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ORIGINAL ARTICLE
Year : 2015  |  Volume : 63  |  Issue : 1  |  Page : 9-14

Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up


1 Department of Ophthalmology, S. M. Goretti Hospital, Via G. Reni, 04100 Latina, Italy
2 Department of Ophthalmology, A. Fiorini Hospital, Via Firenze, 04019 Terracina, Sapienza University of Rome, Rome, Italy
3 Department of Sense Organs UOC B, Policlinico Umberto I Hospital, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
4 Department of Ophthalmology, San Giovanni Evangelista Hospital, Via Parrozzani 3, 00019 Tivoli, Italy

Correspondence Address:
Carmela Carnevale
Via Benadir 12, 00199 Rome
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.151455

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Aims: The aim was to evaluate circulating levels of reactive oxygen species (ROS) and changes in central macular thickness (CMT) in patients with nonproliferative diabetic retinopathy (NPDR) after antioxidant supplementation. Materials and Methods: A total of 68 patients (68 eyes) with NPDR were enrolled. Patients were randomly divided into two groups: Treated with antioxidant supplement (Group A) and untreated control group (Group B). Each tablet, for oral administration, containing pycnogenol 50 mg, Vitamin E 30 mg and coenzyme Q10 20 mg. CMT and free oxygen radical test (FORT) were analyzed at baseline (T0), 3 (T1) and 6 (T2) months in both groups. Results: In Group A, FORT levels and CMT were significantly reduced over time (P < 0.001 for both). In Group B, FORT levels were increased (P < 0.001) and CMT did not vary significantly (P = 0.81) over 3 time points. Conclusions: This is the first study showing the reduction of ROS levels in patients with NPDR thanks to antioxidant therapy. Moreover, our findings have suggested also an influence on retinal thickness.


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