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LETTER TO THE EDITOR
Year : 2015  |  Volume : 63  |  Issue : 1  |  Page : 82

Vitamin D supplementation in antiphospholipid syndrome patients


Neuro-ophthalmology Clinic, Glaucoma Service, AG Eye Hospital, Puthur, Trichy, Tamil Nadu, India

Date of Web Publication16-Feb-2015

Correspondence Address:
N Venugopal
No. 19, Mathuram Apartments, Officer's Colony (Behind YMCA), Puthur, Trichy - 620 017, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.151497

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How to cite this article:
Venugopal N. Vitamin D supplementation in antiphospholipid syndrome patients. Indian J Ophthalmol 2015;63:82

How to cite this URL:
Venugopal N. Vitamin D supplementation in antiphospholipid syndrome patients. Indian J Ophthalmol [serial online] 2015 [cited 2019 Oct 14];63:82. Available from: http://www.ijo.in/text.asp?2015/63/1/82/151497

Sir,

Tugcu et al. [1] in their article titled "nonarteritic anterior ischemic optic neuropathy as the presenting manifestation of primary antiphospholipid syndrome (APS)" have stressed the importance of considering APS in the differential diagnosis of ischemic optic neuropathy, particularly when the etiology is uncertain. We appreciate author's effort and research work. Vitamine D deficiency [2] is common among APS patients and is associated with clinically defined thrombotic events. Hypovitaminosis D [3] probably may have a complex origin in APS and may be part of the mosaic of factors that contribute to autoimmunity, rather than a consequence of chronic disease and treatment. To conclude vitamine D deficiency (<10-20 ng/ml) and insufficiency (<30 ng/ml) should be corrected in all antiphospholipid antibody positive (aPL) patients [4] based on general population guidelines. The prognostic role of vitamine D deficiency and therapeutic value of supplementation (including the dosage and definition of treatment goals) in aPL positive patients should be clarified by prospective studies.

 
  References Top

1.
Tugcu B, Acar N, Coskun CT, Celik S, Yigit FU. Nonarteritic anterior ischemic optic neuropathy as the presenting manifestation of primary antiphospholipid syndrome. Indian J Ophthalmol 2014;62:642-4.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Agmon-Levin N, Blank M, Zandman-Goddard G, Orbach H, Meroni PL, Tincani A, et al. Vitamin D: An instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression. Ann Rheum Dis 2011;70:145-50.  Back to cited text no. 2
    
3.
Andreoli L, Piantoni S, Dall'Ara F, Allegri F, Meroni PL, Tincani A. Vitamin D and antiphospholipid syndrome. Lupus 2012;21:736-40.  Back to cited text no. 3
    
4.
Erkan D, Aguiar CL, Andrade D, Cohen H, Cuadrado MJ, Danowski A, et al. 14 th International Congress on Antiphospholipid Antibodies: Task force report on antiphospholipid syndrome treatment trends. Autoimmun Rev 2014;13:685-96.  Back to cited text no. 4
    




 

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