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   Table of Contents      
LETTER TO THE EDITOR
Year : 2017  |  Volume : 65  |  Issue : 11  |  Page : 1265-1266

Conjunctival leiomyosarcoma: A case report and review of literature


Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Web Publication13-Nov-2017

Correspondence Address:
Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, P. O. Box. 55302, Baghdad Post Office, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_477_17

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How to cite this article:
Al-Mendalawi MD. Conjunctival leiomyosarcoma: A case report and review of literature. Indian J Ophthalmol 2017;65:1265-6

How to cite this URL:
Al-Mendalawi MD. Conjunctival leiomyosarcoma: A case report and review of literature. Indian J Ophthalmol [serial online] 2017 [cited 2019 Dec 13];65:1265-6. Available from: http://www.ijo.in/text.asp?2017/65/11/1265/218059

Sir,

I read with interest the case report on the conjunctival leiomyosarcoma reported by Montes et al.[1] Leiomyosarcoma is one of the most common and serious smooth muscle tumors (SMTs) in the body. Patients infected with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) are susceptible to various types of tumors, including SMTs. There is a close association between Epstein–Barr virus (EBV) infection and SMTs evolution in patients infected with HIV/AIDS.[2] Moreover, SMTs in these patients typically arise in multiple and very unusual sites that are not often observed in SMTs among immunocompetent individuals.[3] To my knowledge, HIV infection is an important health problem in Spain. Although no recent data are yet present on the exact seroprevalence HIV infection in Spain, the available data pointed out that the overall HIV seroprevalence among persons seeking HIV testing was reported to be substantial (2.5%).[4] I presume that HIV infection should be critically considered in the studied patient with leiomyosarcoma affecting the unusual site. Hence, the diagnostic algorithm of immunohistochemical stains and in situ hybridization for EBV-encoded ribonucleic acid in the surgically resected tumor tissues as well as blood CD4 count and viral overload estimations for HIV infection was solicited. If that diagnostic algorithm was contemplated and it revealed underling EBV-HIV infection, the case in question could truly extend the spectrum of ophthalmic leiomyosarcoma associated with EBV-HIV infection rarely reported in the literature so far.[5]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Montes TL, Agra MV, Alonso MS, Lorenzo AO. Conjunctival leiomyosarcoma: A case report and review of literature. Indian J Ophthalmol 2017;65:406-8.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
McClain KL, Leach CT, Jenson HB, Joshi VV, Pollock BH, Parmley RT, et al. Association of Epstein-Barr virus with leiomyosarcomas in young people with AIDS. N Engl J Med 1995;332:12-8.  Back to cited text no. 2
[PUBMED]    
3.
Suankratay C, Shuangshoti S, Mutirangura A, Prasanthai V, Lerdlum S, Shuangshoti S, et al. Epstein-Barr virus infection-associated smooth-muscle tumors in patients with AIDS. Clin Infect Dis 2005;40:1521-8.  Back to cited text no. 3
[PUBMED]    
4.
Diez M, Bleda MJ, Varela Jr., Ordonana J, Azpiri MA, Vall M, et al. Trends in HIV testing, prevalence among first-time testers, and incidence in most-at-risk populations in Spain: The EPI-VIH study, 2000 to 2009. Euro Surveill 2014;19:20971.  Back to cited text no. 4
    
5.
Tulvatana W, Pancharoen C, Mekmullica J, Thisyakorn U, Tinnungwattana U, Keetacheeva K, et al. Epstein-Barr virus-associated leiomyosarcoma of the iris in a child infected with human immunodeficiency virus. Arch Ophthalmol 2003;121:1478-81.  Back to cited text no. 5
[PUBMED]    




 

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