Glyxambi
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 5836
  • Home
  • Print this page
  • Email this page


 
   Table of Contents      
ORIGINAL ARTICLE
Year : 2014  |  Volume : 62  |  Issue : 2  |  Page : 167-170

Role of echography in diagnostic dilemma in choroidal masses


1 LVPEI, Hyderabad, India
2 Ultrasound and Retina Department, M&J Institute, Ophthalmology, Ahmedabad, Gujarat, India

Date of Submission11-Aug-2012
Date of Acceptance16-Sep-2013
Date of Web Publication11-Mar-2014

Correspondence Address:
Hansa H Thakkar
Ultrasound and Retina Department, M&J Institute of Ophthalmology, Ahmedabad, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.128626

Rights and Permissions
  Abstract 

Purpose: To evaluate the role of echography in diagnosis and management of a diverse array of choroidal masses. Materials and Methods: Sixty-two cases of clinically suspected choroidal masses were prospectively analyzed with B-scan (10 Hz), A-scan, and ultrasound biomicroscopy (UBM) (50 Hz) after a meticulous history and ocular examination. Ancillary investigations and systemic evaluation were also done. Results: Based on clinical suspicion, acoustic features, response to treatment, and other ancillary tests combined together, the various masses were differentiated. The cases included in the study were as follows: n = 10 malignant melanomas, n = 16 metastasis and infiltrations, n = 9 hemangioma, n = 7 tuberculoma, n = 8 nonspecific inflammatory masses, n = 2 disciform plaques, n = 4 macular cysts or retinoschisis, n = 2 Coat's disease, n = 1 melanocytoma, and n = 2 osteomas. Ultrasonography (USG) alone could identify n = 51 lesions, while UBM in combination with USG was needed in remaining 11 masses. Conclusion: Standardized echography is an important adjunct in the diagnosis and management of eyes with intraocular masses. A better understanding of the clinicopathological and echographic picture of the diverse lesions can help in detection, differentiation, diagnosis, proposing a therapeutic approach, and also monitoring response to treatment. Echography is essential to evaluate tumors for extrascleral and anterior segment extension.

Keywords: Acoustic features, A-scan, B-scan, choroidal mass, ultrasound biomicroscopy


How to cite this article:
Mithal KN, Thakkar HH, Tyagi MA, Bharwada RM, Billore PO. Role of echography in diagnostic dilemma in choroidal masses. Indian J Ophthalmol 2014;62:167-70

How to cite this URL:
Mithal KN, Thakkar HH, Tyagi MA, Bharwada RM, Billore PO. Role of echography in diagnostic dilemma in choroidal masses. Indian J Ophthalmol [serial online] 2014 [cited 2019 Sep 23];62:167-70. Available from: http://www.ijo.in/text.asp?2014/62/2/167/128626

Choroidal masses present with a diverse array of clinical features ranging from life-threatening malignant melanomas and metastatic deposits to an innocuous nevus. They more often than not become a diagnostic dilemma for the clinician. The fight against pseudomelanomas, i.e. masses simulating the deadly malignant melanoma, was started by the pioneers in the field like Jerry A. Shields and Zimmerman. In the last three decades, the rate of misdiagnosis and enucleation for choroidal melanomas has been brought down from 20% to less than 1%, but this fight still continues. Many early treatable lesions go undiscovered or wrongly diagnosed, many salvageable eyes are lost, and many lives are lost because of mostly lack of experience in the field and unavailability of affordable imaging modalities. In recent years, ophthalmic ultrasound comprising B-scan (10 MHz), A-scan, and ultrasound biomicroscopy (UBM) (50 MHz) has become a useful, rather indispensable tool for management of such intraocular masses and tumors. Apart from cases with opaque media, echography is also used as an adjunct to clinical examination in the detection, differentiation, measurement of accurate dimensions, monitoring growth, looking for extra orbital extension, and monitoring regression in response to treatment. [1] It is cost-effective, noninvasive, and reproducible, which are important considerations, especially in rural settings. [2] It has been shown to have greater than 95% accuracy [3] in differentiating choroidal melanomas from other eye lesions.


  Materials and Methods Top


A prospective analysis of 62 cases of choroidal masses was done between September 2007 and August 2009. Most cases were referred to us from peripheral centers as suspected posterior segment masses, while a few had already been treated as common conditions such as retinal detachment, and glaucoma and came to us in advanced stages.

On presentation, a thorough history taking and clinical examination were carried out. Indirect ophthalmoscopy was done followed by echographic evaluation with B-scan (10 MHz) and A-scan by a single examiner. UBM evaluation (50 MHz) was done when ciliary body and iris involvement were suspected. The various acoustic features studied were as follows: anatomical location, extent, approximate dimensions, shape, internal reflectivity, echogenicity, acoustic hollowing, choroidal excavation, hemorrhage, calcification, retinal detachment, scleral or extrascleral extension, and involvement of iris and/or ciliary body. [4] Ancillary investigations were ordered when needed. Expert opinions were taken from oncology, chest and tuberculosis, neurosurgery, and pediatric departments. These in collaboration with clinical features and proposed clinical judgment helped us frame a diagnosis. Inflammatory, tuberculous, and other benign lesions were managed conservatively with specific or nonspecific therapy, and response to treatment was monitored with echography which confirmed the diagnosis at times. Malignant conditions were referred to the oncology department for further management and response to treatment was monitored with echography. The cases treated surgically were confirmed by histopathology.


  Results Top


In our study, we enrolled 62 cases of choroidal masses comprising n = 10 malignant melanomas (16.1%), n = 16 metastasis and infiltrations (25.8%), n = 9 hemangiomas (14.5%), n = 7 tuberculoma (11.2%), n = 8 inflammatory masses (12.9%), n = 2 disciform plaques (3%), n = 4 macular cysts or retinoschisis (6%), n = 2 Coat's disease (3%), n = 1 melanocytoma (1.5%), n = 1 nevus (1.5%), and n = 2 osteomas (3%) [Figure 1].
Figure 1: Types of the choroidal lesions

Click here to view


Ultrasonography (USG) alone could identify 51 lesions, while UBM in combination with USG was needed in remaining 11 masses. Bilateral involvement was seen in six cases which comprised two leukemic infiltrates, one metastasis, two hemangiomas, and one disciform scar. The more severely affected eye was included in the study.

Forty-one eyes had mass limited to choroidal tissue behind the equator (66.1%), 6 eyes had diffuse involvement of the choroidal tissue (9.6%), 4 masses filled the whole posterior segment (6.4%), and rest 11 had involvement of iris or ciliary body in addition to choroidal tissue (17.74%). [Figure 2] shows few classical configurations seen in lesions under study. The main echographic features found in the 62 choroidal masses in our study on echography are briefly described in [Table 1].
Table 1: Types of choroidal lesions

Click here to view
Figure 2: Classical configurations of choroidal lesions (a) Mushroom shaped melanoma (b) Dome shaped haemangioma (c) Bullous choroidal detachment (d) Diffuse tuberculoma

Click here to view


A total of 41% cases had hazy media, while 72% cases had associated retinal or choroidal detachments. The various features of the lesion or conditions of affected eye which made echography useful and often essential in our evaluation have been described in [Table 2]. Few interesting and classical cases included in our study have been showed in [Figure 3], [Figure 4], [Figure 5], [Figure 6].
Table 2: Indications for echography in choroidal lesions

Click here to view
Figure 3: Malignant melanoma of choroid (a) Fundus photo of large posterior pole melanoma (b) Multiple pin point leaks on FFA (c) Mushroom sharped mass on B-scan (d) Low to moderate internal echoes on A-san

Click here to view
Figure 4: Melanocytoma over optic nerve head. (a) Fundus photo posterior pole melanocytoma (b) Blocked fluorescence with fimbriated margins (c) Nodular mass on B-scan (d) High internal echoes on A-scan

Click here to view
Figure 5: Metastatic choroidal deposit from carcinoma breast (a) Metastatic deposit from breast carcinoma (b) Retinal datachment (c) Flat topped posterior pole metastatic deposits (d) Moderate to high internal reflectivity on A-scan

Click here to view
Figure 6: Choroidal osteoma (a) Yellowish orange macular Choroidal Osteoma (b) Posterior pole calcified plaque (c) High echoes on lowest gain on A-scan

Click here to view



  Discussion Top


The echographic profile of the various choroidal masses we studied closely matched the features described by various sources, not withstanding a few variations. [1],[5],[6],[7]

A 14-year retrospective evaluation of choroidal masses done at Chang Gung Memorial Hospital, Taiwan, showed a closely resembling profile of 46 patients (51 eyes) including 12 cases (26%) of metastatic deposits, 10 cases (22%) of hemangiomas, 2 cases (4%) of osteomas, 5 cases (11%) of melanocytoma, 8 cases (17%) of malignant melanomas, and 9 cases (20%) of other melanocytic lesions.

Jerry A Shields has summarized 25 years experience of differentiating melanomas from lesions simulating them and showed that 14% of suspected posterior uveal melanomas were pseudomelanomas consisting of naevi, hemangiomas, choroidal effusions, age-related macular degeneration (ARMD), etc. [8]

While most studies on choroidal tumors have been done in the west, data from our subcontinent are very little. Unlike the usual belief, melanomas are commonly seen in the Indian subcontinent. Nonspecific and specific inflammatory masses like tuberculoma which are rather rare in the literature are seen more commonly and exclusively in our country.

While the western literature claims that one hemangioma is seen per 15-40 cases of melanomas, [9] we have come across a nearly equal number of hemangiomas as melanomas in our 2 years of study. The principles laid down by Dr. K.C. Ossoinig [1],[10] for diagnosing various posterior segment masses still hold true. We have used them as a guide in our diagnosis. The classical features seen in choroidal masses have been shown in [Table 3].
Table 3: Chief acoustic features of choroidal masses

Click here to view



  Conclusion Top


A better understanding of clinicopathological correlation combined with an early echography can diagnose the choroidal masses and hence can propose a timely therapeutic approach even in peripheral centers. Follow-up echography ascertains diagnosis and monitors the response to treatment modalities. The diagnostic dilemma in cases of suspicious choroidal masses can be majorly resolved with a judicious echography reducing the incidence of erroneous diagnosis. Echography helps in reduction of morbidity and mortality due to late or wrong diagnosis of malignant melanomas and other lesions.

 
  References Top

1.
Ossoing KC. Preoperative differential diagnosis of tumors with echography. III. Diagnosis of intraocular tumors. Curr Concepts Ophthalmol 1974;4:280-96.  Back to cited text no. 1
    
2.
Aironi VD, Gandage SG. Pictorial essay: B-scan ultrasonography in ocular abnormalities. Indian J Radiol Imaging 2009;19:109-15.  Back to cited text no. 2
[PUBMED]  Medknow Journal  
3.
Fuller DG, Snyder WB, Hutton WL, Vaiser A. Ultrasonographic features of choroidal malignant melanomas. Arch Ophthalmol 1979;97:1465-72.  Back to cited text no. 3
[PUBMED]    
4.
Coleman DJ, Abramson DH, Jack RL, Franzen LA. Ultrasonic diagnosis of tumors of the choroid. Arch Ophthalmol 1974;91:344-54.  Back to cited text no. 4
[PUBMED]    
5.
Aironi VD, Chougule SR, Singh J. Choroidal melanoma: B-scan spectrum. Indian J Radiol Imaging 2007;17:8-10.  Back to cited text no. 5
  Medknow Journal  
6.
Liu CC, Kou HK, Tsai MH, Su CC, Kao ML, Chen YJ, et al. Choroidal masses: A fourteen year analysis. Chang Gung Med J 2001;24:502-11.  Back to cited text no. 6
    
7.
Green RL, Byrne SF. Diagnostic Ophthalmic Ultrasound. In: Hilton DR, Herbert GS, editors. Retina: Ryan SJ. 4 th ed. Elsevier Mosby Publishers; Philadelphia; 2006. p. 265-350.  Back to cited text no. 7
    
8.
Shields JA, Mashavekhi A, Ra S, Shields CL. Pseudomelanomas of the posterior uveal tract: The 2006 Taylor R. Smith Lecture. Retina 2005;25:767-71.  Back to cited text no. 8
    
9.
Shields CL, Shields JA. Choroidal Haemangioma. Semin Ophthalmol 1993;8:257-64.  Back to cited text no. 9
    
10.
Ossoing KC0. Preoperative differential diagnosis of tumors with echography. I. Physical principles and morphology, background of tissue echograms. Curr Concepts Ophthalmol 1974;4:280-96.  Back to cited text no. 10
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]


This article has been cited by
1 Clinics of Ocular Tuberculosis
Vishali Gupta,Samir S. Shoughy,Sarakshi Mahajan,Moncef Khairallah,James T. Rosenbaum,Andre Curi,Khalid F. Tabbara
Ocular Immunology & Inflammation. 2015; 23(1): 14
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Abstract
Materials and Me...
Results
Discussion
Conclusion
References
Article Figures
Article Tables

 Article Access Statistics
    Viewed1561    
    Printed26    
    Emailed3    
    PDF Downloaded222    
    Comments [Add]    
    Cited by others 1    

Recommend this journal