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BRIEF COMMUNICATION
Year : 2013  |  Volume : 61  |  Issue : 6  |  Page : 303-304

Serpiginous choroiditis and acute retinal necrosis occurring in the same patient


1 Department of Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India
2 Department of Uveitis and Ocular Pathology, Sankara Nethralaya, Chennai, Tamil Nadu, India

Date of Submission22-Apr-2011
Date of Acceptance22-Jan-2012
Date of Web Publication27-Jun-2013

Correspondence Address:
Aditi Gupta
Department of Vitreoretinal Services, Sankara Nethralaya, 18, College Road, Chennai-600006, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.99991

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  Abstract 

We describe a rare association of serpiginous choroiditis with necrotizing retinitis having clinical features of acute retinal necrosis (ARN). A 23-year-old male developed ARN in the fellow eye while he was on tapering doses of immunosuppressive medications for unilateral serpiginous choroiditis. The association may represent a common viral etiology of the two diseases or may be due to the development of ARN due to general state of iatrogenic immunosuppression. This report also highlights the importance of a detailed evaluation of both the eyes on regular follow-up visits in the patients receiving iatrogenic immunosuppression.

Keywords: Acute retinal necrosis, immunosuppression, serpiginous choroiditis


How to cite this article:
Gupta A, Biswas J. Serpiginous choroiditis and acute retinal necrosis occurring in the same patient. Indian J Ophthalmol 2013;61:303-4

How to cite this URL:
Gupta A, Biswas J. Serpiginous choroiditis and acute retinal necrosis occurring in the same patient. Indian J Ophthalmol [serial online] 2013 [cited 2019 Oct 19];61:303-4. Available from: http://www.ijo.in/text.asp?2013/61/6/303/99991

Serpiginous choroiditis is rare inflammation of the retinal pigment epithelium and choroid; the macular form being well-recognized. [1] The etiology remains unknown despite various studies implicating infectious agents including viral etiology in the pathogenesis. [2],[3]

Acute retinal necrosis (ARN) has established viral etiology and is characterized by presence of peripheral retinal necrosis with retinal arteritis and prominent vitritis in immunocompetent patients. [4] However, the disease has been reported to occur in immunosuppressed patients, including iatrogenic immunosuppression. [5],[6] The diagnosis of ARN is usually based on clinical findings. [4]

We report a patient with unilateral serpiginous choroiditis who developed necrotizing retinitis with clinical features of acute retinal necrosis in the fellow eye.


  Case Report Top


A 23-year-old male presented with the complaint of decreased vision in the right eye since 3 months. He had been treated elsewhere for right eye choroiditis with intravenous methyl prednisone acetate (IVMP) 1 g/day for 3 days followed by oral steroids and Tab Azathioprine. At presentation, he was taking Tab Prednisone 50 mg/day and Tab Azathioprine 125 mg/day. Best corrected visual acuities (BCVA) were 20/200 and 20/20 in the right and left eyes, respectively. Left eye was essentially normal on examination. Right eye revealed quiet anterior chamber and quiet vitreous cavity with a yellowish area of active choroiditis with geographic borders involving the macula in serpiginous pattern. Fundus fluorescein angiography confirmed the findings. He was diagnosed as a case of active macular serpiginous choroiditis. After obtaining physician's clearance, we prescribed Tab Prednisone 60 mg/day (1 mg/kg body weight), Tab Azathioprine 50 mg thrice a day, Tab Cyclosporine 150 mg twice a day, with antacid and calcium supplements. QuantiFERON-TB Gold test was found to be negative. On regular follow-up visits, the choroiditis lesions were noted to heal over a period of 3 months, and treatment was gradually tapered.

After 3 months, patient complained of redness, pain and blurring of vision in the left eye. At this point of time, he was on Tab Prednisone 7.5 mg/day, Tab Azathioprine 50 mg/day and Tab Cyclosporine 200 mg/day. BCVA were 20/400 and 20/20 partial in the right and left eyes, respectively. Right eye examination revealed a quiet eye with healed lesions of macular serpiginous choroiditis [Figure 1]. Left eye had 2+ anterior chamber cells, severe vitritis, and an area of retinal whitening suggestive of necrotizing retinitis in the inferonasal periphery. A clinical diagnosis of acute retinal necrosis was made. Tab Cyclosporine and Tab Azathioprine were stopped, Tab Prednisone was hiked to 60 mg/day, and intravenous Aciclovir 500 mg thrice a day was started under monitoring. Serum ELISA for Human immunodeficiency virus (HIV) was negative. On regular examinations, vitreous haze decreased markedly and the lesion showed signs of healing [Figure 2]. After 1 week, intravenous Aciclovir was stopped and the patient was prescribed Tab Valaciclovir 1 g thrice a day, and Tab Prednisone to be tapered at 10 mg/week. As on last visit after 2 months, anterior chamber was quiet and retinitis had resolved significantly. The patient is under regular follow-up.
Figure 1: Color fundus photograph of the right eye showing the healed lesions of macular serpiginous choroiditis

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Figure 2: Color fundus photograph of the left eye showing presence of vitreous haze with white lesion of necrotizing retinitis (acute retinal necrosis) in the inferonasal periphery

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  Discussion Top


We report a patient who developed ARN in the fellow eye while he was on tapering doses of immunosuppressive medications for unilateral serpiginous choroiditis. To the author's knowledge, the association of serpigenous choroiditis with ARN has not been reported earlier. This association can be explained by two possibilities; it may represent a common viral etiology of the two diseases or development of ARN due to general state of iatrogenic immunosuppression.

The viral etiology for serpiginous choroiditis is not yet firmly established. [2],[3] Gass et al. reported a case of serpiginous choroiditis following herpes zoster ophthalmicus and suggested a possible viral etiology in some patients with serpiginous chorioditis. [7] Priya et al. suggested that herpes viruses might have a role in the pathogenesis of the disease in a subset of patients with serpiginous choroiditis. [2] Erkkilä et al. reported increased levels of antiviral (herpes simplex) antibodies in serum of two patients with serpigenous choroiditis. [3] Ampigenous choroiditis, a variant of serpiginous choroiditis, has been reported to occur following quadrivalent human papilloma virus vaccine. [8] The treatment of serpiginous choroiditis with systemic antivirals has been recommended and practiced by some authors. [9],[10] In our case, the limitation is the lack of serological diagnosis to prove a common herpetic origin of the serpiginous choroiditis in the right eye and necrotizing retinitis in the left eye. However, most immunologic explanations of serpiginous choroiditis deal with hypersensitivity reactions and virus would not need to be present in the eye in order to explain the disease. Likewise, though anterior chamber biopsy with polymerase chain reaction (PCR) testing for herpes virus would have strongly confirmed the diagnosis of ARN in the left eye, ARN is a clinical diagnosis and has an established viral etiology. [4]

The other possibility can be the development of ARN due to iatrogenic immunosuppression. ARN has been reported to occur in immunosuppressed patients, including iatrogenic immunosuppression [5] and following intravitreal steroid injections. [6] Though our patient was not found to have an HIV infection, he had received a course of IVMP elsewhere and was on immunosuppressive medications for almost 9 months when he developed ARN.

The temporal relationship between serpiginous choroiditis and ARN, reported in the present case, is intriguing. Our case report also highlights the importance of a detailed evaluation of both the eyes on regular follow-up visits in the patients receiving iatrogenic immunosuppression.

 
  References Top

1.
Sahu DK, Rawoof A, Sujatha B. Macular serpiginous choroiditis. Indian J Ophthalmol 2002;50:189-96.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Priya K, Madhavan HN, Reiser BJ, Biswas J, Saptagirish R, Narayana KM, et al. Association of herpes viruses in the aqueous humor of patients with serpiginous choroiditis: A polymerase chain reaction-based study. Ocul Immunol Inflamm 2002;10:253-61.  Back to cited text no. 2
[PUBMED]    
3.
Erkkilä H, Laatikainen L, Jokinen E. Immunological studies on serpiginous choroiditis. Graefes Arch Clin Exp Ophthalmol 1982;219:131-4.  Back to cited text no. 3
    
4.
Holland GN. Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society. Am J Ophthalmol 1994;117:663-7.  Back to cited text no. 4
[PUBMED]    
5.
Muthiah MN, Michaelides M, Child CS, Mitchell SM. Acute retinal necrosis: A national population-based study to assess the incidence, methods of diagnosis, treatment strategies and outcomes in the UK. Br J Ophthalmol 2007;91:1452-5.  Back to cited text no. 5
[PUBMED]    
6.
Shah AM, Oster SF, Freeman WR. Viral retinitis after intravitreal triamcinolone injection in patients with predisposing medical comorbidities. Am J Ophthalmol 2010;149:433-40.  Back to cited text no. 6
[PUBMED]    
7.
Gass JD. Stereoscopic Atlas of the Macular Diseases. Diagnosis and Treatment. 4 th ed., vol. 1. St. Louis: Mosby; 1997. p. 49-286.  Back to cited text no. 7
    
8.
Khalifa YM, Monahan PM, Acharya NR. Ampiginous choroiditis following quadrivalent human papilloma virus vaccine. Br J Ophthalmol 2010;94:137-9.  Back to cited text no. 8
[PUBMED]    
9.
Christmas NJ, Oh KT, Oh DM, Folk JC. Long-term follow-up of patients with serpigenous choroiditis. Retina 2002;22:550-6.  Back to cited text no. 9
    
10.
Araujo AA, Wells AP, Dick AD, Forrester JV. Early treatment with cyclosporin in serpiginous choroidopathy maintains remission and good visual outcome. Br J Ophthalmol 2000;84:979-82.  Back to cited text no. 10
[PUBMED]    


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