|LETTER TO THE EDITOR
|Year : 2016 | Volume
| Issue : 2 | Page : 171-172
Handheld spectral domain optical coherence tomography seems to be a must-have device for future treatment methods of hereditary maculopathies
Oktay Diner1, Yakup Aksoy2, Abdullah Kaya3, Mehmet Koray SevinÁ4
1 Department of Ophthalmology, Erzurum Military Hospital, Erzurum, Turkey
2 Department of Ophthalmology, Girne Military Hospital, Girne, Cyprus
3 Department of Ophthalmology, Anıttepe Military Dispensary, Ankara, Turkey
4 Department of Ophthalmology, Beytepe Military Hospital, Ankara, Turkey
|Date of Web Publication||5-Apr-2016|
Dr. Abdullah Kaya
Department of Ophthalmology, Anıttepe Military Dispansery, Ankara
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Diner O, Aksoy Y, Kaya A, SevinÁ MK. Handheld spectral domain optical coherence tomography seems to be a must-have device for future treatment methods of hereditary maculopathies. Indian J Ophthalmol 2016;64:171-2
|How to cite this URL:|
Diner O, Aksoy Y, Kaya A, SevinÁ MK. Handheld spectral domain optical coherence tomography seems to be a must-have device for future treatment methods of hereditary maculopathies. Indian J Ophthalmol [serial online] 2016 [cited 2019 Oct 18];64:171-2. Available from: http://www.ijo.in/text.asp?2016/64/2/171/179730
We have read with great interest the article entitled “The use of handheld spectral domain optical coherence tomography in pediatric ophthalmology practice: Our experience of 975 infants and children.” We thank the author for presenting their experiences with handheld spectral domain optic coherence tomography (SD-OCT). This study has showed us that SD-OCT is a revolutionary investigation for diagnosis in pediatric population. Especially, early detection of maculopathies by this device is very exciting. Hereditary maculopathies often do not give any clinical finding in the examination of children. If there could be a development in treatment of these diseases, it will be crucial to detect maculopathy early to prevent permanent photoreceptor and/or retina pigment epithelium (RPE) injuries. Hereditary maculopathies are generally genetic disorders and characterized by progressive photoreceptor and/or RPE degeneration. There are promising studies about the treatment of these diseases by gene therapy. In a recent study, retinitis pigmentosa GTPase regulator gene augmentation by adeno-associated virus 2/5 vector has been shown to prevent photoreceptor degeneration. However, it investigated that this therapy could only be useful when applied before degeneration of photoreceptors. Hence, if it could be possible to cure maculopathies by genetic methods, early diagnose will be very important to survive photoreceptors. Another treatment area for hereditary maculopathies is cell replacement therapy. It could be possible to transplant stem-cell-derived photoreceptor precursors to the diseased eye. There is increasing publication about this therapy. If there will be possible to apply such a therapy, early diagnose, and treatment of disease will provide better outcomes and prevent amblyopia. Thus, handheld SD-OCT seems to be a must-have device for future revolutionary treatment methods in this area of ophthalmology.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Mallipatna A, Vinekar A, Jayadev C, Dabir S, Sivakumar M, Krishnan N, et al.
The use of handheld spectral domain optical coherence tomography in pediatric ophthalmology practice: Our experience of 975 infants and children. Indian J Ophthalmol 2015;63:586-93.
Megaw RD, Soares DC, Wright AF. RPGR: Its role in photoreceptor physiology, human disease, and future therapies. Exp Eye Res 2015;138:32-41.
Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, et al.
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proc Natl Acad Sci U S A 2012;109:2132-7.
MacLaren RE, Pearson RA, MacNeil A, Douglas RH, Salt TE, Akimoto M, et al.
Retinal repair by transplantation of photoreceptor precursors. Nature 2006;444:203-7.