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Year : 2014  |  Volume : 62  |  Issue : 9  |  Page : 974-975

Unusual lymphoma of lacrimal gland

Departments of Ophthalmology, Histopathology and Radiodiagnosis Post Graduate Institute of Medical Education and Research Chandigarh, India

Date of Web Publication4-Nov-2014

Correspondence Address:
Pankaj Gupta
Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0301-4738.143971

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How to cite this article:
Gupta P, Gupta K, Gupta V. Unusual lymphoma of lacrimal gland . Indian J Ophthalmol 2014;62:974-5

How to cite this URL:
Gupta P, Gupta K, Gupta V. Unusual lymphoma of lacrimal gland . Indian J Ophthalmol [serial online] 2014 [cited 2020 Jul 13];62:974-5. Available from: http://www.ijo.in/text.asp?2014/62/9/974/143971

Dear Sir,

Orbit is involved in upto 10% of all extranodal lymphomas. Lacrimal gland is the commonest orbital structure involved in orbital lymphomas. [1] We present a case of patient who presented with unusual features of lymphoma involving lacrimal gland. A 50-year-old female presented with painless gradually progressive mass in superotemporal orbit for last 6 months [Figure 1]a. There were no visual or systemic complaints. CT scan revealed well-localized homogenous hyperdense superotemporal orbital mass with bony fossa formation [Figure 1]b and globe indentation. Differential diagnoses of benign orbital mass including lacrimal gland pleomorphic adenoma, fibrous histiocytoma, schwannoma and neurofibroma were considered. The patient underwent orbitotomy with mass excision. The orbital mass measured 25 × 20 × 19 mm [Figure 1]c and had smooth outer surface. The histopathology of mass revealed diffuse sheets of atypical lymphoid cells present discretely, with small round to oval hyperchromatic nuclei and inconspicuous nucleoli [Figure 2]a and b. Occasional mitotic figures were seen. These cells were infiltrating the lacrimal gland substance [Figure 2]c. The cells were positive with CD20 and negative with CD3 [Figure 2]d and e. The final diagnosis of low grade B cell lymphoma involving lacrimal gland was made. The patient thereafter received systemic chemotherapy and orbital radiotherapy. Lymphoma of lacrimal gland usually presents radiologically with characteristic soft tissue deposits that are diffuse and tend to mould to the lacrimal gland and surrounding structures. [2] There are no bony changes or globe indentation. [2] The present patient presented with radiological features of solid orbital mass that have not been described in context of lacrimal gland lymphoma previously.
Figure 1: (a) Clinical photograph of the patient showing swelling in left upper eyelid region. (b) CT scan orbits showing superotemporal homogenous orbital mass with globe indentation and bony fossa formation. (c) Excised orbital mass

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Figure 2: (a) Diffused sheets of atypical lymphoid cells present discretely (H and E, ×100). (b) Small, round to oval cells with hyperchromatic nuclei and inconspicuous nucleoli (H and E, ×400). (c) Lymphomatous deposit infi ltrating and destroying the lacrimal gland (H and E, ×40) (d) Tumor cells immunopositive with CD20 (anti-CD20, ×100). (e) Tumor cells negative with CD3 (anti-CD3, ×100)

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  References Top

Rey-Porca C, Pérez-Encinas M, González F. Arch Soc Esp Oftalmol 2008;83:95-103.  Back to cited text no. 1
Mafee MF. Eye and orbit. In: Som PM, Curtin HD, editors. Head and Neck Imaging. 3 rd ed. St Louis: Mosby-Yearbook; 1996. p. 1009.  Back to cited text no. 2


  [Figure 1], [Figure 2]


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