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Year : 2015  |  Volume : 63  |  Issue : 3  |  Page : 211-218

Experimental autoimmune uveitis and other animal models of uveitis: An update

1 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore
2 Singapore Eye Research Institute; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore; SRP Neuroscience and Behavioral Disorder, DUKE-NUS Graduate Medical School, Singapore
3 Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
4 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; Singapore Eye Research Institute, Singapore; Institute of Ophthalmology, University College London, London

Correspondence Address:
Dr. Rupesh Agrawal
Consultant National Heathcare Group Eye Institute, Tan Tock Seng Hospital, Singapore 308433

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0301-4738.156914

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Over the past several decades, animal models of autoimmune uveitis directed at eye-specific antigens (Ags) have been developed. These have allowed researchers to understand the basic mechanisms that lead to these diseases and also recently helped the researchers in translational research for therapeutic interventions. Experimental autoimmune uveitis (EAU) is an animal disease model of human endogenous uveitis and can be induced in susceptible animals by immunization with retinal Ags. Ever since the first description of EAU in mice in 1988, several animal models of uveitis has been described by researchers. Disease-specific model for cytomegalovirus retinitis and tubercular uveitis has evolved our understanding of these complex entities. Endotoxin induced uveitis is another useful model for anterior uveitis, which is not an autoimmune process and is triggered by injection of bacterial endotoxin (lipopolysaccharides) resulting in a rapid short lasting uveitis. The current article will give an insight into the various EAU animal models and their current implications in translational research. The article will also highlight the different grading systems for EAU in the animal model.

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