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Brachytherapy of intra ocular tumors using 'BARC I-125 Ocu-Prosta seeds': An Indian experience
Vikas Khetan1, Lingam Gopal2, Mahesh P Shanmugam3, Aditi Gupta1, Tarun Sharma1, Pramod Bhende1, Siva Muthukumar4, R Subramaniam5, Thayalan Kuppuswamy6, SK Saxena7, Ashutosh Dash7
1 Department of Ocular Oncology and Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India
2 Department of Ocular Oncology and Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India; Department of Ophthalmology, National University Hospital, Singapore
3 Department of Ocular Oncology and Vitreoretinal Services, Sankara Eye Hospitals, Bangalore, Karnataka, India
4 Chief Medical Physicist, Dr. Rai Memorial Cancer Institute, Chennai, Tamil Nadu, India
5 Consultant Radiation Oncologist, Dr. Rai Memorial Cancer Institute, Chennai, Tamil Nadu, India
6 Consultant Medical Physicist, Dr. Kamakshi Memorial Hospital, Chennai, Tamil Nadu, India
7 Radiopharmaceuticals Division, Bhabha Atomic Research Center, Mumbai, Maharashtra, India
Correspondence Address:
Vikas Khetan
Department of Ocular Oncology and Vitreoretina, Sankara Nethralaya, 18, College Road, Chennai - 600 006, Tamil Nadu, India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0301-4738.128618
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Aim: To report our experience of brachytherapy using 'BARC I-125 Ocu-Prosta seeds' for the management of intraocular tumors with regard to tumor control, globe preservation visual outcome, and patient survival at Sankara Nethralaya, Chennai, India between September 2003 and May 2011. Materials and Methods: We reviewed records of 35 eyes of 35 patients who underwent ophthalmic brachytherapy between September 2003 and May 2011. Twenty-one cases had choroidal melanoma, nine had childhood retinoblastoma, two had adult-onset retinoblastoma, and there were one case each of vasoproliferative tumor, retinal angioma, and ciliary body melanoma. Brachytherapy was administered using a 15- or 20-mm gold plaque with or without a notch. Brachytherapy was the primary treatment modality in all tumors other than retinoblastoma, wherein brachytherapy was done post chemoreduction for residual tumor. Results: For choroidal melanomas, the mean radiation dose was 68.69 ± 15.07 (range, 47.72-94.2) Gy. The eye salvage rate was 13/20 (65%) and tumor control rate was 16/20 (80%) at an average follow-up of 24.43 ± 24.75 (range, 1.5-87.98) months. For retinoblastoma, the mean dose was 45.85 ± 3.90 (range, 39.51-50.92) Gy. The eye salvage rate and tumor control rate was 5/6 (83.3%) at an average follow-up of 38.36 ± 31.33 (range, 4.14-97.78) months. All eyes with retinoblastoma needed additional focal therapy for tumor control and eye salvage. Conclusion: The results of this retrospective study confirms that the use of 'BARC I-125 Ocu-Prosta seeds' in episcleral plaques to treat intraocular tumors offers a viable option for the management of intraocular cancers. |
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