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ORIGINAL ARTICLE
Year : 2014  |  Volume : 62  |  Issue : 6  |  Page : 699-701

Roles of elevated intravitreal IL-1β and IL-10 levels in proliferative diabetic retinopathy


Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China

Correspondence Address:
Dr. Hua Yan
Department of Ophthalmology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Tianjin-300052
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.136220

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Purpose: To determine the roles of interleukin (IL)-1β and IL-10 in the vitreous of proliferative diabetic retinopathy (PDR). Materials and Methods: Vitreous samples were obtained from 26 eyes of 26 patients with PDR and from eight eyes of eight cases without PDR. The IL-1β and IL-10 concentration in the vitreous was measured by using an enzyme-linked immunosorbent assay (ELISA). Results: Levels of IL-1β and IL-10 in vitreous were higher in PDR patients compared with control group. And there was significantly negative correlation between IL-1β and IL-10 in control group (r = −0.795; P = 0.032), whereas there was no significant correlation in PDR group (r = 0.176; P = 0.391). Conclusion: Levels of IL-1β and IL-10 were upregulated in vitreous of PDR patients, and these two cytokines play roles in regulating the development and progression of PDR.


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