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REVIEW ARTICLE
Year : 2016  |  Volume : 64  |  Issue : 9  |  Page : 628-634

Roles of interleukin-17 in uveitis


1 Western Lisbon Hospital Center, Egas Moniz Hospital, Lisbon, Portugal
2 Luis Miguel Borrego, CUF Descobertas Hospital, Lisbon, Portugal
3 Coimbra Hospital and Universitary Center, Coimbra, Portugal

Correspondence Address:
Dr. Marta Catarina Esteves Guedes
Western Lisbon Hospital Center, Egas Moniz Hospital, Lisbon
Portugal
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.194339

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Th17 cells, a CD4+ T-cell subset, produce interleukin (IL)-17, a pro-inflammatory cytokine that has been shown to be involved in several forms of infectious and noninfectious uveitis. Here, we explore the roles of this IL in uveitic disorders as well as in experimental autoimmune uveitis, the possible pathogenic implications of several cytokines associated with IL-17 and analyze the current outcomes and goals for drugs aiming for the IL-17 pathway.


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