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Year : 2014  |  Volume : 62  |  Issue : 5  |  Page : 615-618

Influence of disc area on retinal nerve fiber layer thickness measurement by spectral domain optical coherence tomography

1 Department of Glaucoma, Vasan Eye Care, 8-1-5/7, Janak Plaza, Opp Clock Tower, SD Road, Secunderabad, Andhra Pradesh, India
2 Department of Biostatistics, National Institute Of Nutrition, Hyderabad, India
3 Pushpagiri Eye Institute, Secunderabad, Andhra Pradesh, India

Correspondence Address:
Tarannum Mansoori
Department of Glaucoma, Vasan Eye Care, 8-1-5/7, Janak Plaza, Opp. Clock Tower, SD Road, Secunderabad -500 003, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0301-4738.121134

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Background: To examine the effect of optic disc area on peripapillary RNFLT (retinal nerve fiber layer thickness) measurement at circle diameter of 3.4 mm around optic nerve head using spectral OCT/SLO (Optical coherence tomography/scanning laser ophthalmoscope). Materials and Methods : In this prospective, cross sectional study, one hundred and two eyes of 102 normal subjects underwent RNFLT and disc area measurement using spectral OCT/SLO. Based on disc area, subjects were divided into three groups i.e., <3 mm2 (32 eyes), 3-4 mm2 (36 eyes) and >4 mm2 (34 eyes). The effect of disc area on RNFLT parameters was analyzed using linear regression analysis. Results: The mean and quadrant RNFLT did not show significant correlation with disc area in subjects with disc area of <4 mm2, however in eyes with disc area >4 mm2, average RNFLT, superior and temporal quadrant RNFLT showed negative correlation with disc area, which was statistically significant (P = 0.004, P = 0.005 and P = 0.002, respectively) Conclusion: In healthy eyes of disc area <4 mm2, disc size does not appear to affect peripapillary RNFLT measurement by spectral OCT/SLO. Average, superior and temporal quadrant RNFLT measurements were inversely proportional to disc area in eyes with disc area >4 mm2. Hence, RNFLT measurement by OCT in eyes with optic disc area of >4 mm2 should be interpreted carefully.

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