Fakultesi, Isparta
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0301-4738.121136

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How to cite this article:
Varol E, Ozaydin M. Platelet indices in retinal vein occlusion in hypertensive patients. Indian J Ophthalmol 2013;61:692

How to cite this URL:
Varol E, Ozaydin M. Platelet indices in retinal vein occlusion in hypertensive patients. Indian J Ophthalmol [serial online] 2013 [cited 2020 May 30];61:692. Available from: http://www.ijo.in/text.asp?2013/61/11/692/121136


We read the article by Onder et al. with great interest. [1] The authors measured the mean platelet volume (MPV) in hypertensive patients with branch retinal vein occlusions (BRVO). They found that hypertensive patients with BRVO have significantly higher MPV than controls, suggesting higher platelet activity. This is an interesting study. However, we want to make some minor criticisms about this study.

In generally method of MPV assessing is correct. They studied the blood samples within 2 h to prevent ethylenediaminetetraacetic acid induced swelling. On the other hand, there are significant associations of MPV with diabetes mellitus, pre-diabetes, hypertension, hypercholesterolemia, obesity, metabolic syndrome, smoking, statin and some antihypertensive drug use and atrial fibrillation. [2],[3] These factors can influence the MPV values. Although the authors excluded some chronic diseases, data of cardiovascular diseases including coronary artery disease, body mass index, antihypertensive drugs and statin use is lacking. The mean age of the patients is 62-year-old and some of them may have cardiovascular disease at this age. It has also been shown that some antihypertensive drug and statin use can affect MPV values. [4],[5],[6] When we look at, nearly all patients and controls are hypertensive. However, there is no data about drugs used in these patients and controls. We believe that, it would be useful, if the authors provided data about these risk factors and their possible relationship with MPV and hypercholesterolemia.

In our previous study, we found that MPV was significantly elevated in patients with deep vein thrombosis compared with controls. [7] Platelet activation might occur with a similar mechanism in patients with BRVO and deep vein thrombosis. We think that patients with BRVO are under risk of other cardiovascular disorders and must be investigated from this aspect.

  References Top

Onder HI, Kilic AC, Kaya M, Bulur S, Onder E, Tunc M. Relation between platelet indices and branch retinal vein occlusion in hypertensive patients. Indian J Ophthalmol 2013;61:160-2.  Back to cited text no. 1
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Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2009;63:1509-15.  Back to cited text no. 2
Varol E, Akcay S, Icli A, Yucel H, Ozkan E, Erdogan D, et al. Mean platelet volume in patients with prehypertension and hypertension. Clin Hemorheol Microcirc 2010;45:67-72.  Back to cited text no. 3
Nadar S, Blann AD, Lip GY. Platelet morphology and plasma indices of platelet activation in essential hypertension: Effects of amlodipine-based antihypertensive therapy. Ann Med 2004;36:552-7.  Back to cited text no. 4
Bakovic D, Pivac N, Eterovic D, Palada I, Valic Z, Paukovic-Sekulic B, et al. Changes in platelet size and spleen volume in response to selective and non-selective beta-adrenoceptor blockade in hypertensive patients. Clin Exp Pharmacol Physiol 2009;36:441-6.  Back to cited text no. 5
Coban E, Afacan B. The effect of rosuvastatin treatment on the mean platelet volume in patients with uncontrolled primary dyslipidemia with hypolipidemic diet treatment. Platelets 2008;19:111-4.  Back to cited text no. 6
Gulcan M, Varol E, Etli M, Aksoy F, Kayan M. Mean platelet volume is increased in patients with deep vein thrombosis. Clin Appl Thromb Hemost 2012;18:427-30.  Back to cited text no. 7


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