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BRIEF COMMUNICATION
Year : 2013  |  Volume : 61  |  Issue : 9  |  Page : 525-527

Comparison of efficiency of intravitreal ceftazidime and intravitreal cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis


1 Department of Ophthalmology, Batman State Hospital, Batman, Turkey
2 Department of Ophthalmology, School of Medicine, Firat University, Elazig, Turkey
3 Adiyaman University, Adiyaman, Turkey
4 Department of Pathology, School of Medicine, Inönü University, Malatya, Turkey
5 Department of Microbiology, School of Medicine, Firat University, Elazig, Turkey

Correspondence Address:
Orhan Aydemir
Department of Ophthalmology, School of Medicine, Firat University, 23119 Elazig
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.119457

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In this study, we evaluated the efficiency of cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis. We compared the findings with the standard dose of ceftazidime (1 mg/0.1 ml). Thirty-six New-Zealand White rabbits were divided into 6 equal groups and were treated with different methods (Group 1 = sham, Group 2 = 0.5 mg/0.1 ml cefepime, Group 3 = 1 mg/0.1 ml cefepime, Group 4 = 2 mg/0.1 ml cefepime, Group 5 = 1 mg/0.1 ml ceftazidime, Group 6 = control). The eyes of rabbits in each group were examined clinically on 1 st , 3 rd , and 6 th day of the experiment. At 6 th day, 0.1 ml vitreous humor aspirates were obtained and plated for quantification on the blood agar and the results were expressed as colony-forming unit/ml. Subsequently, the eyeballs were enucleated and the histopathological evaluation was performed. Our findings denoted beneficial effects of cefepime in treatment groups (especially, in Groups 3 and 4). Intravitreal cefepime may be an alternative drug in the treatment of P. aeruginosa endophthalmitis.


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