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Year : 2015  |  Volume : 63  |  Issue : 5  |  Page : 378-383

En-face optical coherence tomography in the diagnosis and management of age-related macular degeneration and polypoidal choroidal vasculopathy

1 The Department of Ophthalmology, Hong Kong eye Hospital, Hong Kong, China
2 The Department of Ophthalmology, The University of Hong Kong, Hong Kong, China
3 The Department of Ophthalmology, LV Prasad Eye Institute, Hyderabad, Telangana, India
4 The Department of Ophthalmology, People's Hospital, Peking University, Beijing, China
5 The Department of Ophthalmology, Tokyo Women's Medical University, Tokyo, Japan
6 The Department of Ophthalmology, Caritas Medical Center, Hong Kong, China

Correspondence Address:
Dr. Ian Y Wong
Room 301, Level 3, Block B, Cyberport 4, Pokfulam, Hong Kong
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0301-4738.159860

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Optical coherence tomography (OCT) is a noninvasive imaging modality providing high-resolution images of the central retina that has completely transformed the field of ophthalmology. While traditional OCT has produced longitudinal cross-sectional images, advancements in data processing have led to the development of en-face OCT, which produces transverse images of retinal and choroidal layers at any specified depth. This offers additional benefit on top of longitudinal cross-sections because it provides an extensive overview of pathological structures in a single image. The aim of this review was to discuss the utility of en-face OCT in the diagnosis and management of age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). En-face imaging of the inner segment/outer segment junction of retinal photoreceptors has been shown to be a useful indicator of visual acuity and a predictor of the extent of progression of geographic atrophy. En-face OCT has also enabled high-resolution analysis and quantification of pathological structures such as reticular pseudodrusen (RPD) and choroidal neovascularization, which have the potential to become useful markers for disease monitoring. En-face Doppler OCT enables subtle changes in the choroidal vasculature to be detected in eyes with RPD and AMD, which has significantly advanced our understanding of their pathogenesis. En-face Doppler OCT has also been shown to be useful for detecting the polypoid lesions and branching vascular networks diagnostic of PCV. It may therefore serve as a noninvasive alternative to fluorescein and indocyanine green angiography for the diagnosis of PCV and other forms of the exudative macular disease.

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