Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 377
  • Home
  • Print this page
  • Email this page
OPHTHALMIC PERSPECTIVE
Year : 2015  |  Volume : 63  |  Issue : 4  |  Page : 335-339

Mitomycin-C in dacryocystorhinostomy: From experimentation to implementation and the road ahead: A review


1 Department of Ophthalmic Plastic Surgery and Ocular Oncology, Advanced Eye Hospital and Institute, Navi Mumbai; Department of Ophthalmic Plastic Surgery and Ocular Oncology, Aditya Jyot Eye Hospital, Mumbai; Department of Ophthalmology, Lokmanya Tilak Municipal General Hospital and Medical College, Mumbai, India
2 Ophthalmic Plastic Surgery Services, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, Telangana, India

Correspondence Address:
Dr. Akshay Gopinathan Nair
Department of Ophthalmic Plastic Surgery and Ocular Oncology, Advanced Eye Hospital and Institute, 30 The Affaires, Sector 17, Sanpada, Navi Mumbai - 400 705, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.158082

Rights and Permissions

Dacryocystorhinostomy (DCR) is the procedure of choice in patients with epiphora due to primary acquired nasolacrimal duct obstruction. The evolution of surgical tools, fiber-optic endoscopes, effective anesthesia techniques, and the adjunct use of antimetabolites intraoperatively; namely mitomycin-C (MMC) have significantly contributed to the advancement of DCR surgery. MMC is a systemic chemotherapeutic agent derived from Streptomyces caespitosus that inhibits the synthesis of DNA, cellular RNA, and protein by inhibiting the synthesis of collagen by fibroblasts. Even the cellular changes in the human nasal mucosal fibroblasts induced by MMC at an ultrastructural level have been documented. There, however, seems to be a lack of consensus regarding MMC: The dosage, the route of delivery/application, the time of exposure and subsequently what role each of these variables plays in the final outcome of the surgery. In this review, an attempt is made to objectively examine all the evidence regarding the role of MMC in DCR. MMC appears to improve the success rate of DCR.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3033    
    Printed24    
    Emailed0    
    PDF Downloaded445    
    Comments [Add]    

Recommend this journal